Evidence base

Studies on N-Acetylcysteine (NAC)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

21,181 studies total·Last updated: June 4, 2026Open on PubMed

Longevity & aging · 289

Open on PubMed
  1. 01
    Lack of receptor for advanced glycation end products attenuates obesity-induced adipose tissue senescence in mice
    Du Z, Wu J, Zhang T et al. · Adipocyte · 2026
  2. 02
    Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits
    Kurtz JA, Singleton KM, Vasenina E et al. · Curr Nutr Rep · 2026
  3. 03
    Ambient NO(2) induces premature pulmonary senescence in rats: The role of the ROS-DRG1/CDK5 axis
    Ye S, Luo S, Tan Y et al. · J Environ Sci (China) · 2026
  4. 04
    Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
    Sahu AK, Minetti A, Di Fraia D et al. · Nat Commun · 2026
  5. 05
    High Glucose Triggers Macrophage Senescence Through Mitochondrial Dysfunction and Mitophagy Impairment
    Tang L, Huang X, Li P · Cell Biochem Funct · 2026
  6. 06
    Tryptophan metabolites 3-hydroxykynurenine (3HK) and 3-hydroxyanthranilic acid (3HAA) increase oxidative stress and impair osteoblastic bone formation
    Alhamad DW, Bensreti H, Ding K et al. · J Biol Chem · 2026
  7. 07
    Intrarenal renin-angiotensin system inactivation ameliorates tubulopathy via attenuation of mitochondrial oxidative stress, dysfunction and senescence in diabetes
    Yang WX, Pang YC, Liao MC et al. · Clin Sci (Lond) · 2026
  8. 08
    [Danggui Buxue Decoction delays vascular endothelial cell senescence induced by intermittent hypoxia through regulating Nrf2]
    Chen J, Zhang H, Guo YJ et al. · Zhongguo Zhong Yao Za Zhi · 2026
  9. 09
    ROS-mediated senescence and autophagy inhibition drive 5-FU/Aumolertinib synergy in colorectal cancer
    Liu P, Wu X, Jiang Z et al. · Eur J Pharmacol · 2026
  10. 10
    Progress in anti-ageing drug research for age-related diseases: A review
    Zhou ZY, Duan HT, Xue ST et al. · Ageing Res Rev · 2026
  11. 11
    MAVS/CMTM6 axis couples mitochondrial homeostasis to immunogenic senescence via CCL3-driven T-cell recruitment in renal carcinoma
    Wang H, Fan Y, Liang Q et al. · J Immunother Cancer · 2025
  12. 12
    Active Vitamin D Insufficiency Accelerates Skeletal Aging via Oxidative Stress and p16-Mediated Senescence
    Qiao W, Huang M, Chen L et al. · Front Biosci (Landmark Ed) · 2025
  13. 13
    N-acetyl-l-cysteine ethyl ester (NACET) induces the transcription factor NRF2 and prevents retinal aging and diabetic retinopathy
    Realini G, Amato R, Rasa M et al. · Redox Biol · 2025
  14. 14
    Urolithin Α modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing
    Roussos A, Kitopoulou K, Borbolis F et al. · Autophagy · 2025
  15. 15
    N-Homocysteinylation of HMGB1/2 Promotes Corpus Cavernosum Endothelial Senescence in Erectile Dysfunction
    Hu P, Fu S, Li B et al. · Int J Biol Sci · 2025
  16. 16
    Selective Senolysis of 5FU-Induced CRC Senescent Cells by Piceatannol Through Mitochondrial Depolarization and AIF-Dependent Apoptosis
    Ambrosino A, Patrone D, Moriello C et al. · Int J Mol Sci · 2025
  17. 17
    Age-Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function
    Sonar SA, Bhat R, Thompson HL et al. · Aging Cell · 2025
  18. 18
    Senkyunolide I prevent chondrocytes from oxidative stress through Nrf2/HO-1 signaling pathway
    Li P, Tang W, Wen H et al. · Naunyn Schmiedebergs Arch Pharmacol · 2025
  19. 19
    Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial
    Rastgoo S, Pourvali K, Raeissadat SA et al. · Front Immunol · 2025RCT
  20. 20
    Liver quad culture chip as a model for radiation injury research
    Ueda Y, Omiya S, Pinney J et al. · Sci Rep · 2025
  21. 21
    Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet
    Ommi NB, Mattocks DAL, Kalecký K et al. · Aging (Albany NY) · 2025
  22. 22
    Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals
    Xu Y, You J, Yao J et al. · Urolithiasis · 2025
  23. 23
    Topical Instillation of N-Acetylcysteine and N-Acetylcysteine Amide Impedes Age-Related Lens Opacity in Mice
    Ishida H, Sasaki Y, Shibata T et al. · Biomolecules · 2025
  24. 24
    Aging Favors Calcium Activation of Ryanodine Receptor Channels from Brain Cortices and Hippocampi and Hinders Learning and Memory in Male Rats
    More J, Finkelstein JP, Valdés JL et al. · Int J Mol Sci · 2025
  25. 25
    The impact of cysteine on lifespan in three model organisms: A systematic review and meta-analysis
    Ma Y, Chen M, Huang K et al. · Aging Cell · 2025SR

Immune system · 1,423

Open on PubMed
  1. 01
    SiO₂ exposure triggers NOX1/ROS-dependent epithelial necroptosis and drives Th17 cell activation to initiate pneumonia in mice
    Zhang P, Liu C · Int Immunopharmacol · 2026
  2. 02
    Cytochrome P450 1B1 directs pathogenic Th17 cell generation and autoimmune disease by fine-tuning redox homeostasis and mitochondrial integrity
    Hu W, Sun Y, Sun J et al. · Proc Natl Acad Sci U S A · 2026
  3. 03
    High Glucose Triggers Macrophage Senescence Through Mitochondrial Dysfunction and Mitophagy Impairment
    Tang L, Huang X, Li P · Cell Biochem Funct · 2026
  4. 04
    Sterol Endoperoxides and Their Antileishmanial Effects: Influence on Viability, Oxygen Metabolism and Sterol Synthesis
    Sarkar D, Aleta A, Ahmetašević M et al. · Molecules · 2026
  5. 05
    Hyperthermia induces reductive stress in murine macrophages
    Xu R, Liang XW, Cai QH et al. · Biochim Biophys Acta Mol Basis Dis · 2026
  6. 06
    A First-Aid Nanomedicine Endowed with Microenvironment Self-Adaptive Regulation Ability to Facilitate Acute Liver Failure Prophylaxis and Therapy
    Zhang J, Yan M, Tang Y et al. · ACS Nano · 2026
  7. 07
    LL37-induced mitochondrial stress activates the mtDNA/cGAS/STING pathway to promote mast cell-mediated rosacea inflammation
    Sun R, Fan H, Ma Q et al. · Free Radic Biol Med · 2026
  8. 08
    Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation
    Vasamsetti SB, Sadaf S, Uddin MA et al. · Nat Commun · 2026
  9. 09
    Boswellia serrata Extract and Its Bioactive Compound 3-O-Acetyl-11-Keto-β-Boswellic Acid (AKBA) Induce ROS-Mediated Intracellular Clearance of Porphyromonas gingivalis in Human Gingival Epithelial Cells
    Vang D, Carneiro PH, Henao L et al. · Int J Mol Sci · 2026
  10. 10
    Dietary titanium dioxide particles (E171) promote colitis-associated colorectal cancer development in mice through macrophage-derived S100A8/S100A9secretion mediated by NLRP3/Caspase 1/GSDMD pathway
    Wang P, Zhong Y, Liu J et al. · Chin J Nat Med · 2026
  11. 11
    Synergistic regulation of TGF-β1/Smad2/3 signaling and inflammatory pathways via SA/NAC-based nanoplatforms: a novel strategy to enhance anti-fibrotic therapeutic outcomes in idiopathic pulmonary fibrosis
    Li C, Yuan Y, Bao Y et al. · J Nanobiotechnology · 2026
  12. 12
    NAC and DNase I synergistically reduce NETs to attenuate severe acute pancreatitis via suppressing the NETs/NF-κB/CXCL3 pathway
    Li B, Liu P, Yang X et al. · Apoptosis · 2026
  13. 13
    A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities
    Gao W, Lin Z, Bao Y et al. · Front Immunol · 2025
  14. 14
    Antioxidant N-Acetylcysteine Facilitates Breast Cancer Metas-Tasis via Immunosuppressive Reprogramming of Neutrophils
    Zhang J, Wang D, Wang H et al. · Int J Mol Sci · 2026
  15. 15
    Tannin-Mediated Ischemia-Homing-Angiogenesis Nanodots (IHAND) for Synergistic Angiogenesis and Heart Failure Prevention Post-Myocardial Infarction
    Gong X, Wang S, Zhang J et al. · Adv Mater · 2026
  16. 16
    Characterization of engineered stone dust-induced reactive oxygen species generation and cytotoxicity in vitro
    Mandler WK, Knepp AK, Leonard SS et al. · J Toxicol Environ Health A · 2026
  17. 17
    Macrophage extracellular traps promote peritoneal fibrosis through the ROS/TGF-β/Smad pathway under high-glucose dialysis conditions
    Wang J, Yu C, Lyu H et al. · Int Immunopharmacol · 2025
  18. 18
    Depletion of myeloid cells in AG129 mice reduces the infection-mediated oxidative stress and restrains dengue virus-induced thymic atrophy
    Kusuma B, Rawat S, Saha O et al. · Cell Commun Signal · 2025
  19. 19
    Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation
    Kuttikrishnan S, Mariyam Z, Ahmad F et al. · Eur J Pharmacol · 2025
  20. 20
    Synergistic elimination of bacillus Calmette-Guérin biofilm and tissue restoration facilitated by ultrasound-mediated nanoparticles and antioxidants
    Zhang Y, Huang C, Qiu Y et al. · Int Immunopharmacol · 2025
  21. 21
    Elevated cellular accumulation of endogenous and exogenous CoQ by altered intracellular trafficking
    Wang Y, Hekimi S · J Biol Chem · 2025
  22. 22
    Corticosteroid insensitivity in asthma associated with obstructive sleep apnoea: Role of oxidative stress and histone acetylation
    Lo CY, Wang CH, Lin CY et al. · Br J Pharmacol · 2025
  23. 23
    Biochemical Modifications of Homocysteine Drive Neutrophil Extracellular Trap Formation in Ischemic Stroke
    Nair AS, Thimmappa PY, Jasti DB et al. · FASEB J · 2025
  24. 24
    Fructose intake driven glycolysis-ROS-EGFR axis specifically promotes the generation and pathogenicity of Th17 cells
    Liu X, Hu W, Sun J et al. · Nat Commun · 2025
  25. 25
    Quercetin Confers Protection against Sepsis-Related Acute Respiratory Distress Syndrome by Suppressing ROS/p38 MAPK Pathway
    Ding WC, Chen J, Li Q et al. · Chin J Integr Med · 2025

Metabolic health · 446

Open on PubMed
  1. 01
    Morphological and Biochemical Insights Into the Renoprotective Effects of Combined N-Acetylcysteine and Glycine Treatment in Experimental Diabetic Nephropathy
    Ejubović M, Belančić A, Lam YW et al. · Pharmacol Res Perspect · 2026
  2. 02
    1,25-Dihydroxyvitamin D3 mitigates high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in glomerular mesangial cells via the ROS/TXNIP/NLRP3 pathway
    Meng Q, Chen B, Zhang C et al. · Histol Histopathol · 2026
  3. 03
    Maternal Immune Activation Disrupts Autophagy and Glucose Homeostasis: Experimental Evidence for the Protective Effects of N-Acetylcysteine on Maternal and Offspring Outcomes in a Rat Model
    Afşar E, Öz M, Özkan E et al. · J Appl Toxicol · 2026
  4. 04
    Intrarenal renin-angiotensin system inactivation ameliorates tubulopathy via attenuation of mitochondrial oxidative stress, dysfunction and senescence in diabetes
    Yang WX, Pang YC, Liao MC et al. · Clin Sci (Lond) · 2026
  5. 05
    Molecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic mice
    Kamimura N, Iuchi K, Igarashi T et al. · J Nutr Biochem · 2026
  6. 06
    Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation
    Vasamsetti SB, Sadaf S, Uddin MA et al. · Nat Commun · 2026
  7. 07
    Berberine and N-Acetylcysteine ameliorate diabetes-induced hippocampal damage by inhibiting apoptosis and neuroinflammation, and improve synaptic plasticity in rats
    Altındağ F, İgit T · J Mol Histol · 2026
  8. 08
    Antioxidants improve the viability of diabetic bone marrow MSCs without rescuing their pro-regenerative secretome function
    Maartens M, Vlok M, van de Vyver M · Mol Cell Endocrinol · 2025
  9. 09
    N-acetylcysteine therapy reduces major adverse cardiovascular events in patients with type 2 diabetes mellitus
    Sun M, Lu Z, Chen WM et al. · Atherosclerosis · 2025
  10. 10
    CXCL12 as a Potential Hub Gene for N-Acetylcysteine Treatment of T1DM Liver Disease
    Zhao M, Han M, Guo S et al. · Biomolecules · 2025
  11. 11
    Ginsenoside Rg2 Alleviates HFD/STZ-Induced Diabetic Nephropathy by Inhibiting Pyroptosis via NF-κB/NLRP3 Signaling Pathways
    Li K, Wang YJ, Wei K et al. · Am J Chin Med · 2025
  12. 12
    Advanced Glycation End Products and Skin Autoimmune Disorders: Pathogenic Insights into Vitiligo, Bullous Pemphigoid, and Type 1 Diabetes Mellitus
    Bjørklund G, Gurgas L, Hangan T · Curr Med Chem · 2025
  13. 13
    N-Acetylcysteine enhances low-dose estrogen efficacy against ischemia-reperfusion injury in estrogen-deprived obese insulin-resistant rats
    Sivasinprasasn S, Chattipakorn K, Pratchayasakul W et al. · Menopause · 2025
  14. 14
    The role of FOXM1 in acetylcysteine improving diabetic periodontitis
    Yang Y, Ren D, Peng B et al. · J Mol Histol · 2024
  15. 15
    20(R)-ginsenoside Rg3 alleviates diabetic retinal injury in T2DM mice by attenuating ROS-mediated ER stress through the activation of the Nrf2/HO-1 axis
    Li WL, Li K, Chang WG et al. · Phytomedicine · 2024
  16. 16
    Drug conjugates crosslinked bioresponsive hydrogel for combination therapy of diabetic wound
    Zheng M, Song W, Huang P et al. · J Control Release · 2024
  17. 17
    Neuregulin 4 Downregulation Alters Mitochondrial Morphology and Induces Oxidative Stress in 3T3-L1 Adipocytes
    Díaz-Sáez F, Balcells C, Rosselló L et al. · Int J Mol Sci · 2024
  18. 18
    N-acetylcysteine supplementation improves endocrine-metabolism profiles and ovulation induction efficacy in polycystic ovary syndrome
    Fang YQ, Ding H, Li T et al. · J Ovarian Res · 2024RCT
  19. 19
    Cadmium exposure induces skeletal muscle insulin resistance through the reactive oxygen species-mediated PINK1/Parkin pathway
    Chen C, Chen Y, Zhai H et al. · Ecotoxicol Environ Saf · 2024
  20. 20
    N-acetylcysteine combined with insulin therapy can reduce myocardial injury induced by type 1 diabetes through the endoplasmic reticulum pathway
    Wu H, Huo H, Li H et al. · Tissue Cell · 2024
  21. 21
    The Influence of N-Acetylcysteine-Enriched Hydrogels on Wound Healing in a Murine Model of Type II Diabetes Mellitus
    Stachura A, Sobczak M, Kędra K et al. · Int J Mol Sci · 2024
  22. 22
    Insulin combined with N-acetylcysteine attenuates type 1 diabetes-induced splenic inflammatory injury in canines by inhibiting the MAPKs-NF-κB signaling pathway and pyroptosis
    Zhang X, Qiu W, Huang J et al. · J Diabetes Complications · 2024
  23. 23
    Effect of N-acetyl cysteine in children with metabolic dysfunction-associated steatotic liver disease-A pilot study
    Babu Balagopal P, Kohli R, Uppal V et al. · J Pediatr Gastroenterol Nutr · 2024RCT
  24. 24
    Activation of the ROS/TXNIP/NLRP3 pathway disrupts insulin-dependent glucose uptake in skeletal muscle of insulin-resistant obese mice
    Russell-Guzmán J, Américo-Da Silva L, Cadagan C et al. · Free Radic Biol Med · 2024
  25. 25
    Mitigation of ROS-triggered endoplasmic reticulum stress by upregulating Nrf2 retards diabetic nephropathy
    Zeng X, Zhang Y, Tian L et al. · Biochem Biophys Res Commun · 2024