Evidence base

Studies on Metformin

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

35,249 studies total·Last updated: June 4, 2026Open on PubMed

Metabolic health · 15,847

Open on PubMed
  1. 01
    Placental CD4⁺ T cells from women with gestational diabetes recapitulate disease features in a pregnant rat model, improved by metformin or mitotempo
    Frieson D, Vel J, Johnson T et al. · Hypertens Pregnancy · 2026
  2. 02
    Qigui didang decoction alleviates renal injury in a diabetic kidney disease model with metabolic memory features: association with ferroptosis and the SIRT1/Nrf2 pathway
    Wu Y, Fan L, You H et al. · Pharm Biol · 2026
  3. 03
    Annual pharmacy cost per patient achieving composite treatment endpoints: a cost to target analysis of tirzepatide versus subcutaneous semaglutide 1 mg in patients with type 2 diabetes in the UK
    Kanumilli N, Osumili B, Evans J et al. · J Med Econ · 2026
  4. 04
    Clinical benefits and cost saving of achieving composite treatment targets for type 2 diabetes - A modeling study
    Si S, Wang R, Li J et al. · J Med Econ · 2026
  5. 05
    Comparing measured and reported change in gastrointestinal symptoms after initiation of metformin treatment: a questionnaire validation study
    Af Geijerstam P, Wenemark M, Daka B et al. · Scand J Prim Health Care · 2026
  6. 06
    Harnessing mitohormesis: A thiazole-based mitochondrial respiration inhibitor restores metabolic homeostasis in type 2 diabetes
    Zhang Y, Guo J, Jin J et al. · Bioorg Chem · 2026
  7. 07
    A biomimetic in vitro glomerular filtration barrier model for investigating renal barrier dysfunction in hyperglycemia
    Kiranmai G, Kaki S, Chameettachal S et al. · Biomater Adv · 2026
  8. 08
    Metformin is associated with the suppression of the TNF-α/iNOS/TIMP-1 axis-mediated liver injury and fibrosis secondary to diabetes
    Zafrah H, Alqahtani SA, Al-Hashem F et al. · Tissue Cell · 2026
  9. 09
    GSTK1 alleviates ectopic fat deposition as a protective mechanism against diabetic renal tubulointerstitial lesions
    Chen H, Liu Y, Zhao MG et al. · Life Sci · 2026
  10. 10
    Network pharmacology study and preclinical validation highlight the anti-diabetic potential of Persicaria lapathifolia (L.) Delarbre leaf extract via AMPK/Akt pathways
    Mehta P, Saha D, Das BK · Bioorg Chem · 2026
  11. 11
    Structure-guided design of aspalathin-inspired chalcone analogs as direct AMPK activators with superior antihyperglycemic and hepatorenal protective effects
    Bojja KS, Holla H, Gawli K · Bioorg Chem · 2026
  12. 12
    Digital twin technologies for supporting self-care in adults with diet-related chronic conditions: a systematic review
    Saeedian Y, Wright C, Jansons P et al. · Int J Med Inform · 2026SR
  13. 13
    Synthesis, and pharmacological evaluation of iminoguanidine derivatives: Identification of FuBIG showing protective effects against diabetic neuroinflammation with a favorable lactate metabolism profile
    Xin M, Zou Z, Song X et al. · Eur J Med Chem · 2026
  14. 14
    The Duodenal Mucosa Plays a Key Role in Metabolic Regulation: Emerging Physiology and New Opportunities for Cell-Directed and Barrier-Related Interventions for the Treatment of Diabetes and Obesity
    D'Alessio DA, Campbell JE · Diabetes Obes Metab · 2026
  15. 15
    Efficacy and safety of anagliptin added to metformin and empagliflozin 25 mg in patients with type 2 diabetes: a 24-week randomized, double-blind, placebo-controlled phase 3 trial with 28-week open-label extension
    Moon JS, Han KA, Yu JM et al. · Diabetes Res Clin Pract · 2026RCT
  16. 16
    Wu-Mei-Wan retards NAFLD progression by ameliorating obesity and regulating serum metabolites in high-fat diet-fed mice
    Guo M, Zhou X, Zhang H et al. · Pak J Pharm Sci · 2026
  17. 17
    Glucose metabolism's impact on Blastocystis presence in the human gut
    Paulí S, Rosell-Díaz M, Moreno-Navarrete JM et al. · Clin Nutr · 2026
  18. 18
    Evaluating Cost-Effectiveness in Relation to the Supporting Clinical Evidence Across the Type 2 Diabetes Continuum: A Review of Metformin and SGLT2is
    Campbell IW, Brand KMG, Gottwald-Hostalek U et al. · Adv Ther · 2026
  19. 19
    A spatiotemporally programmed, matrix metalloproteinase-9-responsive hyaluronic acid/polyglutamate hydrogel for accelerating chronic diabetic wound healing
    Wang C, Liu Q, Wang N et al. · Carbohydr Polym · 2026
  20. 20
    Cardiorenal protective effects of anti-diabetic drugs in early stage Cardiovascular-Kidney-Metabolic Syndrome: A multicenter, time-varying analysis
    Hao WR, Liu JC, Fang YA et al. · Diabetes Res Clin Pract · 2026
  21. 21
    Paternal use of metformin and risk of major congenital malformations: A meta-analysis of 4 studies
    Damkier P, van Gelder MMHJ, Huybrechts KF et al. · Br J Clin Pharmacol · 2026Meta
  22. 22
    Comparison of the Continuous Glucose Monitoring Profiles of Four Glucose-Lowering Medications in the GRADE Randomized Trial
    Bergenstal RM, Crandall JP, Rosin SP et al. · Diabetes Care · 2026RCT
  23. 23
    Clinical trends in Catalonia's Primary Care Setting (2018-2023) in Elderly (≥75 years) and Frail Adults with Type 2 Diabetes
    Ramon-Granés M, Fernàndez-Camins B, Lapena-Estella C et al. · Prim Care Diabetes · 2026
  24. 24
    Metabolic dysfunction and the use of adjunct medications in type 1 diabetes
    Luk A, Cheah YS, Misra S et al. · Curr Opin Endocrinol Diabetes Obes · 2026
  25. 25
    Efficacy and Safety of Fixed-Dose Combinations of Sitagliptin and Empagliflozin as Add-On to Metformin in Korean Patients With Type 2 Diabetes: A Randomised, Double-Blind, Multi-Centre, Placebo-Controlled, Phase III Trial
    Lim S, Kim TN, Mok JO et al. · Diabetes Obes Metab · 2026RCT

Longevity & aging · 591

Open on PubMed
  1. 01
    Concept and connotation of the geroprotective and anti-aging effects of metformin: From AMPK activation to SASP suppression
    Aedh AI, Al-Kuraishy HM, Shokr MM et al. · Mol Cell Endocrinol · 2026
  2. 02
    Mechanistic insights into aging and longevity: Implications for ovarian function and health
    Harrath AH · Tissue Cell · 2026
  3. 03
    Metformin improves cardiac stress tolerance and mitochondrial function during early aging
    Chen Q, Thompson J, Hu Y et al. · Exp Gerontol · 2026
  4. 04
    Metformin reduces senescence induced by obesity-related inflammation in luminal breast cancer through estrogen receptor beta modulation
    Morla-Barcelo PM, Melguizo-Salom L, Martinez-Bernabe T et al. · Biochem Pharmacol · 2026
  5. 05
    Metformin attenuates lens epithelial cell senescence by suppressing cGAS-STING via SIRT1-PGC-1α-mediated mitochondrial fission
    Luo J, Wei C, Sun L et al. · Exp Gerontol · 2026
  6. 06
    Metformin-induced longevity is associated with retrotransposon dynamics in yeast chronological aging
    Meneses-Plascencia J, Moreno-Méndez E, Ascencio D et al. · Mech Ageing Dev · 2026
  7. 07
    Computational exploration of squalene analog 4,4'diapophytofluene as a potential anti-aging phytotherapeutic
    Dutta M, Hazra A, Mandal Biswas S · Comput Biol Chem · 2026
  8. 08
    Zinc and metformin co-functionalized polyetheretherketone: A novel dental implant material tailored for the elderly
    Liu Z, Zhao E, Wang Y et al. · J Adv Res · 2026
  9. 09
    Metformin Attenuates Ciliary Muscle Aging by Downregulating GSK-3β to Modulate Cell-Cycle Progression and Autophagy
    Wu J, Wen Y, Cao H et al. · FASEB J · 2026
  10. 10
    Mechanisms of Anti-Aging Effect of Alpinia oxyphylla Polysaccharides Mediated via IIS Pathway: Based on In Vivo Experiments, Network Pharmacology and Molecular Docking
    Chen T, Wang Y, Wu Y et al. · Molecules · 2026
  11. 11
    Metformin beyond Glycemic Control: New Mechanistic Insights and Expanding Therapeutic Horizons
    Han E, Nam JH, Lee I et al. · Diabetes Metab J · 2026
  12. 12
    Beyond disease treatment and prevention: From geroscience and molecular hallmarks to gerotherapeutics and precision geromedicine
    Peng LN, Hsiao FY, Chen LK · J Chin Med Assoc · 2026
  13. 13
    Autophagy related 7 dysfunction in senescent melanocytes and hypopigmented skin: reversal by metformin
    Kim JC, Park TJ, Kim Y et al. · Br J Dermatol · 2026
  14. 14
    Metformin promotes healthspan by attenuating frailty and preserving musculoskeletal function-structure in middle-aged mice
    Morales-Carrizales DA, Garza-Guzman D, Loera-Arias MJ et al. · Biogerontology · 2026
  15. 15
    Metformin and butyrate attenuate chronic radiation proctitis by alleviating inflammation and macrophage senescence
    Chi MS, Jen HI, Ho SY et al. · Front Immunol · 2026
  16. 16
    High Glucose Triggers Macrophage Senescence Through Mitochondrial Dysfunction and Mitophagy Impairment
    Tang L, Huang X, Li P · Cell Biochem Funct · 2026
  17. 17
    Exercise in a Pill: Emerging Therapeutics for Age-Related Orthopedic Diseases
    Luo J, Meng X, Han J et al. · Antioxid Redox Signal · 2026
  18. 18
    Exploring the impact of metformin on testicular aging in Syrian hamsters
    Cavallotti Gomez A, Rossi SP, Munduruca Pires T et al. · Geroscience · 2026
  19. 19
    Pioneers: Glucose Sensing and Control of Health-span and Lifespan
    Lin SC · J Mol Biol · 2026
  20. 20
    Senescence-regulating agents remodel mesenchymal stem cell-schwann cell circuitry for diabetic bone regeneration
    Lao A, Sun Y, Li W et al. · Biomaterials · 2026
  21. 21
    No evidence for squaring the survival curve: lifespan-extending treatments increase variation in age- at-death
    Fulton TL, Macartney EL, Senior AM · Biol Lett · 2026
  22. 22
    Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth-Associated Proteins
    Delhaes F, Falciola J, Hoffman A et al. · Aging Cell · 2026
  23. 23
    Metformin inhibits nuclear egress of chromatin fragments in senescence and aging
    Kumazawa T, Xu Y, Wang Y et al. · Nat Aging · 2026
  24. 24
    Metformin Attenuates ox-LDL-Induced Macrophage Senescence and Inflammation via NR4A1-Mediated Mitophagy Regulation
    Li L, Huang X, Li P · Basic Clin Pharmacol Toxicol · 2026
  25. 25
    Oxidative Stress and SIRT1-Nrf2 Anti-Ferroptotic Pathways in Granulosa Cells: A Molecular Key to Follicular Atresia and Ovarian Aging
    Voros C, Chatzinikolaou F, Papadimas G et al. · Int J Mol Sci · 2026