Evidence base

Studies on Astaxanthin

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

4,492 studies total·Last updated: June 4, 2026Open on PubMed

Skin · 60

Open on PubMed
  1. 01
    Radioprotective and wound healing potential of nanoemulsions and nanoliposomes encapsulating enriched astaxanthin extract fromHaematococcus pluvialis
    Vu NB, Nguyen MH, Tran TN et al. · Biomed Mater · 2026
  2. 02
    Unlocking the anti-aging potential: In silico analysis of astaxanthin, curcumin, quercetin, and resveratrol in modulating skin aging pathways
    Barbosa DG, Barbosa KRM, Guaitolini YM et al. · Comput Biol Chem · 2026
  3. 03
    Comparative evaluation of lipid-based nanocarriers encapsulating enriched astaxanthin extract from haematococcus pluvialis: preparation, characterization, and UVB protection
    Vu NB, Ngo DN, Tran TN et al. · Int J Radiat Biol · 2026
  4. 04
    [Effect and mechanism of astaxanthin on the aging of high glucose-treated human skin fibroblasts]
    Tang LJ, Fan LH, Wang JR et al. · Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi · 2025
  5. 05
    Oral administration of astaxanthin mitigates chronological skin aging in mice
    Liu S, Manabe Y, Sugawara T · Biosci Biotechnol Biochem · 2025
  6. 06
    The whitening efficacy of a compound formula examined using an ultraviolet-induced skin melanization model
    Shu X, Dong X, Ma Y et al. · J Cosmet Dermatol · 2024
  7. 07
    An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial
    Lopresti AL, Smith SJ, Riggs ML et al. · Nutrients · 2024RCT
  8. 08
    Astaxanthin Expedites the Healing of Acute Skin Wounds in Rats by Facilitating M2 Macrophage Polarization and Enhancing Collagen Secretion
    Gao HD, Zheng HL · Discov Med · 2024
  9. 09
    Possibility of nanostructured lipid carriers encapsulating astaxanthin from Haematococcus pluvialis to alleviate skin injury in radiotherapy
    Vu NB, Pham ND, Tran TN et al. · Int J Radiat Biol · 2024
  10. 10
    Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why
    Januszewski J, Forma A, Zembala J et al. · Medicina (Kaunas) · 2023
  11. 11
    A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric
    Konisky H, Bowe WP, Yang P et al. · J Cosmet Dermatol · 2023
  12. 12
    Preparation and in vitro characterization studies of astaxanthin-loaded nanostructured lipid carriers with antioxidant properties
    Gu L, Wang W, Wu B et al. · J Biomater Appl · 2023
  13. 13
    The combined effect of commercial tilapia collagen peptides and antioxidants against UV-induced skin photoaging in mice
    Song B, Liu D, Liu TC et al. · Food Funct · 2023
  14. 14
    Oral Supplementation with Z-Isomer-Rich Astaxanthin Inhibits Ultraviolet Light-Induced Skin Damage in Guinea Pigs
    Honda M, Kageyama H, Zhang Y et al. · Mar Drugs · 2022
  15. 15
    Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers
    Heo Y, Shin SW, Kim DS et al. · Biomater Sci · 2022
  16. 16
    Exploring the Potential of Nannochloropsis sp. Extract for Cosmeceutical Applications
    Kim SY, Kwon YM, Kim KW et al. · Mar Drugs · 2021
  17. 17
    Role of ingestible carotenoids in skin protection: A review of clinical evidence
    Baswan SM, Klosner AE, Weir C et al. · Photodermatol Photoimmunol Photomed · 2021
  18. 18
    Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing
    Zhou X, Cao Q, Orfila C et al. · Nutrients · 2021Meta
  19. 19
    Dermocosmetic applications of microalgal pigments
    Baby AR, Morocho-Jácome AL · Adv Appl Microbiol · 2021
  20. 20
    Xanthophyll Carotenoids Reduce the Dysfunction of Dermal Fibroblasts to Reconstruct the Dermal Matrix Damaged by Carbonylated Proteins
    Yamawaki Y, Mizutani T, Okano Y et al. · J Oleo Sci · 2021
  21. 21
    Effects of Astaxanthin Supplementation on Skin Health: A Systematic Review of Clinical Studies
    Ng QX, De Deyn MLZQ, Loke W et al. · J Diet Suppl · 2021SR
  22. 22
    Improved Anti-Inflammatory Effects of Liposomal Astaxanthin on a Phthalic Anhydride-Induced Atopic Dermatitis Model
    Lee YS, Jeon SH, Ham HJ et al. · Front Immunol · 2020
  23. 23
    On a Beam of Light: Photoprotective Activities of the Marine Carotenoids Astaxanthin and Fucoxanthin in Suppression of Inflammation and Cancer
    Catanzaro E, Bishayee A, Fimognari C · Mar Drugs · 2020
  24. 24
    Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics
    Alves A, Sousa E, Kijjoa A et al. · Molecules · 2020
  25. 25
    Protective effects of astaxanthin on skin: Recent scientific evidence, possible mechanisms, and potential indications
    Singh KN, Patil S, Barkate H · J Cosmet Dermatol · 2020

Longevity & aging · 54

Open on PubMed
  1. 01
    Lipid- and Polymer-Based Nanoscale Delivery of Anti-Aging Phytochemicals
    Gross S, Vogtlander C, Lewis C et al. · Wiley Interdiscip Rev Nanomed Nanobiotechnol · 2026
  2. 02
    Tapioca starch nanoparticles loaded with astaxanthin extend the lifespan of Caenorhabditis elegans by activating DAF-16
    Chen W, Song B, Xia W et al. · J Sci Food Agric · 2026
  3. 03
    [Effect and mechanism of astaxanthin on the aging of high glucose-treated human skin fibroblasts]
    Tang LJ, Fan LH, Wang JR et al. · Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi · 2025
  4. 04
    Astaxanthin prevents postovulatory oocyte aging by targeting TNFR2 and inhibiting the TNF signaling pathway
    Wen X, Han Z, Yang Q et al. · BMC Biol · 2025
  5. 05
    Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions
    Elmansi AM, Kassem A, Castilla RM et al. · Geroscience · 2025
  6. 06
    Intermittent fasting applied in combination with astaxanthin alleviates D-galactose-induced aging in rats: Comparison in oxidative stress, immune response, and metabolomics
    Chen Z, Xiao J, Zhao K et al. · J Food Sci · 2025
  7. 07
    Astaxanthin promotes the longevity of Caenorhabditis elegans via modulation of the intracellular redox status and PHA-4-mediated autophagy
    Ding F, Zhao Y · Food Funct · 2025
  8. 08
    Astaxanthin attenuates UV-irradiation aging process via activating JNK-1/DAF-16 in Caenorhabditis elegans
    Lin X, Shao CS, Elsherbiny SM et al. · Photochem Photobiol · 2025
  9. 09
    A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age
    McGee KC, Sullivan J, Hazeldine J et al. · Geroscience · 2024
  10. 10
    Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
    Harrison DE, Strong R, Reifsnyder P et al. · Geroscience · 2024
  11. 11
    The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway
    Aziz MM, El-Sheikh MM, Mohamed MA et al. · Int J Immunopathol Pharmacol · 2024
  12. 12
    Astaxanthin, Haematococcus pluvialis and Haematococcus pluvialis Residue Alleviate Liver Injury in D-Galactose-induced Aging Mice through Gut-liver Axis
    Zhang Y, Gao C, Zhu M et al. · J Oleo Sci · 2024
  13. 13
    Status of Research on Sestrin2 and Prospects for its Application in Therapeutic Strategies Targeting Myocardial Aging
    Dai G, Li M, Xu H et al. · Curr Probl Cardiol · 2023
  14. 14
    Toxicology of pharmaceutical and nutritional longevity compounds
    Kahraman C, Kaya Bilecenoglu D, Sabuncuoglu S et al. · Expert Rev Mol Med · 2023
  15. 15
    A novel peptide derived from Haematococcus pluvialis residue exhibits anti-aging activity in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway
    He W, Xie J, Xia Z et al. · Food Funct · 2023
  16. 16
    Astaxanthin delays brain aging in senescence-accelerated mouse prone 10: inducing autophagy as a potential mechanism
    Fu M, Liang X, Zhang X et al. · Nutr Neurosci · 2023
  17. 17
    Dietary supplementation with astaxanthin alleviates ovarian aging in aged laying hens by enhancing antioxidant capacity and increasing reproductive hormones
    He W, Wang H, Tang C et al. · Poult Sci · 2023
  18. 18
    Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review
    Alugoju P, Krishna Swamy VKD, Anthikapalli NVA et al. · Crit Rev Food Sci Nutr · 2023
  19. 19
    Astaxanthin attenuates irradiation-induced osteoporosis in mice by inhibiting oxidative stress, osteocyte senescence, and SASP
    Geng Q, Wang S, Heng K et al. · Food Funct · 2022
  20. 20
    Curcumin improves D-galactose and normal-aging associated memory impairment in mice: In vivo and in silico-based studies
    Rahman MA, Shuvo AA, Bepari AK et al. · PLoS One · 2022
  21. 21
    Ginsenoside Rg1 and astaxanthin act on the hypothalamus to protect female mice against reproductive aging
    Dai X, Zeng G, Hong L et al. · Chin Med J (Engl) · 2022
  22. 22
    DAF-16 acts as the "hub" of astaxanthin's anti-aging mechanism to improve aging-related physiological functions in Caenorhabditis elegans
    Liu X, Liu H, Chen Z et al. · Food Funct · 2021
  23. 23
    Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing
    Zhou X, Cao Q, Orfila C et al. · Nutrients · 2021Meta
  24. 24
    [Effects of astaxanthin combined with aerobic exercise on renal aging of rat induced by D-galactose and its mechanism]
    Niu YL, Cao JM, Zhou QY et al. · Zhongguo Ying Yong Sheng Li Xue Za Zhi · 2021
  25. 25
    Autophagy Plays a Role in the Prolongation of the Life Span of Caenorhabditis elegans by Astaxanthin
    Fu M, Zhang X, Zhang X et al. · Rejuvenation Res · 2021