Evidence base

Studies on Niacin (Vitamin B3)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

46,211 studies total·Last updated: June 4, 2026Open on PubMed

Metabolic health · 2,222

Open on PubMed
  1. 01
    Assessing valproate-induced changes in NADH levels in patients with type 2 diabetes using a silver nanoparticle-based method: An in-vitro study
    Esmaeeli S, Khoubnasabjafari M, Rahimpour E et al. · J Pharm Biomed Anal · 2026
  2. 02
    Structure-guided design of aspalathin-inspired chalcone analogs as direct AMPK activators with superior antihyperglycemic and hepatorenal protective effects
    Bojja KS, Holla H, Gawli K · Bioorg Chem · 2026
  3. 03
    Modulation of oxidative biomarkers and carbohydrate metabolic enzyme activity by Hypsizygus ulmarius polysaccharide in streptozotocin/nicotinamide-induced diabetic rats
    Govindan S, Shanmugam J, Rajendran G et al. · Fitoterapia · 2026
  4. 04
    Methodological approaches for dissecting ferroptosis in lens epithelial cells and its role in diabetic cataract progression
    Xu H, Wang W, Li J et al. · Methods · 2026
  5. 05
    Empagliflozin and dapagliflozin, sodium glucose cotransporter 2 inhibitors, may improve cognitive dysfunctions: in silico and in vivo findings
    Kiyak-Kirmaci H, Hazar-Yavuz AN, Polat EB et al. · Behav Brain Res · 2026
  6. 06
    Effect of Nicotinamide Mononucleotide on Retinal Thickness of Older Patients With Diabetes Mellitus: A Placebo-Controlled, Double-Blind Study
    Shiraki A, Hara C, Akasaka H et al. · Geriatr Gerontol Int · 2026RCT
  7. 07
    Design, synthesis, and antidiabetic activity of new furan-clubbed 1,2,3-triazole derivatives as α-glucosidase inhibitors
    Devi P, Maity S, Singh A et al. · Future Med Chem · 2026
  8. 08
    Insulin resistance and SIRT1 dysregulation in neurodegenerative diseases
    Shah A, Doshi G · Ageing Res Rev · 2026
  9. 09
    Nicotinamide Riboside (NR) Supplementation Exerts Neuroprotective Effects in db/db Mouse Model of Type 2 Diabetes
    Hughes E, Barton K, Rizvi D et al. · J Mol Neurosci · 2026
  10. 10
    Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism
    Shirazi S, Esawi E, Nassar ZD et al. · J Cell Biochem · 2026
  11. 11
    Local apocynin improves acetylcholine- but not insulin-mediated vasodilation in the cutaneous microvasculature of women with a history of gestational diabetes
    Maurer GS, O'Neill BT, Jalal DI et al. · J Appl Physiol (1985) · 2026
  12. 12
    Adipose Tissue Resistance to the Antilipolytic Effect of Insulin and Niacin in Humans With Obesity
    Lin S, Lytle KA, Fink N et al. · Diabetes · 2026
  13. 13
    Chiral gold nanoparticle synergizes immunometabolic crosstalk and metabolism remodeling for diabetic wound healing
    Zheng H, Wang X, Gao Z et al. · Biomaterials · 2026
  14. 14
    Niacin Derivatives in MASLD: Metabolic and Therapeutic Insights
    Rojo-López MI, Niño-Narvión J, Antentas M et al. · Nutrients · 2026
  15. 15
    Therapeutic Efficacy of S-Allyl-L-Cysteine an Active Constituent of Aged Garlic Extract in Rat Model of Gestational Diabetes Mellitus
    Wang J, Ma L, Yan X et al. · Cell Biochem Funct · 2026
  16. 16
    Nutrient Matrix-Supplying Hydrogel for Chlorella vulgaris Promotes Diabetic Wound Healing
    Zhang H, Liu D, Lv Y et al. · ACS Biomater Sci Eng · 2026
  17. 17
    Noncatechin flavonoid-rich extract from Camellia sinensis (L.) Kuntze seed residues ameliorates diabetes and vascular complications in SHRs
    Shen KP, Lin SY, Hao CL et al. · J Pharm Pharmacol · 2026
  18. 18
    Silicon-Enriched Restructured Meat Mitigates Metabolic Dysfunction-Associated Steatohepatitis in a Late-Stage Type 2 Diabetes Mellitus Rat Model
    Redondo-Castillejo R, Hernández-Martín M, Bocanegra A et al. · Mol Nutr Food Res · 2026
  19. 19
    Effects of Progranulin Deficiency on Inflammation and Fibrosis in the Kidneys and Liver of Diabetic Mice Fed a High-Fat Diet
    Sakuma H, Murakoshi M, Hagiwara S et al. · Endocrinol Metab (Seoul) · 2026
  20. 20
    Single-cell sequencing reveals that neutrophils mediate the inflammatory response in the placenta of women with GDM
    Yin S, Zhuo N, Duan Q et al. · J Mol Histol · 2026
  21. 21
    The role of probiotics in modulating the gut microbiota as a potential inhibitor of diabetic kidney disease progression
    Costa VCS, Pinheiro MM, Cabreira GT et al. · J Bras Nefrol · 2026
  22. 22
    Effects of thymoquinone on cognitive functions and kynurenine metabolites induced in rats by streptozotocin/nicotinamide
    Hazar-Yavuz AN, Kiyak-Kirmaci H, Aktas HS et al. · Eur J Pharmacol · 2026
  23. 23
    Aqueous Extract of Opuntia ficus-indica (L. Mill) Cladodes Demonstrates Antidiabetic Effect in Normoglycemic and STZ-Induced Diabetic Rats
    Masango NE, Asiamah EA, Martey O et al. · Biomed Res Int · 2026
  24. 24
    Erythrocyte Integrity, Thymocyte Volume Regulation, and Functional State of the Heart during Ischemia/Reperfusion in Rats with Type 2 Diabetes Mellitus
    Khamidova OJ, Oljaev ND, Fayziev DD et al. · Bull Exp Biol Med · 2026
  25. 25
    Protective effects of the NAMPT activator P7C3-A20 on mouse neuronal injury in diabetic stroke: The role of intracellular NAMPT and SIRT1/FoxO3a signaling
    Iwatani Y, Hayashi H, Minamisawa M et al. · Biomed Pharmacother · 2026

Longevity & aging · 936

Open on PubMed
  1. 01
    Iridoids from the edible flowers of Rhododendron pachypodum: structural elucidation and healthspan related bioactivities in Caenorhabditis elegans
    Wang Y, Zhang HR, Luan J et al. · Phytochemistry · 2026
  2. 02
    An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT
    Sun Y, Han JC, Tran K et al. · Redox Biol · 2026
  3. 03
    NAD⁺ as a central metabolic hub Regulating the hallmarks of aging: Mechanisms and therapeutic implications
    Pei Z, Liang F, Wang X et al. · Mech Ageing Dev · 2026
  4. 04
    Sarcopenia: An overview of emerging therapies and pathophysiological insights in age-related skeletal muscle decline
    Mishra D, Mohapatra L · Biochem Pharmacol · 2026
  5. 05
    β-Nicotinamide mononucleotide prevents senescence and lipid accumulation in hepatic stellate cells by restoring SIRT1 function
    Saka T, Hayashi R, Yoshino Y et al. · Chem Biol Interact · 2026
  6. 06
    Ameliorative Effects of Butyrylated Starch on Cognitive Dysfunction in d-Galactose-Induced Aging Mice: A Comparative Analysis with Exogenous Butyrate and Resistant Starch
    Zhang Y, Zhao B, Li L et al. · J Agric Food Chem · 2026
  7. 07
    DRP1 in reproduction and reproductive aging
    Huang CR, Cheng YH, Chang YC et al. · Biol Reprod · 2026
  8. 08
    Molecular mechanisms of SIRT1 in regulating ageing and related intervention strategies
    Sun Y, Dai X, Lin Y et al. · Mol Biol Rep · 2026
  9. 09
    Intracellular NAD(+) Depletion Increases Prostanoid Production via p38/COX2 Signalling in FK866-Induced Senescent Human Umbilical Vein Endothelial Cells
    Kitajima N, Nakajo T, Katayoshi T et al. · J Cell Mol Med · 2026
  10. 10
    Exosome-Delivered eNAMPT From Exercise Activates SIRT1 to Counteract Age-Related Hepatic Steatosis and Fibrosis
    Song W, Wu N, Li X et al. · Aging Cell · 2026
  11. 11
    The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging
    Kojima D, Yaku K, Kosugi S et al. · Aging Cell · 2026
  12. 12
    Nicotinamide Mononucleotide Improves High-Fat Diet-Induced Myocardial Damage of Aging Mice through the Sirt3/PINK1/Parkin Signaling Pathway
    Wen X, Chen YN, Han YC et al. · J Nutr · 2026
  13. 13
    Sirt1-eIF2α axis drives pro-inflammatory macrophage activation through ER stress aggravating liver IRI in aged mice
    Zhou Y, Wu X, Xu X et al. · Biochem Biophys Res Commun · 2026
  14. 14
    SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways
    Weiss B, Miranda DR, Arrazati D et al. · Drug Des Devel Ther · 2026
  15. 15
    Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism
    Shirazi S, Esawi E, Nassar ZD et al. · J Cell Biochem · 2026
  16. 16
    Endothelial NAD(+) depletion drives vascular senescence and neuroinflammation via mtDNA-cGAS/STING-CD38 signaling in Alzheimer's disease
    Luo QH, Li F, Yang L et al. · Alzheimers Dement · 2026
  17. 17
    Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration
    Yu J, Hou M, Deng Y et al. · Aging Cell · 2026
  18. 18
    Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle
    Turner DC, Raastad T, Ullrich M et al. · Adv Sci (Weinh) · 2026
  19. 19
    NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence
    Gallagher C, Emmanuel OO · Ageing Res Rev · 2026
  20. 20
    The effect of obesity and aging on NAD(+)/Sirtuin metabolism transcription and DNA methylation in subcutaneous adipose tissue of monozygotic twin pairs discordant for BMI
    Lapatto HAK, van der Kolk BW, Muniandy M et al. · Int J Obes (Lond) · 2026
  21. 21
    Treatment of age-related decreases in GTP levels restores endocytosis and autophagy
    Santana RA, McWhirt JM, Brewer GJ · Geroscience · 2026
  22. 22
    Nicotinamide riboside treatment enhances stress sensitivity and modulates hematological dynamics in aged mice
    Culig L, Kashyap A, Kuribayashi W et al. · Geroscience · 2026
  23. 23
    Kynurenine pathway dysregulation via loss of QPRT drives declines in activity and altered metabolism in mice
    Westbrook R, Menon V, Cagmat J et al. · Geroscience · 2026
  24. 24
    Uranium exposure induces osteopenia via mitochondrial dysfunction-driven senescence in bone marrow mesenchymal stem cells
    Sheng L, Suo Y, Hong S et al. · J Hazard Mater · 2026
  25. 25
    NAD(+) controls circadian rhythmicity during cardiac aging
    Carpenter BJ, Lecacheur M, Mangold YN et al. · Commun Biol · 2026

Cardiovascular · 3,808

Open on PubMed
  1. 01
    Acetylation of PRDX5 aggravates the oxidative stress and apoptosis of retinal neurons induced by ischemia-reperfusion
    Lu S, Wang L, Wang K et al. · Tissue Cell · 2026
  2. 02
    ROCK Inhibition Reprograms Microglial Polarization to Promote Neuroprotection via NOX2/ROS/TXNIP Suppression
    Wang Z, Xu X, Wang L et al. · Antioxid Redox Signal · 2026
  3. 03
    The Role of the Pentose Phosphate Pathway in Cardiovascular Diseases
    Chen Z, Zhang Y, Qian C et al. · Cardiovasc Drugs Ther · 2026
  4. 04
    NADPH exerts neuroprotection in ischemic stroke by reinforcing blood-brain barrier integrity and stimulating angiogenesis
    Xu H, Zhang H, Shi RR et al. · Neuropharmacology · 2026
  5. 05
    Microenvironmental Drivers of Bone Disease in Multiple Myeloma: Oxidative Stress, Sterile Inflammation, Autophagy-Lysosomal Remodeling, and the Iron-Lipid Peroxidation Axis
    Nasso ME, Bottaro A, Fazio M et al. · Biomolecules · 2026
  6. 06
    SIRT1 in Cardiac Diseases: Molecular Mechanisms, Therapeutic Potential, and Future Directions
    Chang Y, Li L, Yue H · Int J Mol Sci · 2026
  7. 07
    Effect of Nicotinamide Mononucleotide on Retinal Thickness of Older Patients With Diabetes Mellitus: A Placebo-Controlled, Double-Blind Study
    Shiraki A, Hara C, Akasaka H et al. · Geriatr Gerontol Int · 2026RCT
  8. 08
    Thomas Willis Lecture Award: Nature's Blueprint for Ischemic Tolerance: Preconditioning and Postconditioning Strategies
    Perez-Pinzon MA · Stroke · 2026
  9. 09
    Dual Single-Atom Engineered NADH Oxidase-Mimic Boosts In Situ NAD(+) Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection
    Liu J, Guo X, Wang N et al. · Adv Mater · 2026
  10. 10
    Neutrophil-Driven Cascade-Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia-Reperfusion Injury
    Ma H, Li Y, Lin S et al. · Adv Sci (Weinh) · 2026
  11. 11
    Pregnancy precipitates metabolic imbalance and accelerates death in an animal model of mitochondrial cardiomyopathy
    Sayles NM, Casalena G, Zhao D et al. · Mol Metab · 2026
  12. 12
    In vivo dynamic nuclear polarization magnetic resonance imaging reveals cardiac mitochondrial redox imbalance as an early indicator of heart failure
    Ichihashi K, Hyodo F, Elsayed Elhelaly A et al. · Redox Biol · 2026
  13. 13
    Sirt1-eIF2α axis drives pro-inflammatory macrophage activation through ER stress aggravating liver IRI in aged mice
    Zhou Y, Wu X, Xu X et al. · Biochem Biophys Res Commun · 2026
  14. 14
    Modulating CD38 enzymatic activity during antibody-based immunotherapy in multiple myeloma: a basic science perspective
    Horenstein AL, Frerichs KA, Faini AC et al. · Front Immunol · 2026
  15. 15
    Relationship between dietary thiamine, riboflavin, and niacin intake and hypertension subtypes: A cross-sectional study from the 1999-2023
    Ma S, Jin Q, Yu K et al. · PLoS One · 2026
  16. 16
    Identifying a fatty acid metabolic gene signature in diabetic cardiomyopathy through integrated bioinformatics and machine learning
    Wei A, Zhang H, He O et al. · Biochem Biophys Res Commun · 2026
  17. 17
    Effects of manual acupuncture on microglial polarization and the Sirt1/NF-κB pathway in a rat model of post-stroke depression
    Li M, Yang X, Ran D et al. · Acupunct Med · 2026
  18. 18
    NMRK2-YAP-NADK axis preserves redox protection against myocardial ischemia/reperfusion injury
    Zhang C, Wang J, Chi J et al. · Redox Biol · 2026
  19. 19
    Impact of conventional lipid-lowering therapy on circulating levels of proprotein convertase subtilisin/kexin type 9: A systematic review and meta-analysis of randomised controlled trials
    Meng L, Huang T, Guo S et al. · Diabetes Obes Metab · 2026
  20. 20
    Research status and molecular mechanisms of disulfidptosis in cardiovascular diseases (Review)
    Jin X, Cheng Z, Ding X et al. · Mol Med Rep · 2026
  21. 21
    Astaxanthin protects retinal Müller cells against high glucose-induced oxidative stress through the sirtuin 1/AMPK/FOXO1 pathway
    Tew TB, Yang CH · Exp Eye Res · 2026
  22. 22
    Nicotinamide prevents anti-PD1 immune checkpoint inhibitor-associated early stages of cardiotoxicity
    Bai L, Zhao J, Dong K et al. · Sci China Life Sci · 2026
  23. 23
    [Advances in research on the mechanisms of reactive oxygen species in platelet activation and thrombosis]
    Shen RY, Xu KL, Qiao JL et al. · Zhonghua Xue Ye Xue Za Zhi · 2026
  24. 24
    Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Zhang M, Chen Y, Jiang N et al. · Nutrients · 2026SR
  25. 25
    Decreased risk of cardiovascular disease in dermatology patients taking niacinamide: A TriNetX cohort study
    Salem Y, Liaqat M, Gonna N et al. · J Am Acad Dermatol · 2026