Evidence base

Studies on Vitamin B12 (Cobalamin)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

25,354 studies total·Last updated: June 4, 2026Open on PubMed

Energy & endurance · 468

Open on PubMed
  1. 01
    Associations of Plasma Homocysteine Reflecting Vitamin B(12) and Folate Status with Fatigue-Related Outcomes in Healthy Adults
    Kanouchi H, Yamamoto A, Kuwabara A et al. · Nutrients · 2026
  2. 02
    SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism
    Matmat K, Hassan Z, Pourié G et al. · Cell Rep Med · 2026
  3. 03
    Meso-fluorinated cobalamins: insights into synthesis and redox properties
    Dereven'kov IA, Osokin VS, Khodov IA · J Biol Inorg Chem · 2026
  4. 04
    Vitamin B12 Supports Skeletal Muscle Oxidative Phosphorylation Capacity in Male Mice
    Castillo LF, Heyden KE, Williamson AR et al. · J Nutr · 2026
  5. 05
    PHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW
    Morais T, Couto G, Rocha R et al. · Arq Gastroenterol · 2026
  6. 06
    Genomics and physiological characterizations of an acidotolerant nitrite-oxidizing Nitrospira enriched from freshwater pond
    Kim M, Kamagata Y, Park S-J · Appl Environ Microbiol · 2025
  7. 07
    The Responsiveness of Breast Cancer Cells to Varied Levels of Vitamin B12, Cisplatin, and G-CSF
    Aslan V, Usta DD, Yar Sağlam AS et al. · Int J Mol Sci · 2025
  8. 08
    Biomimetic Cobalt Complex Stabilized by Hydrogel on High-Edge-Density Graphite for ORR and HER in Quiescent Solutions
    Albuquerque FF, Iost RM, Fonseca GC et al. · Langmuir · 2025
  9. 09
    Plummer-Vinson syndrome in a postpolio patient: a rare intersection of neuromuscular and nutritional sequelae
    J S, John V, S SS et al. · BMJ Case Rep · 2025
  10. 10
    Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits
    Du F, Alhaskawi A, Zou X et al. · Int J Vitam Nutr Res · 2025
  11. 11
    l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduction in Blood Lactate Concentration
    de Rozas A, Pérez-Díaz JJ, Muros JJ et al. · Nutrients · 2025RCT
  12. 12
    Light-driven reductive cyclization catalyzed by vitamin B(12)-based artificial photoenzymes
    Ho TO, Goh YL, Chua W et al. · Org Biomol Chem · 2025
  13. 13
    The common homocystinuria-associated P1173L variant of human methionine synthase impairs reductive methylation
    Guha A, Banerjee R · J Biol Chem · 2025
  14. 14
    Multimode spectral-like electrochemical fingerprinting of cysteine via biomimetic electrocatalytic interface
    Qin M, Zhang Q, Yuan B et al. · Mikrochim Acta · 2025
  15. 15
    A Noncatalytic Cysteine Residue Modulates Cobalamin Reactivity in the Human B(12) Processing Enzyme CblC
    Esser AJ, Sastre S, Dinh TJ et al. · Biochemistry · 2025
  16. 16
    Characterization of PFOA isomers from PFAS precursors and their reductive defluorination
    Sun J, Lorpaiboon W, Fox N et al. · Water Res · 2025
  17. 17
    Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8(+) T cells to suppress anti-tumor immunity
    Tejero JD, Hesterberg RS, Drapela S et al. · Oncogene · 2025
  18. 18
    Electrochemical cofactor recycling of bacterial microcompartments
    Sutter M, Utschig LM, Niklas J et al. · Proc Natl Acad Sci U S A · 2024
  19. 19
    Differential utilization of vitamin B(12)-dependent and independent pathways for propionate metabolism across human cells
    Gouda H, Ji Y, Rath S et al. · J Biol Chem · 2024
  20. 20
    Mutations Affecting Cellular Levels of Cobalamin (Vitamin B(12)) Confer Tolerance to Bactericidal Antibiotics in Burkholderia cenocepacia
    Lee D, Park J, Kim HS · J Microbiol Biotechnol · 2024
  21. 21
    The radical impact of oxygen on prokaryotic evolution-enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third
    Mrnjavac N, Nagies FSP, Wimmer JLE et al. · FEBS Lett · 2024
  22. 22
    A Systematic Review of Symptoms of Pernicious Anemia
    Seage CH, Bennett A, Ward N et al. · Food Nutr Bull · 2024SR
  23. 23
    Green Molecular Transformation in Dual Catalysis: Photoredox Activation of Vitamin B(12) Using Heterogeneous Photocatalyst
    Shichijo K, Shimakoshi H · Chempluschem · 2024
  24. 24
    Potential of postbiotics for the treatment of metabolic disorders
    Mishra N, Garg A, Ashique S et al. · Drug Discov Today · 2024
  25. 25
    A singular PpaA/AerR-like protein in Rhodospirillum rubrum rules beyond the boundaries of photosynthesis in response to the intracellular redox state
    Godoy MS, de Miguel SR, Prieto MA · mSystems · 2023

Cognition · 332

Open on PubMed
  1. 01
    Microbiome functional gene pathways are indicative of cognitive performance in older adults at risk for Alzheimer's disease
    Zeamer AL, Lai Y, Loew E et al. · Gut Microbes · 2026
  2. 02
    Methionine, Homocysteine, and Methylation Levels Predict Cognitive Decline in Alzheimer's Disease
    Zhang X, Guan A, Li W et al. · CNS Neurosci Ther · 2026
  3. 03
    Acute reversible cognitive dysfunction due to vitamin B12 deficiency: A case report with rare magnetic resonance imaging findings
    Xiong Y, Wang J · J Int Med Res · 2026
  4. 04
    Serum homocysteine, hemoglobin, and Alzheimer's biomarkers involved in the relationship of folate and vitamin B12 with cognitive function: Findings from the Hubei Memory and Aging Cohort Study
    Li CX, Cheng GR, Liu XC et al. · Nutr Res · 2026
  5. 05
    Gender differences in methylcobalamin, folate, homocysteine, and hemoglobin levels among urban, community dwelling, elderly with mild cognitive impairment in a South Indian city: A cross-sectional study
    Kuchipudi JD, Menon J, Kantipudi SJ et al. · J Alzheimers Dis · 2026
  6. 06
    Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis
    Liu X, Yang C, Wang X et al. · J Prev Alzheimers Dis · 2026SR
  7. 07
    Association of lifestyle and metabolic factors with clinical performance in multiple sclerosis: A cross-sectional study
    Lerda-Casaccia T, Mitterwallner JM, Hitzl W et al. · Med Clin (Barc) · 2026
  8. 08
    Association Between Serum Methylmalonic Acid and Poor Cognitive Performance
    Wang Z, Deng Y, Chen L et al. · Am J Geriatr Psychiatry · 2026
  9. 09
    Essential micronutrients and biguanides (metformin) synergistic and antagonistic interactions on neurocognitive outcomes in type two diabetes mellitus: a systematic review of preclinical and clinical evidence
    Ninsiima HI, Ainamani HE, Ayebazibwe G et al. · Front Endocrinol (Lausanne) · 2026SR
  10. 10
    Signal-Level Determinants of Cognitive Decline With PPIs versus H(2)RAs: Transportome (CBLIF/TCN2) and CHRNA7 Nodes
    Saihati HAA, Ahmed BY, Mosaad RM et al. · Mol Nutr Food Res · 2026
  11. 11
    Association of metformin use and nutritional status with cognitive frailty in older adults with type 2 diabetes
    Ozer NT, Akin S, Akandere Barlas E · Ir J Med Sci · 2026
  12. 12
    Association between hemoglobin levels and mild cognitive impairment in generally healthy European community-dwelling older adults: a 3-year prospective analysis of the DO-HEALTH trial
    Wieczorek M, Funk J, Mattle M et al. · Am J Clin Nutr · 2026RCT
  13. 13
    Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database
    Miao J, Zhao D · Brain Behav · 2026
  14. 14
    Vitamin B12 deficiency among older adults and its associations with geriatric syndromes
    Papazachariou A, Papakitsou I, Malikides V et al. · Curr Opin Clin Nutr Metab Care · 2026
  15. 15
    Folate and vitamin B12 supplementation in patients with schizophrenia and low serum folate level: A 24-week randomized, double-blind, placebo-controlled study
    Chen CH, Chiu CC, Chiu YH et al. · J Formos Med Assoc · 2026RCT
  16. 16
    Trial protocol: DOLFIN trial: Developmental Outcomes of Long-term Feed Supplementation in Neonates-A UK multicentre, blinded, stratified, randomised controlled trial
    Andrew MJ, Embleton N, Hardy P et al. · Trials · 2025
  17. 17
    Association of MTHFR C677T and A1298C Polymorphisms in Metabolic Alterations, Neuroimaging, and Cognitive Decline in Alzheimer's Disease: Case-Control and Bioinformatics Insights
    Maurya AK, Srivastava M, Vishwakarma S et al. · Mol Neurobiol · 2025
  18. 18
    Efficacy of B Vitamin Supplementation on Global Cognitive Function in Older Adults: A Systematic Review and Meta-analysis
    Berg J, Grant R, Siervo M et al. · Nutr Rev · 2025SR
  19. 19
    A Cross-Sectional Study of the Relationship Between Dietary Micronutrient Intake, Cognition and Academic Performance Among School-Aged Children in Taabo, Côte d'Ivoire
    Tia A, Konan AG, Hauser J et al. · Nutrients · 2025
  20. 20
    Mitochondrial dysfunction-related metabolite methylmalonic acid is associated with decreased cognitive performance
    Liu Y, Wang J, Wu P et al. · PLoS One · 2025
  21. 21
    An innovative health systems approach to support early detection of cognitive impairment in primary care - the brain health navigator
    Brosch JR, Summanwar D, Fowler NR et al. · BMC Prim Care · 2025
  22. 22
    Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction
    Gordon S, Hoey L, McNulty H et al. · BMC Med · 2025
  23. 23
    Genetic Correlates of Presenile Dementia and Cognitive Decline in the Armenian Population Following COVID-19: A Case-Control Study
    Hovhannisyan Y, Yeritsyan H, Hakobjanyan G et al. · Int J Mol Sci · 2025
  24. 24
    Child plasma vitamin B12 concentrations and executive functions at age 7-11 years: the GUSTO study
    Loh J, Chan SY, Toh JY et al. · Eur J Nutr · 2025
  25. 25
    Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis
    Amanat S, Dordevic AL, Brodtmann A et al. · Adv Nutr · 2025SR

Longevity & aging · 354

Open on PubMed
  1. 01
    Decoding the complex nexus: the mechanistic interplay of hyperhomocysteinemia in brain aging and neurological disorders
    Dutta BJ, Dwivedi S, Patil VS et al. · Biogerontology · 2026
  2. 02
    Serum homocysteine, hemoglobin, and Alzheimer's biomarkers involved in the relationship of folate and vitamin B12 with cognitive function: Findings from the Hubei Memory and Aging Cohort Study
    Li CX, Cheng GR, Liu XC et al. · Nutr Res · 2026
  3. 03
    Age-Related Decline in Intestinal Villus Length: A Cross-Sectional Study on the Human Gut
    Vara-Luiz F, Palma C, Mendes I et al. · Nutrients · 2026
  4. 04
    Vitamin B12 deficiency among older adults and its associations with geriatric syndromes
    Papazachariou A, Papakitsou I, Malikides V et al. · Curr Opin Clin Nutr Metab Care · 2026
  5. 05
    Klotho, Kidneys, and Micronutrient Signaling: A Promising Paradigm for Healthy Aging
    Mahdavi S · Lifestyle Genom · 2026
  6. 06
    Vitamin B12-Loaded Chitosan Nanoparticles Promote Skeletal Muscle Injury Repair in Aged Rats via Amelioration of Aging-Suppressed Efferocytosis
    El Gazzar WB, Farag AA, Bayoumi H et al. · Biomolecules · 2025
  7. 07
    Sex-specific machine learning models for cardiovascular disease risk prediction in adults aged ≥ 80 years: insights from the Chinese longitudinal healthy longevity survey
    Jiang H, Li Y · BMC Geriatr · 2025
  8. 08
    Roles of folate, vitamin B(12) and vitamin D in older individuals with frailty
    Pratumvinit B, De Biasi J, Boonyasit Y et al. · Nutr Res Rev · 2025
  9. 09
    [Micronutrients in old age-physiological specificities and nutritional status]
    Tran HA, Weber D, Grune T · Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz · 2025
  10. 10
    Vitamin B12 modulates D-galactose-induced renal dysfunction
    Nagaraju M, Kalahasti KK, Suryavanshi U et al. · Indian J Med Res · 2025
  11. 11
    Multimicronutrient and omega-3 fatty acid supplementation reduces low-grade inflammation in older participants: An exploratory study
    Kerlikowsky F, Krüger K, Hahn A et al. · Nutr Res · 2025RCT
  12. 12
    One-carbon metabolism-related compounds are associated with epigenetic aging biomarkers: results from the cross-sectional National Health and Nutrition Examination Survey 1999-2002
    Bozack AK, Khodasevich D, Nwanaji-Enwerem JC et al. · Am J Clin Nutr · 2025
  13. 13
    Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling
    Rahman SS, Bhattacharjee S, Motwani S et al. · Nat Commun · 2025
  14. 14
    Association between methyl donor nutrients' dietary intake with phenotypic aging among US adults: a cross-sectional study from NHANES 2005-2018
    Li Y, Peng D, Yu Z et al. · Sci Rep · 2025
  15. 15
    Common occurrence of atrophic gastritis in an ageing non-hospitalised population: an autopsy study
    Karhunen P, Tuomisto S, Goebeler S et al. · Age Ageing · 2025
  16. 16
    Hyperhomocysteinemia and its effect on ageing and language functions - HEAL study
    Sandhya G, Monisha S, Singh S et al. · Sci Rep · 2024
  17. 17
    Decreased cobalamin sensitivity and biological aging acceleration in the general population
    Tang F, Qiu H, Liu Y et al. · J Nutr Health Aging · 2024
  18. 18
    Causes and Risk Factors of Vitamin B12 Deficiency at the Bookends of Life, From Infancy to Old Age
    Green R · Food Nutr Bull · 2024
  19. 19
    Vitamin B12 and Age-Related Cognitive Decline-Dementia and "Alzheimer's Disease"
    Rosenberg IH · Food Nutr Bull · 2024
  20. 20
    Aging-accumulated methylmalonic acid serum levels at breast cancer diagnosis are not associated with distant metastases
    Wu Q, Hatse S, Kenis C et al. · Breast Cancer Res Treat · 2024
  21. 21
    Emerging Roles of Vitamin B(12) in Aging and Inflammation
    Simonenko SY, Bogdanova DA, Kuldyushev NA · Int J Mol Sci · 2024
  22. 22
    Methylmalonic acid in aging and disease
    Tejero J, Lazure F, Gomes AP · Trends Endocrinol Metab · 2024
  23. 23
    Role of Vitamin B in Healthy Ageing and Disease
    Mikkelsen K, Trapali M, Apostolopoulos V · Subcell Biochem · 2024
  24. 24
    Mitochondrial GTP metabolism controls reproductive aging in C. elegans
    Lee YT, Savini M, Chen T et al. · Dev Cell · 2023
  25. 25
    'Closing the loop': re-audit of the diagnosis and management of vitamin B12 deficiency in general practice
    O'Donnell O, MacCarthy J · Ir J Med Sci · 2023