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Studien zu Spermidin (aus Weizenkeim)

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10.735 Studien insgesamt·Stand: 27. Mai 2026Auf PubMed öffnen

Longevity & Aging · 245

Auf PubMed öffnen
  1. 01
    Clostridium butyricum and its metabolite spermidine delay cognitive decline during natural brain aging by reducing inflammation and oxidative stress
    Wu S, Zhang J, Yin Y et al. · Behav Brain Res · 2026
  2. 02
    Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study
    Alsaleh G, Ali M, Kayvanjoo AH et al. · Aging Cell · 2026RCT
  3. 03
    Polyamines and autophagy as a dynamic regulatory network in skeletal muscle regeneration and aging
    Attili L, Rossi MN, Di Santo R et al. · Mech Ageing Dev · 2026
  4. 04
    The Diet-Microbiota-Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications
    Mafe AN, Büsselberg D · Nutrients · 2026
  5. 05
    Anti-aging potential of caffeoyl-spermidine derivatives from Lycium ruthenicum Murr.: insights from UPLC-QTOF-MS/MS, Caenorhabditis elegans, and mechanistic studies
    Shen L, Zhang Y, Ran M et al. · Food Funct · 2026
  6. 06
    Spermidine deficiency induces BNIP3/LC3B-mediated mitophagy in the salivary glands of accelerated aging mice
    Toan NK, Duong MD, Phu ND et al. · Biochim Biophys Acta Gen Subj · 2026
  7. 07
    Polyamine metabolism as a regulator of cellular and organismal aging
    Uemura T, Takayama J, Oguro A et al. · Amino Acids · 2026
  8. 08
    Distinct roles of urolithin A and spermidine in mitophagy and autophagy: implications for dietary supplementation
    Borsky P, Holmannova D, Soukup O et al. · Nutr Res Rev · 2025
  9. 09
    Age-related immune states and PD-1 blockade: mechanisms and strategies for the elderly
    Yaguchi T, Chamoto K, Honjo T · J Immunother Cancer · 2025
  10. 10
    Putrescine functions as a metabolic checkpoint in replication stress-induced senescence
    Vasilogiannakopoulou T, Begou O, Karali CS et al. · Cell Mol Life Sci · 2025
  11. 11
    Dietary and Pharmacological Modulation of Aging-Related Metabolic Pathways: Molecular Insights, Clinical Evidence, and a Translational Model
    Murillo-Cancho AF, Lozano-Paniagua D, Nievas-Soriano BJ · Int J Mol Sci · 2025
  12. 12
    Specific features of immune ageing are detected in the earliest stages in rheumatoid arthritis development
    Raza K, Sharma-Oates A, Padyukov L et al. · EBioMedicine · 2025
  13. 13
    The roles of placental senescence, autophagy and senotherapeutics in the development and prevention of pre-eclampsia: A focus on ergothioneine
    Kell DB, Kell L, Kenny LC et al. · J Reprod Immunol · 2025
  14. 14
    Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges
    Liu Q, Li J, Sun X et al. · J Hematol Oncol · 2025
  15. 15
    The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders
    Zou M, Li D, Yang Y · Ageing Res Rev · 2025
  16. 16
    Bazi Bushen capsule modulates Akkermansia muciniphila and spermidine metabolism to attenuate brain aging in SAMP8 mice
    Zhang S, Mao X, Chang L et al. · J Ethnopharmacol · 2025
  17. 17
    Spermidine supplementation and protein restriction protect from organismal and brain aging independently
    Liang Y, Krivograd A, Hofer SJ et al. · Aging (Albany NY) · 2025
  18. 18
    Spermidine protects cellular redox status and ionic homeostasis in D-galactose induced senescence and natural aging rat models
    Singh S, Verma AK, Garg G et al. · Z Naturforsch C J Biosci · 2025
  19. 19
    A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti-Aging Mechanisms
    Li E, Wang R, Li Y et al. · J Cachexia Sarcopenia Muscle · 2025
  20. 20
    A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing
    Park SH, Choi PG, Kim HS et al. · J Cachexia Sarcopenia Muscle · 2025
  21. 21
    Spermidine alleviates diabetic periodontitis by reversing human periodontal ligament stem cell senescence via mitophagy
    Zhou Y, Wang D, Xiao Q et al. · Free Radic Biol Med · 2025
  22. 22
    Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure
    Yoshida K, Liu Z, Kubo Y et al. · Exp Gerontol · 2025
  23. 23
    The longevity factor spermidine is part of a highly heritable complex erythrocyte phenotype associated with longevity
    Kaminsky CJ, Mill J, Patel V et al. · Aging Cell · 2024
  24. 24
    A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity
    Hofer SJ, Daskalaki I, Abdellatif M et al. · Autophagy · 2024
  25. 25
    Age-Associated Alterations in the Metabolome of Human Vitreous in Bacterial Endophthalmitis
    Maiti S, Gowtham L, Rudraprasad D et al. · Invest Ophthalmol Vis Sci · 2024

Kognition · 24

Auf PubMed öffnen
  1. 01
    Clostridium butyricum and its metabolite spermidine delay cognitive decline during natural brain aging by reducing inflammation and oxidative stress
    Wu S, Zhang J, Yin Y et al. · Behav Brain Res · 2026
  2. 02
    Nasal-to-brain siRNA delivery based on trace amine associated receptor for improving cognitive function
    Cai L, Li S, Wan C et al. · J Control Release · 2025
  3. 03
    Association between dietary spermidine intake and cognitive performance in older adults: The U.S. National Health and Nutrition Examination Survey, 2011-2014
    Ma Y, Qi L, Zhu F et al. · J Affect Disord · 2025
  4. 04
    The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders
    Zou M, Li D, Yang Y · Ageing Res Rev · 2025
  5. 05
    Bazi Bushen capsule modulates Akkermansia muciniphila and spermidine metabolism to attenuate brain aging in SAMP8 mice
    Zhang S, Mao X, Chang L et al. · J Ethnopharmacol · 2025
  6. 06
    Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging
    Wang W, Sun Y, Cao R et al. · Ecotoxicol Environ Saf · 2025
  7. 07
    High Plasma Polyamine Levels Are Associated With an Increased Risk of Poststroke Cognitive Impairment: A Multicenter Prospective Study From CATIS
    He Y, Jia Y, Liu Y et al. · J Am Heart Assoc · 2025RCT
  8. 08
    Cerebroprotein hydrolysate-I ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via the p53/SAT1/ALOX15 signalling pathway
    Ren X, Wen Y, Yuan M et al. · Eur J Pharmacol · 2024
  9. 09
    Effects of lifespan-extending interventions on cognitive healthspan
    Culig L, Sahbaz BD, Bohr VA · Expert Rev Mol Med · 2022
  10. 10
    Elevated spermidine serum levels in mild cognitive impairment, a potential biomarker of progression to Alzheimer dementia, a pilot study
    Sternberg Z, Podolsky R, Nir A et al. · J Clin Neurosci · 2022
  11. 11
    Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial
    Schwarz C, Benson GS, Horn N et al. · JAMA Netw Open · 2022RCT
  12. 12
    Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
    Hofer SJ, Liang Y, Zimmermann A et al. · Autophagy · 2021
  13. 13
    Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy
    Bourourou M, Gouix E, Melis N et al. · J Cereb Blood Flow Metab · 2021
  14. 14
    Dietary spermidine improves cognitive function
    Schroeder S, Hofer SJ, Zimmermann A et al. · Cell Rep · 2021
  15. 15
    Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention
    Mao M, Yang L, Jin Z et al. · Acta Pharmacol Sin · 2021
  16. 16
    Spermidine intake is associated with cortical thickness and hippocampal volume in older adults
    Schwarz C, Horn N, Benson G et al. · Neuroimage · 2020
  17. 17
    Mechanisms by which autophagy regulates memory capacity in ageing
    De Risi M, Torromino G, Tufano M et al. · Aging Cell · 2020
  18. 18
    Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo
    Fischer M, Ruhnau J, Schulze J et al. · Aging (Albany NY) · 2020
  19. 19
    Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial
    Wirth M, Schwarz C, Benson G et al. · Alzheimers Res Ther · 2019
  20. 20
    Cerebrospinal Fluid Spermidine, Glutamine and Putrescine Predict Postoperative Delirium Following Elective Orthopaedic Surgery
    Pan X, Cunningham EL, Passmore AP et al. · Sci Rep · 2019
  21. 21
    The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial
    Wirth M, Benson G, Schwarz C et al. · Cortex · 2018RCT
  22. 22
    Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
    Schwarz C, Stekovic S, Wirth M et al. · Aging (Albany NY) · 2018RCT
  23. 23
    Modulation of learning and memory by natural polyamines
    Guerra GP, Rubin MA, Mello CF · Pharmacol Res · 2016
  24. 24
    Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis-mass spectrometry
    González-Domínguez R, García A, García-Barrera T et al. · Electrophoresis · 2014