Evidence base

Studies on Coenzyme Q10 (Ubiquinol)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

7,997 studies total·Last updated: June 4, 2026Open on PubMed

Energy & endurance · 1,767

Open on PubMed
  1. 01
    Coenzyme Q10 improves redox homeostasis, mitochondrial biogenesis, and irisin signaling in fast- and slow-twitch muscle fibers in a reserpine-induced fibromyalgia-like myalgia model
    Belviranlı M, Okudan N, Sezer T · Life Sci · 2026
  2. 02
    FSP1 reduces exogenous coenzyme Q10 and inhibits ferroptosis to alleviate intestinal ischemia-reperfusion injury
    Shen T, Wang X, Zhang J et al. · J Adv Res · 2026
  3. 03
    Mitochondrial ROS Production at Complexes I and III in Human Myocardium and Skeletal Muscle: A Distinct Pattern Compared with Rat Tissue
    Mihanovic I, Marinovic J, Bulat C et al. · Cells · 2026
  4. 04
    CoQ(0) hysteresis and inhibition of the cytochrome b(5) reductase activity of human Cb(5)R by CoQ(0) and CoQ(10)
    Valerio GN, Martinez-Costa OH, Sanchez-Cabeza C et al. · Free Radic Biol Med · 2026
  5. 05
    Metabolic Reprogramming and Ferroptosis: Unlocking New Therapeutic Frontiers in Cancer and Diabetes
    Huo Y, Xia Y, Zhang Q et al. · Antioxid Redox Signal · 2026
  6. 06
    Melatonin and Coenzyme Q10 mitigate Senescence in Human Adipose-Derived Mesenchymal Stem Cells by Restoring Mitophagy and Mitochondrial Proteostasis
    Vikraman A, Ravi L, Kandasamy N et al. · PLoS One · 2026
  7. 07
    BPM31510 Increases the CoQ Pool in Chemically Induced CoQ-Deficient Cells, CoQ-Deficient Patient Fibroblasts, and in Metabolically Active Murine Tissues
    Aristizabal-Henao JJ, Wessel SR, Stopka SA et al. · FASEB J · 2026
  8. 08
    Modulation of Redox Balance by Phytochemicals: Implications for Cardiovascular Health
    Jaganjac M, Orie NN · Nutrients · 2026
  9. 09
    Impact of Oxidative Stress-Driven Ferroptosis in Neurodegeneration
    Rafique A, Junaid A, Bakovic M · Int J Mol Sci · 2026
  10. 10
    Coenzyme Q(10) Deficiency and Elevated LEAK Mitochondrial Respiration as Potential Heart Failure Markers in Ebstein Anomaly
    Klaučo F, Šimková I, Sumbalová Z et al. · Int J Mol Sci · 2026
  11. 11
    Timing of Redox Imbalances in Cardiac Surgery
    Pooth JS, Böhmerle T, Krawczyk K et al. · Eur J Cardiothorac Surg · 2026
  12. 12
    Reversible Metabolic and Liver Disease in Complex III Deficiency: Novel Variants Expand the Reported UQCRC2-Associated Phenotype
    Preston G, Shammas I, Pinto E Vairo F et al. · Cells · 2026
  13. 13
    Protective Effect of Idebenone Against UVB-Induced Photoaging in HaCaT Cells
    Feng L, Tian L, Guo J et al. · Drug Des Devel Ther · 2026
  14. 14
    Post-catalysis structures of mitochondrial complex I with ubiquinol-10 bound in the active site
    Chung I, Pereira CS, Wright JJ et al. · Nat Commun · 2026
  15. 15
    Purinergic signaling and energetic metabolism in bipolar disorder: From pathophysiology to precision therapeutics
    Malewska-Kasprzak M, Dmitrzak-Weglarz M, Rybakowski F · Psychiatry Res · 2026
  16. 16
    A Novel Link Between Electron Transport Chain Modulation and mcl-PHA Production in Pseudomonas aeruginosa 5300 Using Azide as a Modulator
    Paduvari R, Somashekara D · Environ Microbiol Rep · 2026
  17. 17
    Idebenone protects against doxorubicin-induced cardiac injury by inhibiting ferroptosis in cardiomyocytes
    Mao J, Zhou Z, Xu Y et al. · Exp Gerontol · 2026
  18. 18
    Ferroptosis susceptibility in primary coenzyme Q(10) deficiency: Cellular insights from patient fibroblasts and clinical course of six individuals
    Watanabe C, Miyauchi A, Aoki S et al. · Brain Dev · 2026
  19. 19
    Mitocytosis-inducing nanoparticles alleviate gemcitabine resistance via dual disruption of pyrimidine synthesis and redox homeostasis in pancreatic ductal adenocarcinoma
    Wang Y, Fan H, Chen Q et al. · Biomaterials · 2026
  20. 20
    Metabolomics of Multiple System Atrophy Patient-Derived Striatal Medium Spiny Neurons
    Smandzich NJ, Bähre H, Gschwendtberger T et al. · Biomolecules · 2026
  21. 21
    ALDH2/eIF3E Interaction Modulates Protein Translation Critical for Cardiomyocyte Ferroptosis in Acute Myocardial Ischemia Injury
    Chen X, Yu X, Zhong S et al. · Circulation · 2026
  22. 22
    Alfa-Lipoic Acid and Lipoamide Can Promote Extracellular Coenzyme Q(10) Reduction in Presence of Hep G2 Cells; Involvement of Cell-Mediating α-Lipoic Acid- or Lipoamide-Coenzyme Q(10) Reduction Cycle
    Takahashi T, Okamoto T · J Nutr Sci Vitaminol (Tokyo) · 2026
  23. 23
    Effects of Coenzyme Q10 Supplementation on Depressive Symptoms and Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Magalhães PLM, da Silva AMP, Maximiano MLB et al. · J Clin Psychopharmacol · 2026SR
  24. 24
    FGF21 Promotes Thermogenesis by Browning Thermogenic Adipose Tissue during Cold Exposure
    Li CX, Tan CF, Zhang QM et al. · Ann Nutr Metab · 2026
  25. 25
    Decoding the diet-inflammation nexus: ferroptosis as a therapeutic target
    Zhang Y, Liu Y, Huang Q et al. · Crit Rev Food Sci Nutr · 2026

Cardiovascular · 955

Open on PubMed
  1. 01
    Mitochondrial dysfunction and applications of mitochondrial-targeted delivery systems in atherosclerosis
    Liu Y, Luo N, Xi X et al. · Drug Deliv · 2026
  2. 02
    FSP1 reduces exogenous coenzyme Q10 and inhibits ferroptosis to alleviate intestinal ischemia-reperfusion injury
    Shen T, Wang X, Zhang J et al. · J Adv Res · 2026
  3. 03
    Phenotypic heterogeneity within twins with MELAS with epilepsy: Case report
    Wu H, Wang Y, Kong Q · Medicine (Baltimore) · 2026
  4. 04
    Organic nano-quantum dots of salvianolic acid B modified with photosensitive cypate for the diagnosis and treatment of myocardial ischemia-reperfusion injury
    Wang N, Zhang Y, Huang W et al. · Colloids Surf B Biointerfaces · 2026
  5. 05
    Effect of compound fish oil capsules on microvascular function in hypertensive individuals: a triple-blind, randomized, placebo-controlled pilot trial
    Liu B, Wang W, Teng A et al. · Food Funct · 2026RCT
  6. 06
    Modulation of Redox Balance by Phytochemicals: Implications for Cardiovascular Health
    Jaganjac M, Orie NN · Nutrients · 2026
  7. 07
    Coenzyme Q(10) Deficiency and Elevated LEAK Mitochondrial Respiration as Potential Heart Failure Markers in Ebstein Anomaly
    Klaučo F, Šimková I, Sumbalová Z et al. · Int J Mol Sci · 2026
  8. 08
    Coenzyme Q10 Mitigates Myocardial Infarction by Modulating HDAC4 O-GlcNAcylation
    Xie W, Gao X, Song S et al. · Biofactors · 2026
  9. 09
    Ameliorative Effects of Coenzyme Q10 Against Hypoxia-Induced and Varicocele-Associated Spermatogenesis Dysfunction in Rat
    Chen X, Liu W, Shi J et al. · Andrology · 2026
  10. 10
    Idebenone protects against doxorubicin-induced cardiac injury by inhibiting ferroptosis in cardiomyocytes
    Mao J, Zhou Z, Xu Y et al. · Exp Gerontol · 2026
  11. 11
    Prevention of pressure natriuresis deterioration by dietary coenzyme Q10: Role of mitochondrial preservation in reduced renal mass and high-sodium diet
    Porta DJ, Pasqualini ME, Juncos LI et al. · J Nutr Biochem · 2026
  12. 12
    ALDH2/eIF3E Interaction Modulates Protein Translation Critical for Cardiomyocyte Ferroptosis in Acute Myocardial Ischemia Injury
    Chen X, Yu X, Zhong S et al. · Circulation · 2026
  13. 13
    Metformin and CoQ10 combination therapy: a novel approach to mitigating ischemia-reperfusion injury and cognitive impairment
    Mandloi AS, Sinha VK, Upasani CD et al. · Brain Inj · 2026
  14. 14
    A mitochondria-targeted idebenone derivative W1a mitigates cerebral ischemia-reperfusion injury by preserving mitochondrial integrity and suppressing neuroinflammation
    Li M, Kong D, Ren Q et al. · Bioorg Chem · 2026
  15. 15
    Assessment of a novel functional food modulating the microbiota-inflammation-brain axis in patients with heart failure and/or /atrial fibrillation patients (the AMBROSIA study): Protocol for a randomized controlled trial
    Baldi S, Cuffaro F, Russo E et al. · Contemp Clin Trials · 2026
  16. 16
    Idebenone Attenuates Diabetic Retinopathy by Modulating Autophagy via Targeting Akt Signaling
    Yu Z, Liu G · Curr Med Chem · 2026
  17. 17
    Photobiomodulation in cardiovascular diseases: molecular mechanisms and pharmacological approaches to enhance the therapeutics effects of light
    Oliveira de Moraes LH, Buzinari TC · Lasers Med Sci · 2025
  18. 18
    UQCRB regulates mitochondrial energy metabolism by promoting COX5 A in atherosclerotic endothelial dysfunction
    Dai R, Lei X, Liu X et al. · Naunyn Schmiedebergs Arch Pharmacol · 2025
  19. 19
    Nature's answer to Ferroptosis: how bioactive compounds rewire oxidative stress circuits in cerebral ischemia
    Yi Y, Zhu X, Jia P et al. · Int Immunopharmacol · 2025
  20. 20
    The role of progenitor cells and telocytes in the ameliorative effect of Coenzyme Q10 on isoproterenol-induced cardiotoxicity in rats
    İnal S, Kabak YB · Histochem Cell Biol · 2025
  21. 21
    Developing Intravenous Delivery of Water-Soluble Prodrugs of Idebenone for the Treatment of Acute Ischemic Stroke
    Jia J, Wang H, Wang W et al. · ACS Chem Neurosci · 2025
  22. 22
    Idebenone: Clinical Potential Beyond Neurological Diseases
    Yi B, Zeng J, Li J et al. · Drug Des Devel Ther · 2025
  23. 23
    The protective effects of coenzyme Q10 on blood pressure: a narrative review of anti-inflammatory and antioxidant mechanisms
    Hosseini Roknabadi SM, Abolhassani A, Davoodi E et al. · Inflammopharmacology · 2025
  24. 24
    Oxidation-responsive PEG-poly(α-lipoic acid) nanoparticles for coenzyme Q(10) delivery attenuate hepatic ischemia-reperfusion injury via ROS scavenging and ferroptosis inhibition
    Guan Y, Liu J, Yang J et al. · J Mater Chem B · 2025
  25. 25
    Combined effects of metformin and coenzyme Q10 on doxorubicin-induced cardiotoxicity in male wistar rats
    Mahdizadeh F, Fazaeli A, Rahimi S et al. · Sci Rep · 2025

Longevity & aging · 212

Open on PubMed
  1. 01
    Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals
    Pabis K, Wang W, Selvarajoo K et al. · Aging Cell · 2026
  2. 02
    DRP1 in reproduction and reproductive aging
    Huang CR, Cheng YH, Chang YC et al. · Biol Reprod · 2026
  3. 03
    Melatonin and Coenzyme Q10 mitigate Senescence in Human Adipose-Derived Mesenchymal Stem Cells by Restoring Mitophagy and Mitochondrial Proteostasis
    Vikraman A, Ravi L, Kandasamy N et al. · PLoS One · 2026
  4. 04
    Intravenous longevity therapy: a critical review of evidence, mechanisms, and clinical utility
    Godic A, Townsend J · Acta Dermatovenerol Alp Pannonica Adriat · 2026
  5. 05
    Female reproductive capacity preservation: antioxidant strategies in combating ovarian aging and cryopreservation challenges
    Xie B, Zhang K, Lin J et al. · Front Endocrinol (Lausanne) · 2025
  6. 06
    Edible Bird's Nest as a Multi-Component Functional Food for Brain Aging: From Single-Bioactive Actions to Network-Regulatory Mechanisms
    Gong W, Wang X, Zhang W et al. · Nutrients · 2026
  7. 07
    [The effect of geroprotectors on life expectancy: Mechanisms of action and clinical potential.]
    Petintseva AA, Erdman VV · Adv Gerontol · 2026
  8. 08
    Clinical Strategies for Counteracting Human Ovarian Aging: Molecular Background, Update, and Outlook
    Tesarik J, Mendoza Tesarik R · Int J Mol Sci · 2025
  9. 09
    Unveiling the mechanism of Coenzyme Q10 in ameliorating ageing related oxidative and inflammatory lung alterations in rats via targeting PI3K/AKT/Nrf-2 signaling pathway
    Abdel-Hakeem EA, D M Toni N, Mohamed Elroby Ali D et al. · Arch Physiol Biochem · 2025
  10. 10
    Anti-ageing natural supplements: the main players in promoting healthy lifespan
    Izadi M, Sadri N, Abdi A et al. · Nutr Res Rev · 2025
  11. 11
    Coenzyme Q(10) attenuates age-associated neurodegeneration via modulation of autophagy and neuroinflammation in aged rats
    Srivastava P, Verma AK, Yadawa AK et al. · Metab Brain Dis · 2025
  12. 12
    Effects of lifetime supplementation with ubiquinol 10 on the lifespan and progression of aging in female C57BL/6 mice
    Igarashi Y, Hamada S, Dai J et al. · Exp Gerontol · 2025
  13. 13
    Pharmacologic interventions targeting ovarian aging, cancer, and mitochondrial dysfunction: An updated evidence
    Teppa-Garrán A, Pérez-Peña E, Sobrevia L et al. · Biochim Biophys Acta Mol Basis Dis · 2025
  14. 14
    The aging male: impact of aging on male reproduction
    Akhigbe RE, Oyedokun PA, Adeogun AE et al. · Biogerontology · 2025
  15. 15
    Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy
    Xiang W, Zhang T, Li B et al. · Nat Aging · 2025
  16. 16
    Lactoferrin combined with Coenzyme Q10 ameliorate sarcopenia in an aging mouse model induced by D-galactose
    Wu W, Zhu Y, Fu Y et al. · PLoS One · 2025
  17. 17
    The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging
    Sinha JK, Jorwal K, Singh KK et al. · Mol Neurobiol · 2025
  18. 18
    Mitochondrial transplantation combined with coenzyme Q(10) induces cardioprotection and mitochondrial improvement in aged male rats with reperfusion injury
    Bafadam S, Mokhtari B, Vafaee MS et al. · Exp Physiol · 2025
  19. 19
    SIRT5 -mediated desuccinylation of UQCRC2 attenuates osteogenic differentiation of aged BM-MSCs through impairing mitochondrial homeostasis
    Yin XH, Wang XY, Liu SC et al. · Cell Signal · 2025
  20. 20
    Coenzyme Q(10) supplementation affects cellular ionic balance: relevance to aging
    Srivastava P, Bhoumik S, Yadawa AK et al. · Z Naturforsch C J Biosci · 2025
  21. 21
    Nutritional factors and physical frailty: Highlighting the role of functional nutrients in the prevention and treatment
    Ziaei R, Shahdadian F, Bagherniya M et al. · Ageing Res Rev · 2024
  22. 22
    MiR-125b-1-3p-mediated UQCRB inhibition facilitates mitochondrial metabolism disorders in a rat cellular senescencemodel
    Lu S, Tan C, Xiao X · Mol Cell Probes · 2024
  23. 23
    Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the Development and Lifespan of Marine Nematode Litoditis marina
    Xue Y, Xue B, Zhang L · Int J Mol Sci · 2024
  24. 24
    Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis
    Shang Y, Song N, He R et al. · Adv Nutr · 2024Meta
  25. 25
    Coenzyme Q10 and exercise training reinstate middle cerebral artery occlusion-induced behavioral deficits and hippocampal long-term potentiation suppression in aging rats
    Ranjbar K, Komaki A, Fayazi B et al. · Psychopharmacology (Berl) · 2024