GLP-1 Agonists (Semaglutide, Tirzepatide)
The drug class behind Ozempic, Wegovy & Mounjaro — originally for type-2 diabetes, now highly effective for weight loss. Prescription-only, with growing but still young longevity signals.
⚕ Only under medical supervision
This compound is a prescription drug, or a medication with relevant risks and interactions. We deliberately do not sell it and link no source of supply. Taking it belongs in a doctor's hands — this page is for neutral information only.
Discuss benefits, risks, and dosing with your physician.
How it works
GLP-1 agonists mimic the gut hormone GLP-1: they boost post-meal insulin release, slow gastric emptying, and dampen appetite via the brain. This lowers blood sugar and produces substantial weight loss. Without accompanying resistance training, though, muscle mass is lost too, a key caveat.
Dosage
Weekly injection, titrated up — strictly prescribed and supervised by a physician.
Considerations
For weight loss and type-2 diabetes, efficacy is very well established; trials (SELECT) also show cardiovascular benefit in overweight. The 'longevity' effect so far is indirect — via less visceral fat and better metabolic health; direct lifespan data are lacking. Important caveat: meaningful muscle loss during weight loss (counter with strength training + protein), nausea, rarely pancreatitis. Prescription-only.
