Evidence base

Studies on Turmeric (Curcumin)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

30,698 studies total·Last updated: May 27, 2026Open on PubMed

Joints · 431

Open on PubMed
  1. 01
    Near-infrared reinforced alginate-tyramine-curcumin gels for alleviation of osteoarthritis in an ACLT murine model
    Tsai YT, Tseng YW, Chen YT et al. · J Mater Chem B · 2026
  2. 02
    Pathogenesis of Osteoarthritis: Mechanisms of Action of Disulfidptosis and Targeted Therapeutic Strategies
    Liang Y, Wang K, Yang C et al. · Drug Des Devel Ther · 2026
  3. 03
    Curcumin driven formation of self-cascade nanoclusters from urate oxidase-H(2)S donor conjugates for acute gouty arthritis alleviation
    Ge Y, Rong F, Wang Z et al. · J Control Release · 2026
  4. 04
    Bridging Pharmacology and Nanotechnology: Mechanistic Insights into Traditional Chinese Medicine-Based Nanodelivery Systems for Rheumatoid Arthritis
    Wu Y, Wang P, Wu S et al. · Int J Nanomedicine · 2026
  5. 05
    Dual-drug synergistic nanocomposite hydrogel with inflammation-responsive immunomodulation and BMSC recruitment for enhanced cartilage regeneration
    Du X, Ma Y, Duan X et al. · Int J Biol Macromol · 2026
  6. 06
    Therapeutic efficacy of Curcuma longa leaf extract in experimental models of arthritis
    Anorue EC, Ozougwu VEO, Ogara AL et al. · Inflammopharmacology · 2026
  7. 07
    Targeted delivery of curcumin based on nanocarriers: potential therapeutic strategies for noninfectious arthritis
    Cai B, Cai Y, Wang H et al. · Inflammopharmacology · 2026
  8. 08
    Curcumin Nano-Formulations with Enhanced Bioavailability and Therapeutic Efficacy for Osteoarthritis Treatment
    Zhong F, Zhang J, Teng L et al. · Tohoku J Exp Med · 2026
  9. 09
    A curcumin-borneol prodrug delays rheumatoid arthritis progression by inhibiting the activation of the MAPK/AP-1-MMP9 inflammatory axis
    Xu T, Yang Q, Peng Y et al. · Front Immunol · 2026
  10. 10
    Osteoarthritis and chondrosarcoma: Bioinformatics analysis based on single-cell RNA sequencing and molecular docking
    Hao Z, Qu R, He W · Adv Clin Exp Med · 2026
  11. 11
    Evaluating the efficacy and safety of Curcuma longa, Boswellia serrata, and their mixed formulation in treating knee osteoarthritis: A systematic review and network meta-analysis
    Inprasit C, Bunyamahote S, Boonpattharatthiti K et al. · Complement Ther Med · 2026SR
  12. 12
    Synergistic Effects of Nutritional Formula on Joint Inflammation Through Modulation of Bone Metabolism in Rats
    Wang H, Wang Y, Fan D et al. · Nutrients · 2026
  13. 13
    A quality by design strategy to develop curcumin and siRNA co-loaded lipoplexes to target osteoarthritis-related inflammation and oxidative stress
    Ranamalla SR, Tefas L, Porfire A et al. · Int J Pharm · 2026
  14. 14
    Acid neutralization and metal-phenolic nanomedicine on-demand release microspheres for reversing cartilage degeneration
    Wang S, Gao Y, Dong L et al. · J Control Release · 2026
  15. 15
    Nutritional Interventions in Osteoarthritis: Mechanisms, Clinical Evidence, and Translational Opportunities
    Patel M, Betanzos G, Troka M et al. · Nutrients · 2026
  16. 16
    Curcumin for the clinical treatment of rheumatoid arthritis: a systematic review and meta-analysis of placebo-controlled randomized clinical trials
    Fan Y, Yi Z, Mao S et al. · Front Immunol · 2025SR
  17. 17
    The Protective Role of Curcumin in Osteoarthritis: Establishing Mitochondrial Homeostasis Through Autophagy Induction and Apoptosis Inhibition
    Raja K, Patnaik R, Suresh D et al. · Int J Mol Sci · 2026
  18. 18
    Phytochemicals and nanoformulation strategies for rheumatoid arthritis: mechanistic insights, therapeutic advances, and translational challenges
    Rahmanian M, Khosropanah S, Moghaddam SH et al. · Inflammopharmacology · 2026
  19. 19
    Exploring the beneficial effects of curcumin-based hydrogel beads in rats with rheumatoid arthritis induced by Freund's complete adjuvant
    Djordjevic K, Pindovic B, Mihajlovic K et al. · Mol Cell Biochem · 2026
  20. 20
    Effects of curcumin and Curcuma longa extract on inflammatory biomarkers in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE): a systematic review and meta-analysis of randomized controlled trials
    Liu AJ, Wu PC, Chen YP et al. · Inflamm Res · 2025SR
  21. 21
    Lipid-chitosan hybrid nanoparticles for transdermal co-delivery of lornoxicam and curcumin in arthritis management
    Khan A, Madni A, Khan NR et al. · Int J Biol Macromol · 2025
  22. 22
    Folate-guided AIE nanoparticles integrate macrophage-targeted fluorescence imaging and photodynamic immunomodulation in rheumatoid arthritis
    Wang X, Liu X, Chen J et al. · Colloids Surf B Biointerfaces · 2025
  23. 23
    Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a preclinical approach to rheumatoid arthritis management
    Gharat S, Momin M, Panchal U et al. · Drug Deliv · 2025
  24. 24
    Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3/autophagy signaling pathway to enhance joint homeostasis for osteoarthritis therapy
    Zhang R, Huang L, Jin M et al. · Stem Cell Res Ther · 2025
  25. 25
    Effect of curcumin on inflammatory markers and disease activity in patients with rheumatoid arthritis: A meta-analysis
    Zhang F, Niu B · Medicine (Baltimore) · 2025Meta

Longevity & aging · 303

Open on PubMed
  1. 01
    Computational exploration of squalene analog 4,4'diapophytofluene as a potential anti-aging phytotherapeutic
    Dutta M, Hazra A, Mandal Biswas S · Comput Biol Chem · 2026
  2. 02
    Lipid- and Polymer-Based Nanoscale Delivery of Anti-Aging Phytochemicals
    Gross S, Vogtlander C, Lewis C et al. · Wiley Interdiscip Rev Nanomed Nanobiotechnol · 2026
  3. 03
    Integrated omics analysis reveals the age-dependent dynamic changes of gut microbiota and metabolites in layer chickens
    Su Y, Mai X, Wang Z et al. · Poult Sci · 2026
  4. 04
    Dietary Polyphenols in Aging: A Systems-Level Perspective on Mitochondrial Quality Control and Microbiome Interactions
    Yılmaz A, Park HJ, Ahn EM et al. · Int J Mol Sci · 2026
  5. 05
    Bisdemethoxycurcumin extends lifespan and healthspan in Caenorhabditis elegans via modulation of EGFR-linked signaling pathways
    Shi R, Zhang Y, Li C et al. · Food Funct · 2026
  6. 06
    Senescence as a Central Node in Alzheimer's Disease: Molecular Triggers, Cellular Effectors, and RNA-Based Interventions
    Some A, Naskar N, Thomas DM et al. · Neurochem Res · 2026
  7. 07
    Natural senotherapeutics in respiratory health: Addressing cellular senescence, inflammaging, and immunosenescence in the aging lung
    Juan ME, Verdaguer E, Prohens R et al. · Eur J Pharmacol · 2026
  8. 08
    Edible Bird's Nest as a Multi-Component Functional Food for Brain Aging: From Single-Bioactive Actions to Network-Regulatory Mechanisms
    Gong W, Wang X, Zhang W et al. · Nutrients · 2026
  9. 09
    Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways to Age-Related Pathologies and Therapeutic Perspectives
    Gromadzka G, Tarnacka B, Cieślik M · Int J Mol Sci · 2026
  10. 10
    Curcumin attenuates PM2.5-triggered pulmonary senescence via the mTOR/S6K1 signaling pathway
    Liu K, Shi M, Li X et al. · Biogerontology · 2026
  11. 11
    [The effect of geroprotectors on life expectancy: Mechanisms of action and clinical potential.]
    Petintseva AA, Erdman VV · Adv Gerontol · 2026
  12. 12
    Klotho, Kidneys, and Micronutrient Signaling: A Promising Paradigm for Healthy Aging
    Mahdavi S · Lifestyle Genom · 2026
  13. 13
    Anti-ageing natural supplements: the main players in promoting healthy lifespan
    Izadi M, Sadri N, Abdi A et al. · Nutr Res Rev · 2025
  14. 14
    Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3/autophagy signaling pathway to enhance joint homeostasis for osteoarthritis therapy
    Zhang R, Huang L, Jin M et al. · Stem Cell Res Ther · 2025
  15. 15
    Modulation of Toll-like Receptors with Natural Compounds: A Therapeutic Avenue Against Inflammaging?
    Andrei C, Pușcașu C, Nitulescu GM et al. · Int J Mol Sci · 2025
  16. 16
    A Systematic Review of Food-Derived DNA Methyltransferase Modulators: Mechanistic Insights and Perspectives for Healthy Aging
    Campisi M, Cannella L, Visioli F et al. · Adv Nutr · 2025SR
  17. 17
    Exploring the effects of a multicomponent phytoceutical health product in a Drosophila melanogaster ageing and repetitive concussion model
    Alanazi N, Fraysse A, English EA et al. · J Pharm Pharmacol · 2025
  18. 18
    Quantification of In Vitro Replicative Lifespan Elongation Activity of Pharmaceuticals, Natural Products and Radiation Using the "Overlay" Method
    Acra AM, Sakagami H, Uota S et al. · In Vivo · 2025
  19. 19
    Plant-based strategies against aging: Focus on bioactive compounds from medicine-food homology plants
    Zhu YF, Wu AG, Chen MY et al. · Phytomedicine · 2025
  20. 20
    Targeting cognitive aging with curcumin supplementation: A systematic review and meta-analysis
    Yu L, Li N, Li B et al. · J Prev Alzheimers Dis · 2025SR
  21. 21
    Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency
    Lagoa R, Rajan L, Violante C et al. · Biotechnol Adv · 2025
  22. 22
    Curcumin analog C1 activates autophagy through a TFEB-dependent mechanism to protect sensory hair cells from oxidative stress in C57BL/6 mice with age-related hearing loss
    He W, Wu F, Liu W et al. · Int Immunopharmacol · 2025
  23. 23
    Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise
    Falvino A, Bonanni R, Tarantino U et al. · Int J Mol Sci · 2025
  24. 24
    Effect of curcumin on cardiometabolic diseases in the elderly: A systematic review of randomized controlled trials
    Rajabinasab F, Tabatabaei FSA, Kheirandish A et al. · Ageing Res Rev · 2025SR
  25. 25
    Salutary effects of transdermal curcumin on multiple indices of health span in rodent models of normal aging and hypertension
    Mao K, Wang R, Karpoff K et al. · Geroscience · 2025

Cardiovascular · 977

Open on PubMed
  1. 01
    Comprehensive evaluation of nanodrug CeO(2)@PDA-curcumin for ischemic stroke induced by ischemia-reperfusion injury: In vitro and in vivo studies
    Chen J, Xie L, Zhang C et al. · Biomater Adv · 2026
  2. 02
    Targeting the TLR4/PAD4-mediated formation of macrophage extracellular traps by curcumin attenuates plaque destabilization in ulcerative colitis-associated atherosclerosis
    Li X, Qiu T, Wei Y et al. · Int Immunopharmacol · 2026
  3. 03
    Curcumin Alleviates Myocardial Ischaemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis via the Nrf2/HO-1 Pathway: An Integrated Network Pharmacology and Experimental Study
    Yao L, Qin J, Shen J et al. · Basic Clin Pharmacol Toxicol · 2026
  4. 04
    Healing the heart naturally: The role of bioactive phytocompounds in cardiovascular therapeutics
    Anand A, Srivastava S, Sharma D et al. · Phytomedicine · 2026
  5. 05
    Bridging acute-chronic myocardial infarction treatment: Dual-regulating of ROS/fibrosis via microenvironment-responsive release of NO and curcumin
    Zhang F, Zhao B, Lu K et al. · Biomaterials · 2026
  6. 06
    Curcumin attenuates heatstroke-induced myocardial injury and ventricular arrhythmias by regulating the BAX/BCL-2/caspase-3 pathway
    Shao S, Tang B, Liang J et al. · Food Funct · 2026
  7. 07
    Deep neurotherapeutic strategy for ischemic stroke via focused ultrasound-enhanced delivery of curcumin-loaded antioxidant nanoliposomes
    Su TY, Chang MY, Huang GT et al. · Biomater Sci · 2026
  8. 08
    Antihypertensive Plants Used by the Anak Dalam Tribe in Jambi, Indonesia: Ethnobotanical Insights and Pharmacological Potential as Alternatives to Conventional Medicine
    Muhaimin M, Lestari U, Hirzan R et al. · Drug Des Devel Ther · 2026
  9. 09
    SIRT1 in Cardiac Diseases: Molecular Mechanisms, Therapeutic Potential, and Future Directions
    Chang Y, Li L, Yue H · Int J Mol Sci · 2026
  10. 10
    Curcumin Alleviates Vascular Cognitive Impairment by Inhibiting Ferroptosis Through Regulating the SIRT1/Nrf2/HO-1 Pathway
    Zhuang L, Xu S, Cheng L et al. · Eur J Neurosci · 2026
  11. 11
    Combined melatonin and curcumin treatment ameliorates renal ischemia-reperfusion injury via reducing oxidative stress, inflammation, and apoptosis in rats
    Topkaraoglu S, Sapmaz T, Sevgin K et al. · Biotech Histochem · 2026
  12. 12
    Curcumin augments mitophagy via Nrf2-PINK1-mediated, Parkin-dependent ubiquitination to suppress ferroptosis in post-cardiac arrest brain injury
    Li Z, Xu W, Ren S et al. · Phytomedicine · 2026
  13. 13
    Caveolin-1 regulates cellular cholesterol homeostasis and its potential as an atherosclerosis therapy target
    Peng Y, Chen S, Yu Y et al. · J Steroid Biochem Mol Biol · 2026
  14. 14
    Synthesis, characterization, and nanoparticle formulation and evaluation of rosuvastatin-curcumin conjugate for atherosclerosis management
    Rawat V, Rao SP, Sarwa KK et al. · Bioorg Chem · 2026
  15. 15
    Biomimetic Microenvironment Nanomodulators for Reactive Oxygen Species-Responsive T(1)-T(2) Dual-Modal Magnetic Resonance Imaging and Visualized Treatment of Atherosclerosis
    Liu X, Wan S, Yao T et al. · ACS Nano · 2026
  16. 16
    Identification of mitochondrial dysfunction-related biomarkers and immune infiltration in liver ischemia-reperfusion injury via integrated bioinformatics and machine learning
    Chen X, Zhou Y, Zhang Z et al. · Biochem Biophys Res Commun · 2026
  17. 17
    Biogenic AuNP-Loaded Electroconductive Hydrogels: A Multifunctional Therapeutic Strategy for Isoproterenol-Induced Myocardial Infarction
    Zhao C, Yang Y, Yang B et al. · J Biomed Mater Res B Appl Biomater · 2026
  18. 18
    Peroxisome Proliferator-activated Receptors in Diabetic Retinopathy: Pathophysiologic Insights and Emerging Pharmacologic Strategies
    Mandujano-Ferrer L, Alemán-González-Duhart D · Can J Diabetes · 2026
  19. 19
    ROS-responsive diselenide exosomes restore mitophagy to resolve sterile inflammation in liver IRI
    Zhou T, Jiang Z, Hu Q et al. · Eur J Pharm Sci · 2026
  20. 20
    Curcumin nanoparticles attenuate sepsis-induced myocardial injury by modulating the Nrf2/HO-1/SLC7A11/GPX4 and ACSL4/LPCAT3 pathways
    Wang Y, Zhang H, Liu J et al. · Pathol Res Pract · 2026
  21. 21
    Therapeutic Potential and Mechanisms of Curcumin in Cardiovascular Diseases: A Comprehensive Review
    Nourmohammad A, Zonoubi N, Ghavamikia N · Phytochem Anal · 2026
  22. 22
    Curcumin-Loaded Tetrahedral Framework Nucleic Acids Alleviate Pulmonary Hypertension by Regulating Multiple Synergistic Signaling Pathways
    Yue X, Lan J, Yang L et al. · Adv Healthc Mater · 2026
  23. 23
    NRF2-mediated anti-ferroptotic pathways in diabetic cardiomyopathy: Mechanistic insights, therapeutic advances, and challenges in cardiovascular protection
    Khan SU, Halawi MH, Almehmadi M et al. · Curr Probl Cardiol · 2026
  24. 24
    Effect of DL0410 and tetrahydrocurcumin (LG0367) alone and in combination on learning and memory in vascular dementia
    Guo P, Zhao J, Wang C et al. · Eur J Pharmacol · 2026
  25. 25
    Nature's Bioactives in Cardiorenal Syndrome: Polyphenols at the Crossroads-Preclinical Insights into Redox, Inflammation, and Mitochondrial Protection
    Carollo C, Ciuppa ME, Sorce A et al. · Nutrients · 2026