CognitiveModerate evidence

Caffeine

The world's most-used stimulant — effective for acute alertness and athletic performance. But: the longevity benefits of coffee and green tea come from their polyphenols, not from caffeine.

Also known as: koffein, coffein, caffeine

How it works

Caffeine blocks the brain's adenosine receptors; adenosine builds up through the day and makes us sleepy. This raises alertness, reaction time and perceived energy, and measurably improves endurance performance. The effect blunts with habituation, and late intake disrupts sleep.

Goals
CognitionEnergyMuscle & strength
Timing
Morning
Price tier
Low

Dosage

Ergogenic from ~3 mg/kg body weight before exercise. Up to ~400 mg/day is generally considered safe; effect and tolerance vary strongly by genetics.

Considerations

An honest take: caffeine boosts alertness and short-term performance — but the long-term health benefits of coffee and green tea come from their accompanying compounds (polyphenols, catechins), not isolated caffeine. Isolated and high-dose it has downsides: disrupted sleep (half-life ~5–6 h), restlessness/anxiety, transient blood-pressure rise, tolerance and withdrawal headaches. If you want the longevity effect, coffee or green tea beats caffeine pills.

VeganNot during pregnancy
Form
CapsulePowder

Scientific detail

Mechanisms
Adenosine receptor antagonism (alertness)Increased catecholamine releaseErgogenic effect in sport
Evidence base

Studies on Caffeine

36,782 studies total · Open on PubMed

View all studies

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