Evidence base

Studies on Collagen (Collagen Peptides)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

1,111 studies total·Last updated: June 4, 2026Open on PubMed

Skin · 198

Open on PubMed
  1. 01
    Topical and systemic skin aging interventions: Evidence, pitfalls and perspectives
    Gürtler AL, Sirois JP, Heckenbach IJ et al. · Biochem Pharmacol · 2026
  2. 02
    Vasorelaxing Effect of Hydrolyzed Collagen from Salmon Skin in the Thoracic Aorta and Underlying Mechanisms
    Mungmuang P, Onsa-Ard A, Tocharus J et al. · Int J Mol Sci · 2026
  3. 03
    Oral Fish Collagen Peptide Complex Enhances Skin Rejuvenation and Systemic Health Biomarkers: A 90 Day Prospective Observational Study
    Huang J, Chen C, Zhang M et al. · J Cosmet Dermatol · 2026
  4. 04
    Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation
    Hwang S, Won J, Kim S et al. · J Med Food · 2026RCT
  5. 05
    Hydrolyzed Collagen from Salmon Skin Mitigates L-NAME-Induced Hypertension in Rats by Attenuating Oxidative Stress and Inflammation and Improving Vascular Remodeling
    Mungmuang P, Tocharus J, Panthiya L et al. · Int J Mol Sci · 2026
  6. 06
    Tilapia skin collagen peptides‑calcium chelates:Structural characterization, stability, in vitro and in vivo anti-osteoporosis mechanism
    Xie X, Zhang MT, Huang CL et al. · Food Res Int · 2026
  7. 07
    New Insights into the Anti-Aging Mechanism of Collagen Peptides-Emphasis on Lysosomes and Mitochondria Function
    Huang W, Ran J, Du Y et al. · Molecules · 2026
  8. 08
    Collagen and Collagen Peptide From the Alosa Sapidissima Protect Against UVB-Induced Skin Damage
    Cui J, Zhou Z, Han W et al. · Biotechnol Bioeng · 2026
  9. 09
    Development and Characterization of Collagen Dressings With Jatropha mutabilis Stalk Extract in the Scar Repair Process in Rodents
    Coelho CB, Dos Santos Cerqueira Alves C, Novaes GUM et al. · Biopolymers · 2026
  10. 10
    Isolation and characterization of bioactive collagen peptides from sea bass scales and their anti-photoaging effects
    Liu D, Ren Y, Zhong S et al. · Food Chem · 2025
  11. 11
    Trimethyl Chitosan-Engineered Cod Skin Peptide Nanosystems Alleviate Behavioral and Cognitive Deficits in D-Galactose-Induced Alzheimer's Disease Model Mice
    Kong S, Lv L, Guo J et al. · Mar Drugs · 2025
  12. 12
    The Human-Like Collagen Alpha-1 Type V Peptides Strengthen the Dermal Fiber Network and Improve the Regeneration Ability of Cells
    Kim YH, Kim BK, Nam YK et al. · J Cosmet Dermatol · 2025
  13. 13
    In Vitro Bioactivity of a Recombinant Human Collagen Peptide in a Filler Biomimetic Skin Model
    He C, Wang R, Zhang Q et al. · J Cosmet Dermatol · 2025
  14. 14
    The Sustained Effects of Bioactive Collagen Peptides on Skin Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study
    Wang Y, Zhu W, Luo W et al. · J Cosmet Dermatol · 2025RCT
  15. 15
    Collagen peptides derived from sea bass scales (Lateolabrax maculatus) relieve photoaging through MAPK, NF-κB and TGF-β signaling pathways and modulating gut microbiota composition
    Liu D, Ren Y, Peng Y et al. · Food Res Int · 2025
  16. 16
    Machine learning-guided anti-photoaging peptides from Chinese giant salamander skin: Efficient preparation and mechanistic insights
    Zhou Y, Zhang H, Zhao C et al. · Food Chem · 2025
  17. 17
    Current Insights and Future Directions in Scar Management and Skin Regeneration
    Szlachcikowska D, Mazurek K, Magiera M et al. · Int J Mol Sci · 2025
  18. 18
    Starfish-Derived Extracts Enhance Mitophagy and Suppress Senescence-Associated Markers in Human Dermal Fibroblasts
    Lee HJ, Kim J, Won B et al. · Mar Drugs · 2025
  19. 19
    Recombinant type I & III chimeric collagen significantly enhances the vitality of fibroblasts and decelerates the skin aging process
    Chen W, Wang N, Xie X et al. · BMC Biotechnol · 2025
  20. 20
    Anti-photoaging activity of cod peptides: structural characterisation and clinical validation
    He L, Liu R, Chen L et al. · Food Funct · 2025
  21. 21
    Chelation of cerium (III) with fish skin collagen peptides: Improving the in vitro stability and bioavailability of inorganic cerium
    Wu P, Tu Z, Wang H et al. · Food Res Int · 2025
  22. 22
    [Roles of different types of collagen in skin aging and their research progress]
    Li Y, Sun C, Liu Z et al. · Sheng Wu Gong Cheng Xue Bao · 2025
  23. 23
    Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
    Lee E, Ahn DK, Kim JH et al. · J Microbiol Biotechnol · 2025RCT
  24. 24
    Oral Use of Collagen Supplements in Dermatology
    Haralović V, Sjerobabski Masnec I · Acta Dermatovenerol Croat · 2025
  25. 25
    Oral Collagen Oligopeptides as a Modulator of Skin Health: A Comprehensive Evaluation of Clinical and Molecular Effects
    Zague V, Pinheiro ALTA, Pinto JR et al. · J Med Food · 2025RCT

Joints · 79

Open on PubMed
  1. 01
    Distinct HLA Associations for Antibody Multireactivity With Citrulline-Containing Type II Collagen Epitopes Versus More Limited Antibody Reactivity With Citrulline-Containing IgG Epitopes in Rheumatoid Arthritis
    Bashar SJ, Myhr CB, Titi AH et al. · Arthritis Rheumatol · 2026
  2. 02
    Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging
    Schurman CA, Bons J, Woo JJ et al. · Bone Res · 2026
  3. 03
    Collagen Supplementation Augments Strength Training-Induced Gains in Tendon Size and Rate of Force Development in Elite Female Master Field Hockey Athletes
    Nulty CD, Erskine RM · Int J Sport Nutr Exerc Metab · 2025RCT
  4. 04
    High-intensity resistance training and collagen supplementation improve patellar tendon adaptations in professional female soccer athletes
    Lee J, Robshaw DC, Erskine RM · Exp Physiol · 2025RCT
  5. 05
    Functional Benefits of Low-Molecular-Weight Collagen Peptide in Achilles Tendon and Medial Collateral Ligament Injuries and Anterior Cruciate Ligament Transection-Induced Osteoarthritis
    Choi E, Kim M, Lee DH et al. · J Microbiol Biotechnol · 2025
  6. 06
    Efficacy of combined undenatured type II collagen and hydrolysed collagen supplementation in knee osteoarthritis: a randomised controlled trial
    Yuenyongviwat V, Anusitviwat C, Tuntarattanapong P et al. · Sci Rep · 2025RCT
  7. 07
    Dual-Compartment Anti-Inflammatory and Chondroprotective Effects of Intra-Articular Hydrolyzed Collagen in Experimental Osteoarthritis
    Dinç M, Soydemir ÖC, Karasu R et al. · Medicina (Kaunas) · 2025
  8. 08
    Efficacy of hydrolyzed collagen injections compared to platelet-rich plasma and hyaluronic acid in the treatment of patients with symptomatic knee osteoarthritis: a retrospective clinical study
    Heredia Sulbaran AA, Gomez PA · BMC Musculoskelet Disord · 2025
  9. 09
    Osteoarthritis in cats: what we know, and mostly, what we don't know. . . yet
    Lefort-Holguin M, Delsart A, Frézier M et al. · J Feline Med Surg · 2025
  10. 10
    [Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations]
    Naumov AV, Unkovskiy AV, Khovasova NO et al. · Ter Arkh · 2025RCT
  11. 11
    Hydrolysed Collagen Supplementation Enhances Patellar Tendon Adaptations to 12 Weeks' Resistance Training in Middle-Aged Men
    Nulty CD, Phelan K, Erskine RM · Eur J Sport Sci · 2025RCT
  12. 12
    The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study
    Genç AS, Yılmaz AK, Anıl B et al. · BMC Musculoskelet Disord · 2025RCT
  13. 13
    Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study
    Genç AS, Yılmaz AK, Anıl B et al. · Jt Dis Relat Surg · 2025RCT
  14. 14
    Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials
    Simental-Mendía M, Ortega-Mata D, Acosta-Olivo CA et al. · Clin Exp Rheumatol · 2025Meta
  15. 15
    Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability
    Devasia S, Joseph JT, P S S et al. · Cartilage · 2024RCT
  16. 16
    The oral intake of specific Bioactive Collagen Peptides (BCP) improves gait and quality of life in canine osteoarthritis patients-A translational large animal model for a nutritional therapy option
    Dobenecker B, Böswald LF, Reese S et al. · PLoS One · 2024
  17. 17
    Preparation, typical structural characteristics and relieving effects on osteoarthritis of squid cartilage type II collagen peptides
    Zhao Q, Li Z, Liu Z et al. · Food Res Int · 2024
  18. 18
    Impact of Specific Bioactive Collagen Peptides on Joint Discomforts in the Lower Extremity during Daily Activities: A Randomized Controlled Trial
    Schulze C, Schunck M, Zdzieblik D et al. · Int J Environ Res Public Health · 2024RCT
  19. 19
    Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction
    Puigdellívol Grifell J, Comellas Berenguer C, Steinbacher G et al. · J Diet Suppl · 2024
  20. 20
    Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults
    Kviatkovsky SA, Hickner RC, Cabre HE et al. · J Int Soc Sports Nutr · 2023RCT
  21. 21
    Specific collagen peptides increase adaptions of patellar tendon morphology following 14-weeks of high-load resistance training: A randomized-controlled trial
    Jerger S, Centner C, Lauber B et al. · Eur J Sport Sci · 2023RCT
  22. 22
    Comparison of Single and Combined Treatment with Exercise Therapy and Collagen Supplementation on Early Knee Arthritis among Athletes-A Quasi-Randomized Trial
    Thomas DT, Prabhakar AJ, Eapen C et al. · Int J Environ Res Public Health · 2023RCT
  23. 23
    The Effect of Specific Bioactive Collagen Peptides on Tendon Remodeling during 15 wk of Lower Body Resistance Training
    Balshaw TG, Funnell MP, McDermott EJ et al. · Med Sci Sports Exerc · 2023RCT
  24. 24
    Analgesic efficacy of collagen peptide in knee osteoarthritis: a meta-analysis of randomized controlled trials
    Lin CR, Tsai SHL, Huang KY et al. · J Orthop Surg Res · 2023
  25. 25
    Response letter to the editor regarding "Collagen supplementation for rheumatoid arthritis and osteoarthritis"
    Jabbari M, Barati M · Int J Rheum Dis · 2023