Base de preuves

Études sur Bêta-hydroxybutyrate (BHB / cétones exogènes)

Chargées automatiquement depuis PubMed — regroupées par résultat. Chaque entrée renvoie à la source d'origine.

13,607 études au total·Dernière mise à jour : June 12, 2026Ouvrir sur PubMed

Energy & endurance · 1,813

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  1. 01
    FKBP4-mediated reprogramming of H3K4bhb at energy metabolism ameliorates ischemic acute kidney injury
    Zhao Z, Zhou J, Chen S et al. · Int J Biol Macromol · 2026
  2. 02
    Hepatic ketogenesis is not required for exercise training to mitigate diet-induced liver steatosis in male mice
    Vang CM, Ortega AF, Pfeiffer RE et al. · Function (Oxf) · 2026
  3. 03
    Exercise Metabolic Flexibility in Type 2 Diabetes Treated With Empagliflozin: An Exploratory Analysis of the Randomised Trial EMPA-HEART
    Nesti L, Santoni L, Baldi S et al. · Diabetes Obes Metab · 2026RCT
  4. 04
    Ketone Ester Attenuates Thoracic Aortic Aneurysm and Dissection by Suppressing Ferroptosis
    Shrestha S, Wu Y, Li J et al. · Cells · 2026
  5. 05
    Combined high-fat, high-sucrose diet and streptozotocin treatment induces cardiometabolic heart failure with preserved ejection fraction in mice
    Heinen A, Spychala A, Ballmann L et al. · Am J Physiol Heart Circ Physiol · 2026
  6. 06
    Genetic Parameter Estimation for Plasma Biomarkers Associated With Energy Reserves During Critical Physiological Stages in Sheep
    Nyamiel A, Legarra A, Marcon D et al. · J Anim Breed Genet · 2026
  7. 07
    Nutrient-driven histone acetylation underlies energy storage and mobilization
    Chen L, Zhu L, Xiao H et al. · Mol Metab · 2026
  8. 08
    β-Hydroxybutyrate impairs the functional response of bovine neutrophils to mammary pathogenic Staphylococcus aureus and a TLR2/1 agonist by limiting glucose metabolism
    Quiroga J, Burgos RA, Henríquez C et al. · J Dairy Sci · 2026
  9. 09
    Chemical Proteomics Identifies Ketogenesis-Mediated Cysteine Modifications Regulating Redox Function
    Zhou YF, Zhang L, Niu ZL et al. · Angew Chem Int Ed Engl · 2026
  10. 10
    β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer
    Liu S, Guruprasad P, Ramasubramanian R et al. · Cell · 2026
  11. 11
    Empagliflozin Attenuates Global Cerebral Ischemic Injury After Cardiac Arrest Through Enhancing Ketone Body Oxidative Metabolism in Rats
    Wang P, Liang L, Tan Y et al. · J Am Heart Assoc · 2026
  12. 12
    Stimulating anaerobic degradation of biodegradable plastics by promoting direct interspecies electron transfer via conductive materials
    Akram J, Jin Y, Song C et al. · Bioresour Technol · 2026
  13. 13
    Aging and metabolism in HFpEF: Pathophysiology and therapeutic implications
    Ye M, Feng S, Xu Z et al. · Metabolism · 2026
  14. 14
    Effect of Oral Ketone Body Intake on Human CD8(+) T-Cell Immunometabolism
    Effinger D, Hirschberger S, Arntjen T et al. · Nutrients · 2026
  15. 15
    Impact of the Combination of Epigallocatechin Gallate and Ellagic Acid Supplemented with Ketone Bodies on Energetic Restoration of Mitochondrial Dysfunction and Metabolic Inefficiencies in Patients with Multiple Sclerosis: A Review
    de la Rubia Ortí JE, Roig-Soriano A, Carrera-Juliá S et al. · Int J Mol Sci · 2026
  16. 16
    Disparate Hepatic Mitochondrial and Inflammatory Effects of Ketone Supplements
    Morris TJ, Morris MD, Parker AJ et al. · Nutrients · 2026
  17. 17
    Epicardial adipose tissue produces L-3-hydroxybutyrate in advanced heart failure: direct analysis of fat metabolic remodeling
    Riecan M, Kasperova BJ, Vondrackova M et al. · Metabolism · 2026
  18. 18
    From ketogenic metabolism to targeted therapeutics: current advances in β-hydroxybutyrylation
    Hu F, Liang C, Zhang X et al. · Front Immunol · 2025
  19. 19
    β-Hydroxybutyrate-Induced Ferroptosis Contributes to Hepatic Oxidative Injury in Dairy Cows with Clinical Ketosis
    Mei S, Wang L, Ding Y et al. · J Agric Food Chem · 2026
  20. 20
    Alterations in blood metabolites as biomarkers of fatigue and recovery in thoroughbred horses performing repeated bouts of high-intensity exercise
    Lungu GM, Barshick MR, Shafron AJ et al. · J Anim Sci · 2026
  21. 21
    BDH1 Mediates Aerobic Exercise-Induced Improvement in Skeletal Muscle Metabolic Remodeling in Type 2 Diabetes Mellitus
    Wu M, Ma X, Dai W et al. · Biomolecules · 2026
  22. 22
    Metabolic responses to 48 h fasting and refeeding in adults with and without obesity
    Sandilands R, Neudorf H, Ursel S et al. · Appl Physiol Nutr Metab · 2026
  23. 23
    Gulls foraging in highly urbanized areas experience disruption in hormones and energetic metabolism
    Turquois C, Mazerolle MJ, Sauvé S et al. · Environ Int · 2026
  24. 24
    Ginsenoside Rd promotes cardiac regeneration through PPARG/HMGCS2-driven ketone body metabolic reprogramming in myocardial ischemia-reperfusion injury
    Zhang H, Lin A, Zhai C et al. · Phytomedicine · 2026
  25. 25
    Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction
    Yeh CY, Borgelt AL, Vogt BJ et al. · Aging Cell · 2026

Cognition · 82

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  1. 01
    Intermittent Fasting Attenuates Cognitive Decline in D-Galactose-Induced Aging Rats in Association with β-Hydroxybutyrate and PI3K/AKT/GSK-3β Signaling
    Lin X, Huang L, Ling X et al. · Neurochem Res · 2026
  2. 02
    Exogenous ketosis mitigates hypoxia-induced neural signaling alterations and cerebral oxygenation decline at rest in healthy males
    Vermaerke N, Vermeiren S, Tominec D et al. · J Appl Physiol (1985) · 2026RCT
  3. 03
    Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore adult hippocampal neurogenesis and cognitive function in high-fat diet induced obesity in mice
    Kwon H, Seo DS, Ahmad Y et al. · J Nutr Biochem · 2026
  4. 04
    HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease
    Yu H, Wang F, Yuan JQ et al. · Exp Mol Med · 2026
  5. 05
    The effect of exogenous ketone monoester supplementation on cerebral blood flow and functional brain characteristics in adults with subjective cognitive decline: study protocol for a randomized crossover trial
    Danielli E, Rourke AJ, Coombs GB et al. · Trials · 2026
  6. 06
    Hepatic HMGCS2-derived β-hydroxybutyrate attenuates hippocampal insulin resistance and neuroinflammation to promote MASLD-induced cognitive function
    Nie L, Sun J, Xu W et al. · Commun Biol · 2026
  7. 07
    Fasted-State Aerobic Exercise Enhances Cognition and Hippocampal BDNF Signaling in an Alzheimer's Disease Rat Model
    Kirkbir F, Atasoy T, Khodadadai D et al. · Neurochem Res · 2025
  8. 08
    Synbiotic intervention reverses alcohol drinking-induced cognitive deficits in adolescent male mice by modulating the microbiota-gut-brain axis
    Barrera-Conde M, Korchevaya E, Kossatz E et al. · Gut Microbes · 2025
  9. 09
    Ketone monoester alleviates cognitive impairment in a transgenic mouse model of Alzheimer's disease through innate immunological IFITM3 pathway
    Zhang T, Ruan J, Liu Z et al. · Brain Behav Immun · 2025
  10. 10
    Ketogenic Diet Mitigates Age-Related Cognitive Decline and Neuroinflammation in Rats, While Antibiotics Exacerbate Brain Health Risks
    Sayin O, Ilgin R, Akkaya EC et al. · J Mol Neurosci · 2025
  11. 11
    Beta-hydroxybutyrate counteracts the deleterious effects of a saturated high-fat diet on synaptic AMPAR receptors and cognitive performance
    Rojas R, Griñán-Ferré C, Castellanos A et al. · Mol Metab · 2025
  12. 12
    Ketone ester ingestion impairs exercise performance without impacting cognitive function or circulating EPO during acute hypoxic exposure
    Stalmans M, Tominec D, Lauriks W et al. · J Appl Physiol (1985) · 2025RCT
  13. 13
    β-hydroxybutyrate and mitochondria mediate the association between medium-chain fatty acids, DHA and mild cognitive impairment: a nested case-control study
    Yang T, Duan H, Li Y et al. · Nutr Neurosci · 2025
  14. 14
    Multisystem impact of altering acid load of ingested exogenous ketone supplements at rest in young healthy adults
    McClure TS, Buxton JD, Egan B et al. · Am J Physiol Regul Integr Comp Physiol · 2025RCT
  15. 15
    Effect of exogenous β-hydroxybutyrate on BDNF signaling, cognition, and amyloid precursor protein processing in humans with T2D and insulin-resistant rodents
    Baranowski BJ, Oliveira BF, Falkenhain K et al. · Am J Physiol Cell Physiol · 2025RCT
  16. 16
    Effects of Ketone Ester Supplementation on Cognition and Appetite in Individuals with and Without Metabolic syndrome: A Randomized Trial
    Graybeal AJ, Aultman RS, Brandner CF et al. · J Diet Suppl · 2025RCT
  17. 17
    Acute ketone monoester supplementation in young adults: modulating metabolic and neurocognitive functions across body weights
    Yu Q, Wong KK, Lei OK et al. · Appl Physiol Nutr Metab · 2025RCT
  18. 18
    Circulating Ketone Bodies, Pyruvate, and Citrate and Risk of Cognitive Decline, Structural Brain Abnormalities, and Dementia
    Gutierrez-Tordera L, Moseholm KF, Trius-Soler M et al. · Aging Dis · 2024
  19. 19
    Ketone monoester attenuates declines in cognitive performance and oxygen saturation during acute severe hypoxic exposure under resting conditions
    McClure TS, Phillips J, Koutnik AP et al. · Exp Physiol · 2024RCT
  20. 20
    Ketone monoester attenuates oxygen desaturation during weighted ruck exercise under acute hypoxic exposure but does not impact cognitive performance
    McClure TS, Phillips J, Kernagis D et al. · Exp Physiol · 2024RCT
  21. 21
    Beta-Hydroxybutyrate Mitigates Sensorimotor and Cognitive Impairments in a Photothrombosis-Induced Ischemic Stroke in Mice
    Gureev AP, Sadovnikova IS, Chernyshova EV et al. · Int J Mol Sci · 2024
  22. 22
    Integrative Multimodal Metabolomics to Early Predict Cognitive Decline Among Amyloid Positive Community-Dwelling Older Adults
    Tremblay-Franco M, Canlet C, Carriere A et al. · J Gerontol A Biol Sci Med Sci · 2024
  23. 23
    The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats
    Rutkowsky JM, Roland Z, Valenzuela A et al. · Aging (Albany NY) · 2024
  24. 24
    A Ketone Monoester with Carbohydrate Improves Cognitive Measures Postexercise, but Not Performance in Trained Females
    Waldman HS, O'Neal EK, Barker GA et al. · Med Sci Sports Exerc · 2024
  25. 25
    OXCT1 regulates hippocampal neurogenesis and alleviates cognitive impairment via the Akt/GSK-3β/β-catenin pathway after subarachnoid hemorrhage
    Qiu JY, Gao SQ, Chen YS et al. · Brain Res · 2024

Longevity & aging · 158

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  1. 01
    Muscle-Adipose Aging Dynamics and Inflammaging Patterns Across Ethnically Diverse Populations: Exploring Potential Roles of Lipolysis
    Hsiao FY, Wu JC, Chen IT et al. · J Cachexia Sarcopenia Muscle · 2026
  2. 02
    Intermittent Fasting Attenuates Cognitive Decline in D-Galactose-Induced Aging Rats in Association with β-Hydroxybutyrate and PI3K/AKT/GSK-3β Signaling
    Lin X, Huang L, Ling X et al. · Neurochem Res · 2026
  3. 03
    Aging and metabolism in HFpEF: Pathophysiology and therapeutic implications
    Ye M, Feng S, Xu Z et al. · Metabolism · 2026
  4. 04
    The Role of Ketogenic Diet and β-Hydroxybutyrate in the Prevention of Muscle Catabolism and Sarcopenia in Aging Populations: Mechanisms, Evidence, and Clinical Perspectives
    Venturini C, Matacchione G, Mancinelli L et al. · Nutrients · 2026
  5. 05
    β-Hydroxybutyrate Acts as an Exercise Mimetic to Protect the Aging Liver
    Li K, Wang L, Zhu D et al. · Aging Cell · 2026
  6. 06
    Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study
    Stubbs BJ, Stephens EB, Mansfield T et al. · J Frailty Aging · 2025RCT
  7. 07
    Ketone Catabolism Is Essential for Maintaining Normal Heart Function During Aging
    Keller MA, Nakamura M · J Am Heart Assoc · 2025
  8. 08
    Anti-Senescence Effect of Inhibiting Sodium-Glucose Cotransporter 2 and α-Glucosidase in a Type 2 Diabetes Mellitus Animal Model
    Hong S, Kong BS, Lee H et al. · Diabetes Metab J · 2025
  9. 09
    Interplay between age, APOE Ɛ4 and the metabolome in plasma and brain in Alzheimer's disease
    Amin N, Liu J, Sproviero W et al. · Transl Psychiatry · 2025
  10. 10
    Impact of histone post-translational modification inhibitors on lifespan, reproduction, and stress response in the rotifer Brachionus manjavacas
    Luviano Aparicio N, Dryburgh M, McMaken CM et al. · PLoS One · 2025
  11. 11
    Effect of henagliflozin on aging biomarkers in patients with type 2 diabetes: A multicenter, randomized, double-blind, placebo-controlled study
    Zhang J, Cai W, Liu D et al. · Cell Rep Med · 2025RCT
  12. 12
    Ketogenic Diet Mitigates Age-Related Cognitive Decline and Neuroinflammation in Rats, While Antibiotics Exacerbate Brain Health Risks
    Sayin O, Ilgin R, Akkaya EC et al. · J Mol Neurosci · 2025
  13. 13
    Beta-Hydroxybutyrate but not NMN supplementation mimics caloric restriction reducing early mortality in Daphnia
    Pearson AC, Yampolsky LY · Biogerontology · 2025
  14. 14
    TAS2R5 and TAS2R38 are bitter taste receptors whose colonic expressions could play important roles in age-associated processes
    Jalševac F, Segú H, Balaguer F et al. · J Nutr Biochem · 2025
  15. 15
    The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway
    Monterrubio-Ledezma F, Salcido-Gómez A, Zavaleta-Vásquez T et al. · Geroscience · 2025
  16. 16
    Unveiling the Anti-Aging Potential of 3HB: Lifespan Extension and Cellular Senescence Delay
    An Y, Wang Q, Qiao P et al. · Nutrients · 2025
  17. 17
    P46Shc Inhibits Mitochondrial ACAA2 Thiolase, Exacerbating Mitochondrial Injury and Inflammation in Aging Livers
    Li Y, Fan W, Lo TH et al. · Am J Pathol · 2025
  18. 18
    Primary components of MCT ketogenic diet are detrimental to bone loss associated with accelerated aging and age-related neurotoxicity in mice
    Jain S, Vohora D · Bone · 2025
  19. 19
    β-Hydroxybutyrate and Citrate Synthase as Potential Diagnostic Biomarkers in Aging-Related Atrial Fibrillation
    He JK, Jiang XX, Dai SY et al. · J Cardiovasc Transl Res · 2025
  20. 20
    Two-month ketogenic diet alters systemic and brain metabolism in middle-aged female mice
    Roslund KJ, Ramsey JJ, Rutkowsky JM et al. · Geroscience · 2025
  21. 21
    β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
    Madhavan SS, Roa Diaz S, Peralta S et al. · Cell Chem Biol · 2025
  22. 22
    Current situation and challenge of exogenous 3-hydroxybutyrate derived from polyhydroxyalkanoates for elderly health: A review
    Wei DX, Chen Z · Int J Biol Macromol · 2025
  23. 23
    β-Hydroxybutyrate alleviates brain aging through the MTA1 pathway in D-galactose injured mice
    Wang R, Yang X, Wang L et al. · Eur J Pharmacol · 2024
  24. 24
    Rationale and protocol for a safety, tolerability and feasibility randomized, parallel arm, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms
    Stubbs BJ, Alvarez Azañedo G, Peralta S et al. · PLoS One · 2024
  25. 25
    Differences in the Effect of Beta-Hydroxybutyrate on the Mitochondrial Biogenesis, Oxidative Stress and Inflammation Markers in Tissues from Young and Old Rats
    Nesterova VV, Babenkova PI, Brezgunova AA et al. · Biochemistry (Mosc) · 2024

Metabolic health · 1,129

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  1. 01
    Genetics of Response to Canagliflozin (GRC) Study: Rationale, Design, and Pharmacodynamic Responses
    Montasser ME, Bargal SA, Streeten EA et al. · Clin Transl Sci · 2026
  2. 02
    Exercise Metabolic Flexibility in Type 2 Diabetes Treated With Empagliflozin: An Exploratory Analysis of the Randomised Trial EMPA-HEART
    Nesti L, Santoni L, Baldi S et al. · Diabetes Obes Metab · 2026RCT
  3. 03
    Atypical Presentation of New Onset Diabetes with Hyperglycemic Hyperosmolar State in Two Toddlers
    Haque A, Bell-Sambataro EE, Patel F et al. · J Clin Res Pediatr Endocrinol · 2026
  4. 04
    Broad-Spectrum Effects of Carbohydrate Reduction on Inflammatory and Immune Mediators in Type 2 Diabetes
    Athinarayanan SJ, Phinney SD, Adams RN et al. · Endocr Res · 2026
  5. 05
    Combined high-fat, high-sucrose diet and streptozotocin treatment induces cardiometabolic heart failure with preserved ejection fraction in mice
    Heinen A, Spychala A, Ballmann L et al. · Am J Physiol Heart Circ Physiol · 2026
  6. 06
    A novel glucose beta-hydroxybutyrate combination improves hypoglycaemia recovery and patient-reported outcomes in type 1 diabetes
    Russell-Jones D, Smout V, Roy S et al. · Diabetes Obes Metab · 2026RCT
  7. 07
    The prevalence of autoimmune diseases in antibody negative type 1 diabetes mellitus
    Bakjaji S, Lahoti A, Hoffman RP et al. · J Pediatr Endocrinol Metab · 2026
  8. 08
    25-hydroxyvitamin D and the initial presentation of pediatric type 1 diabetes: associations with ketoacidosis severity and beta-cell function
    Ilmer S, Sohail R, Hyman S · Front Endocrinol (Lausanne) · 2026
  9. 09
    BDH1 regulates cardiomyocyte apoptosis and diabetic cardiomyopathy by modulating mitochondrial dynamics and attenuating oxidative stress
    Shi Y, Xu G, Liu S et al. · Cell Signal · 2026
  10. 10
    Community deaths from diabetic ketoacidosis: A 14-year retrospective study in Auckland, New Zealand
    Yeu RQ, Morrow PL, Braatvedt GD · Diabet Med · 2026
  11. 11
    Ketone supplementation dose-dependently lowers postprandial blood glucose, lipid and ghrelin levels in individuals with type 2 diabetes: a randomised crossover study
    Bangshaab M, Bengtsen MB, Smedegaard S et al. · Diabetologia · 2026RCT
  12. 12
    Ketogenic diet sex-dependent effects on rat bone marrow cells during development and β-HB protection in hypoglycemia
    Truchan K, Ilnicki B, Setkowicz Z et al. · Sci Rep · 2026
  13. 13
    Dietary poly-β-hydroxybutyrate optimized by dose-response screening, mitigated high-carbohydrate diet-induced glucose metabolism disorder in topmouth culter (Culter alburnus)
    Li L, Liu J, Cui D et al. · Int J Biol Macromol · 2026
  14. 14
    Ketone monoester ingestion improves endothelial function during hyperglycemia in females with polycystic ovary syndrome
    Berbrier DE, Huckins W, Delage SI et al. · Am J Physiol Endocrinol Metab · 2026RCT
  15. 15
    Examining the causal link between cheese intake and susceptibility to type 2 diabetes through metabolic traits: Insights from Mendelian randomization
    Yang Y, Wang X, Yang W · J Dairy Sci · 2026
  16. 16
    Metformin-related fatalities - The importance of combining forensic toxicology and postmortem biochemistry analyses in death involving antidiabetics
    Drevin G, Leuger L, Renard L et al. · Forensic Sci Int · 2026
  17. 17
    Diabetic ketoacidosis induced by liraglutide overdose for weight loss in a type 2 diabetes patient: A case report
    Xu H, Zhang Y · Medicine (Baltimore) · 2026
  18. 18
    Hepatic HMGCS2-derived β-hydroxybutyrate attenuates hippocampal insulin resistance and neuroinflammation to promote MASLD-induced cognitive function
    Nie L, Sun J, Xu W et al. · Commun Biol · 2026
  19. 19
    BDH1 Mediates Aerobic Exercise-Induced Improvement in Skeletal Muscle Metabolic Remodeling in Type 2 Diabetes Mellitus
    Wu M, Ma X, Dai W et al. · Biomolecules · 2026
  20. 20
    Starvation Ketosis Versus Euglycemic Diabetic Ketoacidosis in Pregnancy: A Case Report Highlighting the Diagnostic Overlap
    Vunnam DS, Moore SE, Pathak RD · WMJ · 2026
  21. 21
    The Effect of Saffron Extract Supplementation During Resistance Training on Hippocampal Doublecortin and Hepatic β-Hydroxybutyrate Levels in Rats With Type 2 Diabetes
    Dehnou VV, Sarghaleh AJ, Karimi A et al. · J Diabetes Res · 2026
  22. 22
    Metabolic responses to 48 h fasting and refeeding in adults with and without obesity
    Sandilands R, Neudorf H, Ursel S et al. · Appl Physiol Nutr Metab · 2026
  23. 23
    Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity
    Hinrichs A, Pafili K, Sancar G et al. · Mol Metab · 2026
  24. 24
    Influence of exogenous ketosis on spontaneous cardiovagal baroreflex gain and blood pressure responses to isometric handgrip in individuals with metabolic syndrome: a placebo-controlled pilot study
    Stavres J, Aultman RS, Brandner CF et al. · Eur J Appl Physiol · 2026RCT
  25. 25
    Immunocytes Play a Crucial Role as Mediators in the Protective Effects of D-β-Hydroxybutyrate Dehydrogenase 1 against Type 2 Diabetes Mellitus: A Mendelian Randomization Study
    Liu YY, Zhang YY, Wan Q · Endocr Metab Immune Disord Drug Targets · 2026