Evidence base

Studies on Nicotinamide Riboside (NR)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

906 studies total·Last updated: June 4, 2026Open on PubMed

Longevity & aging · 84

Open on PubMed
  1. 01
    An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT
    Sun Y, Han JC, Tran K et al. · Redox Biol · 2026
  2. 02
    SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways
    Weiss B, Miranda DR, Arrazati D et al. · Drug Des Devel Ther · 2026
  3. 03
    Endothelial NAD(+) depletion drives vascular senescence and neuroinflammation via mtDNA-cGAS/STING-CD38 signaling in Alzheimer's disease
    Luo QH, Li F, Yang L et al. · Alzheimers Dement · 2026
  4. 04
    Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle
    Turner DC, Raastad T, Ullrich M et al. · Adv Sci (Weinh) · 2026
  5. 05
    NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence
    Gallagher C, Emmanuel OO · Ageing Res Rev · 2026
  6. 06
    Nicotinamide riboside treatment enhances stress sensitivity and modulates hematological dynamics in aged mice
    Culig L, Kashyap A, Kuribayashi W et al. · Geroscience · 2026
  7. 07
    NAD(+) controls circadian rhythmicity during cardiac aging
    Carpenter BJ, Lecacheur M, Mangold YN et al. · Commun Biol · 2026
  8. 08
    The Use of Nutritional Interventions to Enhance Genomic Stability in Mice and Delay Aging
    van Galen I, Hoeijmakers JHJ, Vermeij WP · Nutrients · 2026
  9. 09
    Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) - possible combination use
    Ulpathakumbura S, Lu SK, Gunarathne R et al. · Ageing Res Rev · 2026
  10. 10
    Urolithin Α modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing
    Roussos A, Kitopoulou K, Borbolis F et al. · Autophagy · 2025
  11. 11
    Preventive and Protective Effects of Nicotinamide Adenine Dinucleotide Boosters in Aging and Retinal Diseases
    Noreen S, Lim SS, Lee D · Int J Mol Sci · 2025
  12. 12
    Ganoderma lucidum sporoderm-broken spore powder alleviates kidney aging by modulating gut microbiota
    Liu X, Zhao J, Liu J et al. · J Ethnopharmacol · 2025
  13. 13
    Emerging strategies, applications and challenges of targeting NAD(+) in the clinic
    Zhang J, Wang HL, Lautrup S et al. · Nat Aging · 2025
  14. 14
    Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
    Ali MM, Nookaew I, Resende-Coelho A et al. · J Biol Chem · 2025
  15. 15
    Nicotinic acid riboside maintains NAD(+) homeostasis and ameliorates aging-associated NAD(+) decline
    Song WS, Shen X, Du K et al. · Cell Metab · 2025
  16. 16
    Nicotinamide Riboside Supplementation Alleviates Testicular Aging Induced by Disruption of Qprt-Dependent NAD(+) De Novo Synthesis in Mice
    Xu Y, Wang H, Li H et al. · Aging Cell · 2025
  17. 17
    Nicotinamide riboside alleviates ionizing radiation-induced intestinal senescence by alleviating oxidative damage and regulating intestinal metabolism
    Yue T, Dong Y, Huo Q et al. · J Adv Res · 2025
  18. 18
    Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation
    Lautrup S, Zhang SQ, Funayama S et al. · Aging (Albany NY) · 2025
  19. 19
    Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
    Fang Z, Raza U, Song J et al. · ESC Heart Fail · 2025
  20. 20
    Effect of Dietary Ketosis and Nicotinamide Riboside on Hippocampal Krebs Cycle Intermediates and Mitochondrial Energetics in a DNA Repair-Deficient 3xTg/POLβ(+/-) Alzheimer Disease Mouse Model
    Pawlosky R, Demarest TG, King MT et al. · J Neurochem · 2025
  21. 21
    The NAD(+) precursor nicotinamide riboside protects against postovulatory aging in vitro
    Li T, Wang Y, Yu Y et al. · J Assist Reprod Genet · 2024
  22. 22
    Cytochrome b(5) reductase 3 overexpression and dietary nicotinamide riboside supplementation promote distinctive mitochondrial alterations in distal convoluted tubules of mouse kidneys during aging
    Pérez-Rodríguez M, García-Verdugo A, Sánchez-Mendoza LM et al. · Aging Cell · 2024
  23. 23
    Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule
    Kelly G, Kataura T, Panek J et al. · Dev Cell · 2024
  24. 24
    Nicotinamide Mononucleotide and Nicotinamide Riboside Reverse Ovarian Aging in Rats Via Rebalancing Mitochondrial Fission and Fusion Mechanisms
    Arslan NP, Taskin M, Keles ON · Pharm Res · 2024
  25. 25
    The therapeutic perspective of NAD(+) precursors in age-related diseases
    Iqbal T, Nakagawa T · Biochem Biophys Res Commun · 2024

Energy & endurance · 96

Open on PubMed
  1. 01
    An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT
    Sun Y, Han JC, Tran K et al. · Redox Biol · 2026
  2. 02
    Glucocorticoid excess disrupts NAD+ homeostasis in male and female mice
    Heaselgrave SR, Heising S, Deng M et al. · J Endocrinol · 2026
  3. 03
    NAMPT Deficiency Promotes Endothelial-Mesenchymal Transition by Inhibiting Energy Metabolism and Lysosomal Acidification in Late-Onset Fuchs Endothelial Corneal Dystrophy
    Xie L, Chen M, Wu J et al. · Invest Ophthalmol Vis Sci · 2026
  4. 04
    Long-term region-specific mitochondrial respiration impairment after perinatal asphyxia is prevented by the NAD⁺ donor nicotinamide riboside: A real-time organotypic metabolic profiling approach
    Díaz-Urbina E, Almarza C, Davidson H et al. · Pharmacol Res · 2026
  5. 05
    Pregnancy precipitates metabolic imbalance and accelerates death in an animal model of mitochondrial cardiomyopathy
    Sayles NM, Casalena G, Zhao D et al. · Mol Metab · 2026
  6. 06
    ATF5-mediated mitochondrial UPR inhibited RANKL in Porphyromonas gingivalis LPS-treated osteoblasts
    Yang T, Sun W, Lei L · Arch Oral Biol · 2026
  7. 07
    NMRK2-YAP-NADK axis preserves redox protection against myocardial ischemia/reperfusion injury
    Zhang C, Wang J, Chi J et al. · Redox Biol · 2026
  8. 08
    Maternal Immune Activation Leads to Mitochondrial Dysfunction and a Social Deficit in Offspring That Is Reversed by Nicotinamide Riboside
    Bazhin AA, Solodnikova ES, San Miguel DA et al. · Nutrients · 2026
  9. 09
    Reduced Versus Oxidized NAD(+) Precursors Drive Distinct Transcriptomic, Proteomic, and Metabolic Profiles in Hepatocytes
    Vinten KT, Schomakers BV, Denis S et al. · FASEB J · 2026
  10. 10
    Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4(+) T cells
    Stavrou V, Ali M, Gudgeon N et al. · Nat Commun · 2026
  11. 11
    NAD+ and Sirt5 restore mitochondrial bioenergetics failure and improve locomotor defects caused by sucla2 mutations
    Richard J, Lizzo G, Rochat N et al. · JCI Insight · 2026
  12. 12
    Targeting PGC-1α axis rescues aberrant development from thyroid hormone defect in brain organoids
    Bottani E, Ciarpella F, Lucidi B et al. · Pharmacol Res · 2026
  13. 13
    NAD(+) dyshomeostasis in RYR1-related myopathies
    Lawal TA, Riekhof W, Groom L et al. · Skelet Muscle · 2025
  14. 14
    Nicotinamide riboside promoted cardiac energetics and alleviated doxorubicin-induced cardiotoxicity via SIRT1/ERRα signal in human pluripotent stem cells-derived cardiomyocytes
    Wang R, Zhang H, Yi Q et al. · Life Sci · 2025
  15. 15
    Immature Acta2(R179C/+) smooth muscle cells cause moyamoya-like cerebrovascular lesions in mice prevented by boosting OXPHOS
    Kaw A, Majumder S, Esparza Pinelo JE et al. · Nat Commun · 2025
  16. 16
    Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective
    Yu F, Zhao H, Luo L et al. · Nutrients · 2025
  17. 17
    Defective Mitochondrial Respiration in Hereditary Thoracic Aneurysms
    Marcos-Ríos D, Rochano-Ortiz A, Méndez-Barbero N et al. · Cells · 2025
  18. 18
    UPR(mt) alleviates bone cancer pain through the restoration of mitochondrial function
    Li D, Xie M, Zeng H et al. · Exp Cell Res · 2025
  19. 19
    The protection of nicotinamide riboside against diabetes mellitus-induced bone loss via OXPHOS
    Gao J, Meng X, Yang X et al. · Bone · 2025
  20. 20
    NAD+ prevents chronic kidney disease by activating renal tubular metabolism
    Jones BA, Gisch DL, Myakala K et al. · JCI Insight · 2025
  21. 21
    Nicotinamide riboside supplementation ameliorates ovarian dysfunction in a PCOS mouse model
    Zhu Z, Lei M, Guo R et al. · J Ovarian Res · 2025
  22. 22
    Novel Molecules Targeting Metabolism and Mitochondrial Function in Cardiac Diseases
    Gonzalez SB, Trincado CV, Rodriguez KPT et al. · Curr Cardiol Rev · 2025
  23. 23
    Effect of Dietary Ketosis and Nicotinamide Riboside on Hippocampal Krebs Cycle Intermediates and Mitochondrial Energetics in a DNA Repair-Deficient 3xTg/POLβ(+/-) Alzheimer Disease Mouse Model
    Pawlosky R, Demarest TG, King MT et al. · J Neurochem · 2025
  24. 24
    Cardiac NAD(+) depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics
    Doan KV, Luongo TS, Ts'olo TT et al. · Nat Cardiovasc Res · 2024
  25. 25
    Nicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner
    Marmolejo-Garza A, Chatre L, Croteau DL et al. · Neurobiol Dis · 2024

Metabolic health · 39

Open on PubMed
  1. 01
    Nicotinamide Riboside (NR) Supplementation Exerts Neuroprotective Effects in db/db Mouse Model of Type 2 Diabetes
    Hughes E, Barton K, Rizvi D et al. · J Mol Neurosci · 2026
  2. 02
    AGK2 and nicotinamide riboside reveal SIRT2's protective role in a diabetic-dietary rat model of NASH via deacetylation of NLRP3, LKB1, and FOXO3a and restoration of AMPK-ACC/PGC-1α-Nrf2 signaling
    Hamad RS, Hasan WA, Elmorsy EA et al. · Int Immunopharmacol · 2026
  3. 03
    Stimulator of interferon genes: A potential target for treating type 2 diabetes mellitus
    Ding X, Wang W, Wu J et al. · Biochem Pharmacol · 2026
  4. 04
    Nicotinamide riboside supplementation protects against maternal diabetes-associated decline in oocyte quality
    Wei C, Zeng X, Wang K et al. · Reproduction · 2025
  5. 05
    The protection of nicotinamide riboside against diabetes mellitus-induced bone loss via OXPHOS
    Gao J, Meng X, Yang X et al. · Bone · 2025
  6. 06
    Enhancing wound healing via modulation of autophagy-induced apoptosis: the role of nicotinamide riboside and resveratrol in streptozotocin-treated diabetic rat
    Siri M, Maleki MH, Meybodi SM et al. · J Nutr Biochem · 2025
  7. 07
    Feasibility of telehealth exercise and nicotinamide riboside supplementation in survivors of childhood cancer at risk for diabetes: A pilot randomized controlled trial
    Bhandari R, Lukas K, Lee K et al. · Pediatr Blood Cancer · 2025RCT
  8. 08
    Loss of NAMPT and SIRT2 but not SIRT1 attenuate GLO1 expression and activity in human skeletal muscle
    Miranda ER, Varshney P, Mazo CE et al. · Redox Biol · 2024
  9. 09
    Boosting wound healing in diabetic rats: The role of nicotinamide riboside and resveratrol in UPR modulation and pyroptosis inhibition
    Hasan Maleki M, Siri M, Jafarabadi A et al. · Int Immunopharmacol · 2024
  10. 10
    NAD(+) Precursors Reverse Experimental Diabetic Neuropathy in Mice
    Chandrasekaran K, Najimi N, Sagi AR et al. · Int J Mol Sci · 2024
  11. 11
    NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease
    Myakala K, Wang XX, Shults NV et al. · J Biol Chem · 2023
  12. 12
    Nicotinamide Riboside Improves Enteric Neuropathy in Streptozocin-Induced Diabetic Rats Through Myenteric Plexus Neuroprotection
    Costa CJ, Cohen MW, Goldberg DC et al. · Dig Dis Sci · 2023
  13. 13
    Improving Mitochondrial Function in Skeletal Muscle Contributes to the Amelioration of Insulin Resistance by Nicotinamide Riboside
    Li Q, Jiang X, Zhou Y et al. · Int J Mol Sci · 2023
  14. 14
    Dietary supplementation with nicotinamide riboside improves fetal growth under hypoglycemia
    Lee SR, Jeong SH, Mukae M et al. · J Nutr Biochem · 2023
  15. 15
    Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure
    Cercillieux A, Ratajczak J, Joffraud M et al. · Mol Metab · 2022
  16. 16
    Reduction of Obesity and Insulin Resistance through Dual Targeting of VAT and BAT by a Novel Combination of Metabolic Cofactors
    Quesada-Vázquez S, Antolín A, Colom-Pellicer M et al. · Int J Mol Sci · 2022
  17. 17
    Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome
    Tyagi A, Musa M, Labeikovsky W et al. · Sci Rep · 2022
  18. 18
    NAD(+) Precursors Repair Mitochondrial Function in Diabetes and Prevent Experimental Diabetic Neuropathy
    Chandrasekaran K, Najimi N, Sagi AR et al. · Int J Mol Sci · 2022
  19. 19
    Nicotinamide riboside promotes Mfn2-mediated mitochondrial fusion in diabetic hearts through the SIRT1-PGC1α-PPARα pathway
    Hu L, Guo Y, Song L et al. · Free Radic Biol Med · 2022
  20. 20
    Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females
    In Het Panhuis W, Tsaalbi-Shtylik A, Schönke M et al. · Am J Physiol Endocrinol Metab · 2022
  21. 21
    Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice
    Lozada-Fernández VV, deLeon O, Kellogg SL et al. · mSystems · 2022
  22. 22
    Regulation of NAD(+) metabolism in aging and disease
    Chu X, Raju RP · Metabolism · 2022
  23. 23
    Supplementation with a Specific Combination of Metabolic Cofactors Ameliorates Non-Alcoholic Fatty Liver Disease, Hepatic Fibrosis, and Insulin Resistance in Mice
    Quesada-Vázquez S, Colom-Pellicer M, Navarro-Masip È et al. · Nutrients · 2021
  24. 24
    Nicotinamide riboside has minimal impact on energy metabolism in mouse models of mild obesity
    Cartwright DM, Oakey LA, Fletcher RS et al. · J Endocrinol · 2021
  25. 25
    NAD(+)-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin
    Li DJ, Sun SJ, Fu JT et al. · Theranostics · 2021