Evidence base

Studies on L-Lysine

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

91,012 studies total·Last updated: May 27, 2026Open on PubMed

Immune system · 4,447

Open on PubMed
  1. 01
    HLA-B27-associated gut microbiota and amino acid perturbations promote ankylosing spondylitis through M1 macrophage activation
    Huang T, Yang H, Zhang L et al. · Gut Microbes · 2026
  2. 02
    Abolishing PorB-induced mitophagy enhances gonococcal outer membrane vesicle vaccine efficacy
    Ge H, Qin Y, Song S et al. · Emerg Microbes Infect · 2026
  3. 03
    TOR3A represses type I interferon production and limits viral clearance during respiratory syncytial virus infection
    Li X, Chen Z, Wu M et al. · Emerg Microbes Infect · 2026
  4. 04
    Regulatory role of MRTF-A in macrophage polarization and the therapeutic mechanism of Bushen Wenyang Huayu decoction in endometriosis
    Meng X, Qi J, Yang X et al. · J Ethnopharmacol · 2026
  5. 05
    Spatiotemporal controls of neutrophil extracellular traps boosts neutrophils immunotherapy efficiency against solid tumors
    Jin L, Chen L, Xue Y et al. · Biomaterials · 2026
  6. 06
    The acetylation status and metabolic characterization of the HBV-induced macrophages
    Sun Z, Wu S, Luo Y et al. · J Proteomics · 2026
  7. 07
    Nanoscale Fluorescent Characterizations and Origin Tracing of Extracellular Vesicles through Standard Preparation Methods
    Herath HDW, Jing H, Li M et al. · ACS Nano · 2026
  8. 08
    SIRT6-mediated immunometabolic reprogramming of macrophages drives neutrophilic asthma via LDHA-dependent glycolysis
    Su G, Peng J, Quan J et al. · Cell Rep · 2026
  9. 09
    Lactate Uptake by MCT4 Facilitates Stability and Suppressive Function of Tumor-Infiltrating Regulatory T Cells by Promoting Foxp3 Lactylation
    Wu Z, Liu Y, Xian W et al. · Int J Mol Sci · 2026
  10. 10
    Tanshinone IIA alleviates chronic endometritis via DRAK2 inhibition to restore mitochondrial function and suppress KDM3A-SLC2A3-driven NETs formation
    Zou Z, Li Z, Yin F et al. · J Mol Histol · 2026
  11. 11
    TRIM25 promotes antiviral innate immune response by stabilizing IRF7 and its nuclear translocation
    Wu Z, Cui Y, He Y et al. · mBio · 2026
  12. 12
    Glycyl-L-histidyl-L-lysine-Cu2(+) (GHK-Cu) Attenuates CuSO(4) or LPS induced-inflammation in Zebrafish larvae model
    Hu J, Zhang C, Wang F · Eur J Pharmacol · 2026
  13. 13
    Interplay between membrane protrusive activities and their adhesion strength regulates cell migration
    Ghosh I, Mallick D, Sen A et al. · Mol Biol Cell · 2026
  14. 14
    H3K27me3-Mediated Epigenetic Silencing of FgHMG1 Enables Fungal Host Immune Evasion
    Zhao X, Yuan B, Ma P et al. · Plant Biotechnol J · 2026
  15. 15
    Histone Lactylation in Immune Cells and Its Predictive Role in Sepsis Progression: A Prospective Observational Study
    Guo Y, Chu L, Shui W et al. · Shock · 2026
  16. 16
    Methyltransferase SETD7 as a Regulator of STING-Dependent Cytokine Response in Lung Cancer Cells
    Nevzorov IA, Korableva P, Shuvalov O et al. · Int J Mol Sci · 2026
  17. 17
    Expression of lactylation-related genes and their correlation with diabetic foot ulcer occurrence and immune infiltration
    Hu X, Zhou J, Guo M et al. · Front Immunol · 2026
  18. 18
    Lactate Enhances CD8(+) T Cell Cytotoxicity Through H3K9la Upregulation to Drive Vitiligo Pathogenesis
    Yin H, Xu Y, Huang L et al. · Int J Mol Sci · 2026
  19. 19
    Duck plague virus LORF2 utilizes RNF34 to inhibit antiviral innate immunity by ubiquitination and degradation of IRF7
    Tian Y, Tian B, Ran R et al. · PLoS Pathog · 2026
  20. 20
    Mucosal Gingipain Vaccine Based on Framework Nucleic Acid Engineering for the Treatment of Periodontitis
    Qin X, Zhang Z, Wei T et al. · ACS Appl Mater Interfaces · 2026
  21. 21
    Lysine Acetyltransferase 6A Drives M1 Macrophage Polarization Through Metabolic Reprogramming in Sepsis-Induced Acute Lung Injury
    Wang X, Chen J, Lai Y et al. · Biomolecules · 2026
  22. 22
    ATF2-LPCAT1-mediated PKM2 acetylation links cholesterol stress to macrophage metabolic reprogramming and functional remodeling
    Cao H, Ma S, Tian M et al. · Biochem Biophys Res Commun · 2026
  23. 23
    Obesity Disrupts H3K4me3-Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages
    Takahashi K, Drolet J, Liu J et al. · FASEB J · 2026
  24. 24
    Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression
    Kuprasertkul N, Moore AF, D'souza CA et al. · J Clin Invest · 2026
  25. 25
    Co-expression of CCR7 and H3K9me3 identifies aggressive B-cell lymphoma with bone marrow infiltration and poor prognosis
    Chen J, Liu Z, Huang K et al. · Eur Cytokine Netw · 2026

Skin · 699

Open on PubMed
  1. 01
    Proteome analysis of lysine crotonylation modification in patients with psoriasis
    Dong P, Hao C, Li H et al. · PeerJ · 2026
  2. 02
    Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar
    Yuan Y, Xiao Y, Zou J et al. · Nat Commun · 2026
  3. 03
    Targeting KAT8 alleviates self-RNA-driven skin inflammation by modulating histone H4 lysine 16 acetylation in psoriasis
    Xiang Y, Jiang Y, Wang Z et al. · Cell Death Differ · 2026
  4. 04
    Multi-functional antibacterial bio-Patch based on modified hyaluronic acid for skin infected incision repair
    Chen Y, Wen W, Wang J et al. · Int J Biol Macromol · 2026
  5. 05
    Refining of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) for in vitro skin sensitization: A novel predictive model based on decision tree
    Luo F, Liao W, Xing S et al. · Food Chem Toxicol · 2026
  6. 06
    Incorporating Stem Cell-Derived Small Extracellular Vesicles into a Multifunctional OHAMA-EPL Hydrogel Spray for Rapid Healing of Infected Skin Wounds
    He M, Wei Y, Chen X et al. · Adv Healthc Mater · 2025
  7. 07
    Modeling skin sensitization: hierarchical support vector regression-based prediction of lysine depletion in DPRA
    Ta GH, Leong MK · Chem Biol Interact · 2025
  8. 08
    Integrative analysis of inhibition of advanced glycation end-products accumulation and prevention of aging muscle deterioration in animals and human models
    Lee MJ, Park JH, Hong SM et al. · Exp Gerontol · 2025
  9. 09
    Substitution of a proline residue in the frog skin host-defense peptide, figainin-2PL by D-lysine generates an analog with potent activity against antibiotic-resistant ESKAPE pathogens
    Guilhaudis L, Cunning TS, Delaney JJ et al. · Peptides · 2025
  10. 10
    Chelation of cerium (III) with fish skin collagen peptides: Improving the in vitro stability and bioavailability of inorganic cerium
    Wu P, Tu Z, Wang H et al. · Food Res Int · 2025
  11. 11
    Keratinocyte-specific H4K12 lactylation drives a non-canonical IL-17-dependent signaling in psoriasis progression in mice
    Shen X, Qiao W, Yan W et al. · Nat Commun · 2025
  12. 12
    Label-free and real-time monitoring of photoaging with high spatiotemporal resolution using an nIR fluorescent nanosensor array
    Cho Y, Baek H, Koh D et al. · Sci Adv · 2025
  13. 13
    Lysine-Leucine-Rich Frog Skin Antimicrobial Peptides Inhibit Breast Cancer Metastasis by Reprogramming Tumor-Associated Macrophage Polarization
    Li Z, Zhou X, Dong W et al. · Int J Mol Sci · 2025
  14. 14
    Assessment of the Curative Anti-Glycation Properties of a Novel Injectable Formulation Combining Dual-Weight Hyaluronic Acid (Low- and Mid/High-Molecular Weight) with Trehalose on Human Skin Ex Vivo
    Chmielewski R, Lebiedowska A, Barańska-Rybak W · Int J Mol Sci · 2025
  15. 15
    Beneficial impact of MTGase-modified fish gelatin on collagen supplementation in rats: Insights from serum metabolomics and gut microbiota
    Peng CY, Fang T, Lin HB et al. · Food Res Int · 2025
  16. 16
    Novel design of pyrrolidonecarboxylic acid and sodium dilauramidoglutamide lysine complex for targeted drug delivery to human stratum corneum
    Fujii MY, Manabe H, Ogura T · Int J Pharm · 2025
  17. 17
    Increasing collagen synthesis in fibroblasts: The roles of PCL microspheres and the SAMD11-PLOD1 axis in skin rejuvenation
    Cao M, Tao L, Zhang Y et al. · Biochim Biophys Acta Mol Cell Res · 2025
  18. 18
    Fish and bovine collagen promote higher migration and adhesion of dermal cells pre-treated with wound-healing herbal extracts
    Rejeb M, Lahmar A, Ghedira MB et al. · Tissue Cell · 2025
  19. 19
    Bioderived Green Algae Metabolite as a Latent Cross-Linking Agent for Protein-Based Hydrogels with High Potential for Skin Repair Applications
    Melilli G, Rousselle P, Mehiri M et al. · ACS Appl Bio Mater · 2025
  20. 20
    A Novel Butyrate Derivative, Zinc Dibutyroyllysinate, Blunts Microphthalmia-Associated Transcription Factor Expression and Up-Regulates Retinol and Differentiation Pathway mRNAs in a Full-Thickness Human Skin Model
    Swindell WR, Bojanowski K, Quijas G et al. · Int J Mol Sci · 2025
  21. 21
    Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing
    Li F, Ye H, Li L et al. · Pharmacol Res · 2025
  22. 22
    Qualitative Changes in Collagen Induced by UV Irradiation Affect Its Interaction with Cells
    Asari A, Sakaue H, Kumagai T et al. · Biol Pharm Bull · 2025
  23. 23
    Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes?
    Ogórek K, Nowak K, Wadych E et al. · Molecules · 2025
  24. 24
    A robust bio-based polyurethane employed as surgical suture with help to promote skin wound healing
    Wang J, Liu Z, Qiu H et al. · Biomater Adv · 2025
  25. 25
    Estimation of the Skin Sensitization Potential of Chemicals of the Acyl Domain Using DFT-Based Calculations
    Limluan P, Gleeson MP, Gleeson D · Chem Res Toxicol · 2024