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Études sur Urolithine A

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662 études au total·Dernière mise à jour : June 22, 2026Ouvrir sur PubMed

Muscle strength · 21

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  1. 01
    Age-related sarcopenia and the gut microbiome: mechanistic insights into the gut-muscle axis and potential microbiome based therapeutic interventions
    Allen SL, Breen L, Lord JM et al. · Ageing Res Rev · 2026
  2. 02
    Effects of Urolithin A on Mitochondrial Homeostasis Disruption by LPS in C2C12 Myotubes
    Tapia-Curimil G, Valero-Breton M, Deldicque L et al. · Cell Physiol Biochem · 2026
  3. 03
    Regulation of skeletal muscle development and metabolism in broiler chickens by Urolithin A through threonine kinase 1 pathway activation
    Wu L, Peng L, Zhao X · Poult Sci · 2026
  4. 04
    Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners
    Whitfield J, McKay AKA, Tee N et al. · Sports Med · 2025RCT
  5. 05
    Recent advances in exercise immunometabolism: Immune cell bioenergetics, muscle-immune cell interactions, and potential dietary adjuvants
    Islam H · Curr Opin Clin Nutr Metab Care · 2025
  6. 06
    Sepsis Induces Long-Term Muscle and Mitochondrial Dysfunction due to Autophagy Disruption Amenable by Urolithin A
    Pierre A, Favory R, Brassart B et al. · J Cachexia Sarcopenia Muscle · 2025
  7. 07
    Myogenic nano-adjuvant for orthopedic-related sarcopenia via mitochondrial homeostasis modulation in macrophage-myosatellite metabolic crosstalk
    Zhang X, Zhang P, Zhu Y et al. · J Nanobiotechnology · 2025
  8. 08
    Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy
    Mikhail AI, Ng SY, Xhuti D et al. · J Cachexia Sarcopenia Muscle · 2025
  9. 09
    A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing
    Park SH, Choi PG, Kim HS et al. · J Cachexia Sarcopenia Muscle · 2025
  10. 10
    Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study
    Zhao H, Zhu H, Yun H et al. · J Int Soc Sports Nutr · 2024RCT
  11. 11
    Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing
    Broome SC, Whitfield J, Karagounis LG et al. · Sports Med · 2024
  12. 12
    Mitophagy Activation by Urolithin A to Target Muscle Aging
    Faitg J, D'Amico D, Rinsch C et al. · Calcif Tissue Int · 2024
  13. 13
    Skeletal muscles and gut microbiota-derived metabolites: novel modulators of adipocyte thermogenesis
    Tang Y, Wang YD, Wang YY et al. · Front Endocrinol (Lausanne) · 2023
  14. 14
    Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults
    Singh A, D'Amico D, Andreux PA et al. · Cell Rep Med · 2022RCT
  15. 15
    Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial
    Liu S, D'Amico D, Shankland E et al. · JAMA Netw Open · 2022RCT
  16. 16
    Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy
    Luan P, D'Amico D, Andreux PA et al. · Sci Transl Med · 2021
  17. 17
    Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD(+) and SIRT1
    Ghosh N, Das A, Biswas N et al. · Sci Rep · 2020
  18. 18
    Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet-Induced Insulin Resistance in Mice
    Yang J, Guo Y, Henning SM et al. · Mol Nutr Food Res · 2020
  19. 19
    Consumption of Watermelon Juice Enriched in l-Citrulline and Pomegranate Ellagitannins Enhanced Metabolism during Physical Exercise
    Martínez-Sánchez A, Alacid F, Rubio-Arias JA et al. · J Agric Food Chem · 2017RCT
  20. 20
    Pomegranate extract prevents skeletal muscle of mice against wasting induced by acute TNF-α injection
    Rodriguez J, Caille O, Ferreira D et al. · Mol Nutr Food Res · 2017
  21. 21
    Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
    Ryu D, Mouchiroud L, Andreux PA et al. · Nat Med · 2016

Energy & endurance · 18

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  1. 01
    Urolithin A: a multi-target therapeutic candidate derived from the gut microbiota for obesity and metabolic dysfunction
    Liu C, Sun M, Zhao Z et al. · Front Endocrinol (Lausanne) · 2026
  2. 02
    Targeting autophagy via mitochondrial uncoupling: Discovery of novel serratin derivative as a potential therapeutic for Parkinson's disease
    Rudenko AY, Guseva EА, Ozhiganov RM et al. · Biochimie · 2026
  3. 03
    Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners
    Whitfield J, McKay AKA, Tee N et al. · Sports Med · 2025RCT
  4. 04
    Recent advances in exercise immunometabolism: Immune cell bioenergetics, muscle-immune cell interactions, and potential dietary adjuvants
    Islam H · Curr Opin Clin Nutr Metab Care · 2025
  5. 05
    Mitochondrial and microtubule defects in Exfoliation Glaucoma
    Venkatesan A, Ridilla M, Castro N et al. · Free Radic Biol Med · 2025
  6. 06
    Urolithin A attenuates Doxorubicin-induced cardiotoxicity by enhancing PINK1-regulated mitophagy via Ambra1
    Wang X, Ma C, Mi K et al. · Chem Biol Interact · 2025
  7. 07
    Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study
    Zhao H, Zhu H, Yun H et al. · J Int Soc Sports Nutr · 2024RCT
  8. 08
    Increased Glycolytic Activity Is Part of Impeded M1(LPS) Macrophage Polarization in the Presence of Urolithin A
    Bahiraii S, Braunböck-Müller B, Heiss EH · Planta Med · 2024
  9. 09
    Effects of Urolithin A on Mitochondrial Parameters in a Cellular Model of Early Alzheimer Disease
    Esselun C, Theyssen E, Eckert GP · Int J Mol Sci · 2021
  10. 10
    Urolithin A, a pomegranate metabolite, protects pancreatic β cells from apoptosis by activating autophagy
    Zhang Y, Zhang Y, Halemahebai G et al. · J Ethnopharmacol · 2021
  11. 11
    Sarcopenia in chronic liver disease: mechanisms and countermeasures
    Allen SL, Quinlan JI, Dhaliwal A et al. · Am J Physiol Gastrointest Liver Physiol · 2021
  12. 12
    Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat Model
    Żary-Sikorska E, Fotschki B, Jurgoński A et al. · Molecules · 2020
  13. 13
    Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice
    Xia B, Shi XC, Xie BC et al. · PLoS Biol · 2020
  14. 14
    Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells
    Norden E, Heiss EH · Carcinogenesis · 2019
  15. 15
    Addition of strawberries to the usual diet decreases resting chemiluminescence of fasting blood in healthy subjects-possible health-promoting effect of these fruits consumption
    Bialasiewicz P, Prymont-Przyminska A, Zwolinska A et al. · J Am Coll Nutr · 2014
  16. 16
    Urolithins display both antioxidant and pro-oxidant activities depending on assay system and conditions
    Kallio T, Kallio J, Jaakkola M et al. · J Agric Food Chem · 2013
  17. 17
    In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells
    Qiu Z, Zhou B, Jin L et al. · Food Chem Toxicol · 2013
  18. 18
    Strawberry consumption is associated with increased antioxidant capacity in serum
    Henning SM, Seeram NP, Zhang Y et al. · J Med Food · 2010

Longevity & aging · 52

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  1. 01
    Age-related sarcopenia and the gut microbiome: mechanistic insights into the gut-muscle axis and potential microbiome based therapeutic interventions
    Allen SL, Breen L, Lord JM et al. · Ageing Res Rev · 2026
  2. 02
    Urolithin A: A Novel Postbiotic for inflammation, aging, and cancer: A Journey from Dietary ellagitannins to clinical use
    Thakur S, Chaitanya MVNL, Singh SK et al. · Mol Biol Rep · 2026
  3. 03
    Dietary Polyphenols in Aging: A Systems-Level Perspective on Mitochondrial Quality Control and Microbiome Interactions
    Yılmaz A, Park HJ, Ahn EM et al. · Int J Mol Sci · 2026
  4. 04
    Mitochondria at the heart of aging: structure, function, and failure
    Marei HE · J Transl Med · 2026
  5. 05
    SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways
    Weiss B, Miranda DR, Arrazati D et al. · Drug Des Devel Ther · 2026
  6. 06
    Urolithin A Attenuates Aging-Induced Liver Injury by Inhibiting Nur77 Ubiquitination and Degradation
    Xiao J, Qu L, Qin X et al. · J Agric Food Chem · 2026
  7. 07
    Dietary urolithin a improves hepatic antioxidant function and laying performance in aging hens via Nrf2 signaling pathway activation
    Wu L, Zhang Y, Peng L et al. · Poult Sci · 2026
  8. 08
    SIRT3 attenuates AGEs-induced senescence in human granulosa cells through enhancing mitophagy
    Li S, Tang M, Zhu S et al. · Cell Biol Toxicol · 2026
  9. 09
    Distinct roles of urolithin A and spermidine in mitophagy and autophagy: implications for dietary supplementation
    Borsky P, Holmannova D, Soukup O et al. · Nutr Res Rev · 2025
  10. 10
    Urolithin Α modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing
    Roussos A, Kitopoulou K, Borbolis F et al. · Autophagy · 2025
  11. 11
    Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
    Denk D, Singh A, Kasler HG et al. · Nat Aging · 2025RCT
  12. 12
    Mitigating Pro-Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy
    Barkovskaya A, Brauning A, Thambala A et al. · Aging Cell · 2025
  13. 13
    Urolithin A Alleviates Doxorubicin-Induced Senescence in Mesenchymal Stem Cells
    Kalinin A, Zubkova E, Menshikov M et al. · Int J Mol Sci · 2025
  14. 14
    Age-Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function
    Sonar SA, Bhat R, Thompson HL et al. · Aging Cell · 2025
  15. 15
    Astrocytic HSP60 Deletion Induced Astrocyte Senescence and Inhibited Neuroregeneration via Modulating the S1P/Truncated-BDNF Pathway
    Zhu W, Cheng Y, Lang Z et al. · J Neurosci Res · 2025
  16. 16
    Promotion of Healthy Aging Through the Nexus of Gut Microbiota and Dietary Phytochemicals
    Beaver LM, Jamieson PE, Wong CP et al. · Adv Nutr · 2025
  17. 17
    A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing
    Park SH, Choi PG, Kim HS et al. · J Cachexia Sarcopenia Muscle · 2025
  18. 18
    Caenorhabditis elegans as a Screening Platform for Anti-aging Compounds
    Mytilinaiou E, Kitopoulou K, Palikaras K · Methods Mol Biol · 2025
  19. 19
    Urolithin A Modulates PER2 Degradation via SIRT1 and Enhances the Amplitude of Circadian Clocks in Human Senescent Cells
    Kuatov R, Takano J, Arie H et al. · Nutrients · 2024
  20. 20
    Environmentally relevant concentrations of perfluorobutane sulfonate impair locomotion behaviors and healthspan by downregulating mitophagy in C. elegans
    Shang Y, Chen K, Ni H et al. · J Hazard Mater · 2024
  21. 21
    Urolithin A prevents age-related hearing loss in C57BL/6J mice likely by inducing mitophagy
    Cho SI, Jo ER, Jang HS · Exp Gerontol · 2024
  22. 22
    Activation of the Gut-Brain Interaction by Urolithin A and Its Molecular Basis
    Kubota D, Sato M, Udono M et al. · Nutrients · 2024
  23. 23
    Age-related sarcopenia and altered gut microbiota: A systematic review
    Wang M, Ren F, Zhou Y et al. · Microb Pathog · 2024SR
  24. 24
    Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim
    Sandalova E, Li H, Guan L et al. · Geroscience · 2024
  25. 25
    Amyloid β accelerates age-related proteome-wide protein insolubility
    Anderton E, Chamoli M, Bhaumik D et al. · Geroscience · 2024

Immune system · 44

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  1. 01
    Urolithin A blocks colorectal cancer progression by AKT1 inhibition-driven immune activation
    Sun Z, Li J, Chen H et al. · Sci Rep · 2026
  2. 02
    Urolithin A Attenuates Aging-Induced Liver Injury by Inhibiting Nur77 Ubiquitination and Degradation
    Xiao J, Qu L, Qin X et al. · J Agric Food Chem · 2026
  3. 03
    Mitochondrial dysfunction drives natural killer cell dysfunction in systemic lupus erythematosus
    Fluder N, Humbel M, Recazens E et al. · JCI Insight · 2026
  4. 04
    Urolithin A Attenuates Sleep Deprivation-Induced Neutrophilic Inflammation by Suppression of the ROS-H3K18la Feedback Loop
    Zhou R, Li K, Zhang H et al. · J Agric Food Chem · 2026
  5. 05
    Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
    Denk D, Singh A, Kasler HG et al. · Nat Aging · 2025RCT
  6. 06
    Recent advances in exercise immunometabolism: Immune cell bioenergetics, muscle-immune cell interactions, and potential dietary adjuvants
    Islam H · Curr Opin Clin Nutr Metab Care · 2025
  7. 07
    Urolithin-A supplementation alleviates sepsis-induced acute lung injury by reducing mitochondrial dysfunction and modulating macrophage polarization
    Mohsin M, Zaki A, Tabassum G et al. · Mitochondrion · 2025
  8. 08
    Synthesis, characterization, and anti-inflammatory potential of serotonin- and dopamine-conjugates of urolithin A
    Korczak M, Redl M, Roszkowski P et al. · Biomed Pharmacother · 2025
  9. 09
    Age-Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function
    Sonar SA, Bhat R, Thompson HL et al. · Aging Cell · 2025
  10. 10
    Myogenic nano-adjuvant for orthopedic-related sarcopenia via mitochondrial homeostasis modulation in macrophage-myosatellite metabolic crosstalk
    Zhang X, Zhang P, Zhu Y et al. · J Nanobiotechnology · 2025
  11. 11
    Effect of urolithin A on intracellular survival of Mycobacterium tuberculosis by regulating AKT-FOXO1-mediated autophagy
    Bi J, Song L, Guo Q et al. · mSphere · 2025
  12. 12
    Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity
    Akhtar A, Shakir M, Ansari MS et al. · Cell Rep Med · 2025
  13. 13
    Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages
    Zheng B, Wang Y, Zhou B et al. · J Adv Res · 2025
  14. 14
    [Effect of urolithin A on production of interleukins 6 and 10 by immune cells from patients with MS and healthy donors]
    Kukushkina AD, Rogovsky VS, Boyko AN · Zh Nevrol Psikhiatr Im S S Korsakova · 2025
  15. 15
    Urolithin A suppresses NLRP3 inflammasome activation by inhibiting the generation of reactive oxygen species and prevents monosodium urate crystal-induced peritonitis
    Komatsu W, Kishi H, Uchiyama K et al. · Biosci Biotechnol Biochem · 2024
  16. 16
    Increased Glycolytic Activity Is Part of Impeded M1(LPS) Macrophage Polarization in the Presence of Urolithin A
    Bahiraii S, Braunböck-Müller B, Heiss EH · Planta Med · 2024
  17. 17
    Urolithin-A Promotes CD8+ T Cell-mediated Cancer Immunosurveillance via FOXO1 Activation
    Ginefra P, Hope HC, Chiang YH et al. · Cancer Res Commun · 2024
  18. 18
    Urolithin A Hijacks ERK1/2-ULK1 Cascade to Improve CD8(+) T Cell Fitness for Antitumor Immunity
    Ma S, Wu Q, Wu W et al. · Adv Sci (Weinh) · 2024
  19. 19
    The cGAS-STING signaling pathway is modulated by urolithin A
    Madsen HB, Park JH, Chu X et al. · Mech Ageing Dev · 2024
  20. 20
    Inhibitory Effects of Urolithins, Bioactive Gut Metabolites from Natural Polyphenols, against Glioblastoma Progression
    Shen CK, Huang BR, Charoensaensuk V et al. · Nutrients · 2023
  21. 21
    Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy
    Chu C, Wang X, Yang C et al. · Redox Biol · 2023
  22. 22
    PINK1-mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages
    Jiang K, Li J, Jiang L et al. · Oral Dis · 2023
  23. 23
    Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
    Han D, Wu Y, Lu D et al. · Cell Death Dis · 2023
  24. 24
    Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems
    Girotra M, Chiang YH, Charmoy M et al. · Nat Aging · 2023
  25. 25
    Deficiency of Pink1 promotes the differentiation of Th1 cells
    Mei X, Lei Y, Ouyang L et al. · Mol Immunol · 2023