Studies on Nattokinase

1. 01
   Nattokinase Attenuates Acute Cerebral Infarction in a Rat Model of Middle Cerebral Artery Occlusion

   Tanikawa T, Yu J, Hsu K et al. · In Vivo · 2026
2. 02
   Investigation of the synergistic effect of enzymatic and Ultrasound-Induced amyloid microclot degradation

   Rasouli R, Hartl B, D Konecky S · J Thromb Thrombolysis · 2026
3. 03
   Nattokinase supplementation for cognitive enhancement in asymptomatic intracranial/carotid stenosis: A randomized controlled trial

   Zhang K, Zhang X, Wang A et al. · J Stroke Cerebrovasc Dis · 2026RCT
4. 04
   Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks

   Dobre MZ, Virgolici B, Doicin IC et al. · Int J Mol Sci · 2025
5. 05
   Ameliorated effects of nattokinase on high-fat diet and carrageenan-induced tail-thrombosis mice

   Chen X, Cao G, Meng F et al. · J Sci Food Agric · 2025
6. 06
   A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation

   Shi Y, Liu C, Gui Y et al. · Adv Healthc Mater · 2025
7. 07
   Nattokinase's Neuroprotective Mechanisms in Ischemic Stroke: Targeting Inflammation, Oxidative Stress, and Coagulation

   Yang XY, Wang SL, Xue WC et al. · Antioxid Redox Signal · 2025
8. 08
   Nattokinase Attenuated Excitatory Amino Acids and Cytokines Release and Restored Cerebral Blood Flow in a Thrombolytic Focal Cerebral Ischemic Rat Model

   Ramanathan M, Kayal Madathil MJ, Jose JM et al. · Cent Nerv Syst Agents Med Chem · 2025
9. 09
   Dual Frequency-Regulated Magnetic Vortex Nanorobots Empower Nattokinase for Focalized Microvascular Thrombolysis

   Gao R, Zhang W, Chen X et al. · ACS Nano · 2024
10. 10
    Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis

    Wang D, Kou Y, Guo T et al. · Life Sci · 2024
11. 11
    Nattokinase as an adjuvant therapeutic strategy for non-communicable diseases: a review of fibrinolytic, antithrombotic, anti-inflammatory, and antioxidant effects

    Granito M, Alvarenga L, Ribeiro M et al. · Expert Rev Cardiovasc Ther · 2024
12. 12
    Comparative Cardioprotective Effectiveness: NOACs vs. Nattokinase-Bridging Basic Research to Clinical Findings

    Muric M, Nikolic M, Todorovic A et al. · Biomolecules · 2024
13. 13
    Significance of Soy-Based Fermented Food and Their Bioactive Compounds Against Obesity, Diabetes, and Cardiovascular Diseases

    Dwivedi S, Singh V, Sharma K et al. · Plant Foods Hum Nutr · 2024
14. 14
    ROS-responsive phenylboronic ester-based nanovesicles as multifunctional drug delivery systems for the treatment of inflammatory and thrombotic complications

    Xia Y, Chen R, Ke Y et al. · Biomater Sci · 2023
15. 15
    Study on the transport and internalisation mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models

    Feng H, Liu C, Liu Q et al. · Xenobiotica · 2023
16. 16
    Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy

    Huang Z, Chu WK, Ng TK et al. · J Diabetes · 2023
17. 17
    Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin

    Wu H, Zhang Q, Xu P et al. · J Agric Food Chem · 2023
18. 18
    Microbial nattokinase: from synthesis to potential application

    Sheng Y, Yang J, Wang C et al. · Food Funct · 2023
19. 19
    Heterologous expression of recombinant nattokinase in Escherichia coli BL21(DE3) and media optimization for overproduction of nattokinase using RSM

    Modi A, Raval I, Doshi P et al. · Protein Expr Purif · 2023
20. 20
    Stepwise Strategy to Identify Thrombin as a Hydrolytic Substrate for Nattokinase

    Wang Y, Wang H, Zhang Y et al. · J Chem Inf Model · 2022
21. 21
    Fibrinolytic Enzyme - An Overview

    Abdul Rahim P, Rengaswamy D · Curr Pharm Biotechnol · 2022
22. 22
    Data Recorded in Real Life Support the Safety of Nattokinase in Patients with Vascular Diseases

    Gallelli G, Di Mizio G, Palleria C et al. · Nutrients · 2021
23. 23
    Synthesis of sustained release/controlled release nanoparticles carrying nattokinase and their application in thrombolysis

    Liu S, Zhu J, Liu C et al. · Pharmazie · 2021
24. 24
    Expression of a novel dual-functional polypeptide and its pharmacological action research

    Li X, Yang X, Umar M et al. · Life Sci · 2021
25. 25
    Nattokinase atherothrombotic prevention study: A randomized controlled trial

    Hodis HN, Mack WJ, Meiselman HJ et al. · Clin Hemorheol Microcirc · 2021RCT

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