Evidence base

Studies on Rhodiola Rosea

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

2,226 studies total·Last updated: May 27, 2026Open on PubMed

Stress & anxiety · 33

Open on PubMed
  1. 01
    Network pharmacological analysis and animal experiment verification of SAL inhibiting the IL-17 signaling pathway in the treatment of depression
    Li RX, Wang RZ, Tian JY et al. · Int Immunopharmacol · 2026
  2. 02
    Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes
    Łuszczak J, Kocki J · Ann Agric Environ Med · 2026SR
  3. 03
    Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study
    McKinney E, Stewart J, Kewalramani R et al. · Trials · 2026RCT
  4. 04
    Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce
    Sarris J, Ravindran A, Yatham LN et al. · World J Biol Psychiatry · 2022Meta
  5. 05
    The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence
    Ivanova Stojcheva E, Quintela JC · Molecules · 2022
  6. 06
    [Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea]
    Yu HL, Zhang PP, Zhang C et al. · Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · 2019RCT
  7. 07
    Puerariae Radix Prevents Anxiety and Cognitive Deficits in Mice Under Oligomeric Aβ-Induced Stress
    Huang HJ, Huang CY, Lee M et al. · Am J Chin Med · 2019
  8. 08
    Burnout: A Multicenter Exploratory Clinical Trial With a Proprietary Extract of Rhodiola rosea in Patients With Burnout Syndrome
    Ross SM · Holist Nurs Pract · 2018
  9. 09
    Antidepressant-like effect of salidroside and curcumin on the immunoreactivity of rats subjected to a chronic mild stress model
    Vasileva LV, Saracheva KE, Ivanovska MV et al. · Food Chem Toxicol · 2018
  10. 10
    Stress management and the role of Rhodiola rosea: a review
    Anghelescu IG, Edwards D, Seifritz E et al. · Int J Psychiatry Clin Pract · 2018
  11. 11
    Beneficial Effect of Chronic Treatment with Extracts from Rhodiola Rosea L. and Curcuma Longa L. on the Immunoreactivity of Animals Subjected to a Chronic Mild Stress Model
    Vasileva LV, Saracheva KЕ, Ivanovska MV et al. · Folia Med (Plovdiv) · 2017
  12. 12
    Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator
    Gerbarg PL, Brown RP · Phytomedicine · 2016
  13. 13
    The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms
    Cropley M, Banks AP, Boyle J · Phytother Res · 2015RCT
  14. 14
    [Rhodiola rosea special extract: Arctic forces against stress]
    Schönfelder Y · MMW Fortschr Med · 2015
  15. 15
    Rhodiola rosea (SHR-5), Part I: a proprietary root extract of Rhodiola rosea is found to be effective in the treatment of stress-related fatigue
    Ross SM · Holist Nurs Pract · 2014RCT
  16. 16
    Characterization of the anxiolytic activity of Nunavik Rhodiola rosea
    Cayer C, Ahmed F, Filion V et al. · Planta Med · 2013
  17. 17
    Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study
    Edwards D, Heufelder A, Zimmermann A · Phytother Res · 2012
  18. 18
    Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence
    Sarris J, Panossian A, Schweitzer I et al. · Eur Neuropsychopharmacol · 2011SR
  19. 19
    Evaluation of Rhodiola rosea L. extract on affective and physical signs of nicotine withdrawal in mice
    Mattioli L, Perfumi M · J Psychopharmacol · 2011
  20. 20
    Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating
    Cifani C, Micioni Di Bonaventura MV, Vitale G et al. · Physiol Behav · 2010
  21. 21
    Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions
    Aslanyan G, Amroyan E, Gabrielyan E et al. · Phytomedicine · 2010RCT
  22. 22
    Anti-oxidative effect of Rhodiola imbricata root extract in rats during cold, hypoxia and restraint (C-H-R) exposure and post-stress recovery
    Gupta V, Lahiri SS, Sultana S et al. · Food Chem Toxicol · 2010
  23. 23
    The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment
    Schutgens FW, Neogi P, van Wijk EP et al. · Phytother Res · 2009RCT
  24. 24
    Mechanism of action of Rhodiola imbricata Edgew during exposure to cold, hypoxia and restraint (C-H-R) stress induced hypothermia and post stress recovery in rats
    Gupta V, Lahiri SS, Sultana S et al. · Food Chem Toxicol · 2009
  25. 25
    [Salidroside protects the hypothalamic-pituitary-gonad axis of male rats undergoing negative psychological stress in experimental navigation and intensive exercise]
    Wang Q, Wang J, Sun LJ et al. · Zhonghua Nan Ke Xue · 2009

Cognition · 37

Open on PubMed
  1. 01
    Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study
    Koozehchian MS, Newton AT, Mabrey G et al. · Nutrients · 2025RCT
  2. 02
    Salidroside Attenuates Epilepsy and Cognitive Dysfunction in Rats by Downregulating Complement C3-C3aR Pathway-Mediated Activation of Microglia and Astrocytes
    Huang M, Tang M, Liu L · Neurochem Res · 2025
  3. 03
    Protective effects of Salidroside against ferroptosis through PPARG-dependent mechanism in diabetes-related cognitive impairment
    Yu S, Liu W · Exp Neurol · 2025
  4. 04
    Salidroside improves blood-brain barrier integrity and cognitive function in hypobaric hypoxia mice by inhibiting microglia activation through GSK3β
    Zhang X, Zhang H, Liu Z et al. · Phytother Res · 2025
  5. 05
    Immediate and residual effects of functional chewing gum on sustained attention and mood
    Haworth E, Haskell-Ramsay CF · Nutr Neurosci · 2025RCT
  6. 06
    Salidroside attenuates cognitive deficits induced by chronic cerebral hypoperfusion via modulating microglial phenotypic transformation in mice
    Ji W, Zhang Z, Jin T et al. · J Neuroimmunol · 2025
  7. 07
    Xinnaoxin capsule alleviates neuropathological changes and cognitive deficits in Alzheimer's disease mouse model induced by D-galactose and aluminum chloride via reducing neuroinflammation and protecting synaptic proteins
    Wu X, Qiu X, Wang S et al. · J Ethnopharmacol · 2025
  8. 08
    [Targets and Molecular Mechanisms of Salidroside in Improving High-Altitude Cognitive Function]
    Sun Y, Qin N, Ji Q et al. · Sichuan Da Xue Xue Bao Yi Xue Ban · 2025
  9. 09
    The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside
    Niu L, Xu M, Liu W et al. · J Mol Histol · 2024
  10. 10
    Salidroside improves cognitive function in Parkinson's disease via Braf-mediated mitogen‑activated protein kinase signaling pathway
    Lu S, Ji N, Wang W et al. · Biomed Pharmacother · 2024
  11. 11
    Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on Ginkgo biloba and Rhodiola rosea
    Mueller JK, Müller WE · J Neural Transm (Vienna) · 2024
  12. 12
    Botanical Mixture Containing Nitric Oxide Metabolite Enhances Neural Plasticity to Improve Cognitive Impairment in a Vascular Dementia Rat Model
    Zhang X, Yang SB, Cheng L et al. · Nutrients · 2023
  13. 13
    Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice
    Yang S, Wang L, Zeng Y et al. · Phytomedicine · 2023
  14. 14
    Salidroside attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in septic encephalopathy mice
    Xiao L, Li L, Huang J et al. · Int Immunopharmacol · 2023
  15. 15
    Salidroside Alleviates Diabetic Cognitive Dysfunction Via B3galt2/F3/Contactin Signaling Pathway in Mice
    Lv P, Zuo Z, Liu W et al. · Neuroscience · 2023
  16. 16
    Rosiridin Attenuates Scopolamine-Induced Cognitive Impairments in Rats via Inhibition of Oxidative and Nitrative Stress Leaded Caspase-3/9 and TNF-α Signaling Pathways
    Afzal M, Alzarea SI, Alharbi KS et al. · Molecules · 2022
  17. 17
    Salidroside ameliorates orthopedic surgery-induced cognitive dysfunction by activating adenosine 5'-monophosphate-activated protein kinase signaling in mice
    Pan CL, Dai GL, Zhang HW et al. · Eur J Pharmacol · 2022
  18. 18
    The Influence of Tyrosol-Enriched Rhodiola sachalinensis Extracts Bioconverted by the Mycelium of Bovista plumbe on Scopolamine-Induced Cognitive, Behavioral, and Physiological Responses in Mice
    Kwon MJ, Lee JW, Kim KS et al. · Molecules · 2022
  19. 19
    Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review
    Crawford C, Boyd C, Deuster PA · J Altern Complement Med · 2021SR
  20. 20
    Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study
    Koop T, Dienel A, Heldmann M et al. · Phytother Res · 2020
  21. 21
    Neuroprotective Effects of Salidroside in a Mouse Model of Alzheimer's Disease
    Wang H, Li Q, Sun S et al. · Cell Mol Neurobiol · 2020
  22. 22
    Therapeutic Effects of Salidroside on Cognitive Ability in Rats with Experimental Vascular Dementia
    Tian Z, Li Y, Wang G et al. · Bull Exp Biol Med · 2020
  23. 23
    Neuroprotective effect of salidroside against central nervous system inflammation-induced cognitive deficits: A pivotal role of sirtuin 1-dependent Nrf-2/HO-1/NF-κB pathway
    Xu N, Huang F, Jian C et al. · Phytother Res · 2019
  24. 24
    Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment - Transcriptome-wide microarray profiles of neuroglia cells
    Seo EJ, Klauck SM, Efferth T et al. · Phytomedicine · 2019
  25. 25
    Puerariae Radix Prevents Anxiety and Cognitive Deficits in Mice Under Oligomeric Aβ-Induced Stress
    Huang HJ, Huang CY, Lee M et al. · Am J Chin Med · 2019

Energy & endurance · 114

Open on PubMed
  1. 01
    Rapid Lipidomics Analysis of Oxidised Phosphatidylcholines in Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice and Their Regulation by Rhodiola crenulata Oligomeric Proanthocyanidins
    Mwangi CN, Jia L, Zhang Q et al. · Rapid Commun Mass Spectrom · 2026
  2. 02
    Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial
    Dou Y, Wang Y, Zhang W et al. · Nutrients · 2026RCT
  3. 03
    Rational Construction of a Lipid Droplet-Targeted Redox-Responsive Ratiometric Probe for Screening of Antioxidant Drugs and Its Application in Parkinson's Disease
    Deng M, Zhai Z, Zhang H et al. · Anal Chem · 2026
  4. 04
    Natural Products for Alzheimer's Disease: A New Twist Impacting Ferroptosis
    Yi Y, Jia P, Xie P et al. · Am J Chin Med · 2026
  5. 05
    Salidroside mitigates Oligoasthenospermia by attenuating ferroptosis via NF-κB pathway inhibition
    Zhao X, Zhang K, Lei X et al. · Phytomedicine · 2026
  6. 06
    Effects of salidroside on structural and functional properties of myofibrillar proteins in the Fenton system
    Duan J, Zhao Q, Li C et al. · Meat Sci · 2026
  7. 07
    The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players
    Wang J, Zhao H, Yu L et al. · Nutrients · 2025RCT
  8. 08
    Salidroside Promotes Fatty Acid β-Oxidation and Reduces Hepatic Lipid Deposition in Largemouth Bass by Activating Autophagy via the AMPK/mTOR Pathway
    He K, Cheng L, Yang H et al. · J Agric Food Chem · 2025
  9. 09
    Salidroside Exerts Neuroprotective Effects via Inhibiting Ferroptosis in Mice with Traumatic Brain Injury
    Huang Y, He Y, Zhao X et al. · Neurochem Res · 2025
  10. 10
    The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue Conditions: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial
    Marcos-Frutos D, Leban Ž, Li Z et al. · Nutrients · 2025RCT
  11. 11
    Ginsenosides, salidroside, and syringin complex exhibits anti-fatigue in exhaustive exercise rats
    Wu YC, Lian YZ, Zhao H et al. · Int J Med Sci · 2025
  12. 12
    Salidroside exerts anti-tumor effects in ovarian cancer by inhibiting STAT3/c-Myc pathway-mediated glycolysis
    Yu G, Feng X · Biomol Biomed · 2024
  13. 13
    Salidroside and exercise performance in healthy active young adults - an exploratory, randomized, double-blind, placebo-controlled study
    Schwarz NA, Stratton MT, Colquhoun RJ et al. · J Int Soc Sports Nutr · 2024RCT
  14. 14
    Research on the Anti-Fatigue Effects and Mechanisms of Arecoline in Sleep-Deprived Mice
    Wang D, Sun Y, Liu J et al. · Nutrients · 2024
  15. 15
    Salidroside Inhibits α-Amanitin-Induced AML-12 Cell Apoptosis via the Regulation of PINK1/Parkin-Mediated Mitophagy and Mitochondrial Function
    Zhou Y, Wang J, Zhao Y et al. · Chem Res Toxicol · 2024
  16. 16
    Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance
    Kim Y, Lee WK, Jeong H et al. · Nutrients · 2024
  17. 17
    Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction
    Hou Y, Fan F, Xie N et al. · Phytomedicine · 2024
  18. 18
    Butylparaben induced zebrafish (Danio rerio) kidney injury by down-regulating the PI3K-AKT pathway
    Huang L, Xu J, Jia K et al. · J Hazard Mater · 2024
  19. 19
    Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production
    Zhang X, Zhang M, Zhang Z et al. · Exp Cell Res · 2024
  20. 20
    Synergistic Effect of Rhodiola rosea and Caffeine Supplementation on the Improvement of Muscle Strength and Muscular Endurance: A Pilot Study for Rats, Resistance Exercise-Untrained and -Trained Volunteers
    Liu C, Zhao H, Yan Y et al. · Nutrients · 2023
  21. 21
    Effects of salidroside on exercise tolerance of mice under high altitude hypoxia environment
    Qin N, Xie H, Zhao A et al. · Zhejiang Da Xue Xue Bao Yi Xue Ban · 2022
  22. 22
    Enhancement of Swimming Endurance by Herbal Supplement M3P
    Chu CM, Chi CW, Huang CH et al. · Chin J Integr Med · 2022
  23. 23
    The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence
    Ivanova Stojcheva E, Quintela JC · Molecules · 2022
  24. 24
    Salidroside attenuates CoCl(2)-simulated hypoxia injury in PC12 cells partly by mitochondrial protection
    Tang Y, Hou Y, Zeng Y et al. · Eur J Pharmacol · 2021
  25. 25
    Salidroside Induces Apoptosis in Human Gastric Cancer Cells via the Downregulation of ENO1/PKM2/GLUT1 Expression
    Dai Z, Zhang X, Li W et al. · Biol Pharm Bull · 2021