Evidence base

Studies on PQQ (Pyrroloquinoline Quinone)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

1,403 studies total·Last updated: June 4, 2026Open on PubMed

Energy & endurance · 345

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  1. 01
    Mechanistic study on PQQ improving the quality of aged bovine oocytes and early embryonic developmental potential via Nrf2-mediated redox signaling
    You BY, Wu HK, Zhou XY et al. · Cell Signal · 2026
  2. 02
    An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT
    Sun Y, Han JC, Tran K et al. · Redox Biol · 2026
  3. 03
    Characterization of a membrane-bound PQQ-dependent D-lactate dehydrogenase in Gluconobacter japonicus
    Kataoka N, Takeuchi S, Maeno S et al. · Appl Microbiol Biotechnol · 2026
  4. 04
    PQQ Modulates Cell Cycle and DNA Replication Programs to Alleviate Replicative Senescence in Human Umbilical Cord Mesenchymal Stromal Cells
    Wang S, Lu F, Tan C et al. · Stem Cell Rev Rep · 2026
  5. 05
    Functional organization and regulatory logic of the ped gene cluster in Pseudomonas species
    Puiggené Ò, Nikel PI · Appl Environ Microbiol · 2026
  6. 06
    Synthetic Biology Strategies for Harnessing Bacterial Glucose Oxidation Pathways
    Wang R, Feng P, Wang Q et al. · ACS Synth Biol · 2026
  7. 07
    Improvement of spermogenesis impairment induced by high-fat diet in obese mice through pyrroloquinoline quinone regulation of glycolysis pathway
    Huang Q, Wei Y, Fu Z et al. · J Nutr Biochem · 2026
  8. 08
    Pyrroloquinoline quinone activates lactate and inhibits NLRP3 to improve ovarian reserve in premature ovarian insufficiency
    Liu K, Lei S, Li B et al. · Reprod Biomed Online · 2025
  9. 09
    The Natural Redox Cofactor Pyrroloquinoline Quinone (PQQ) Enables Photocatalytic Radical Cyclizations
    Bahukhandi SB, Klein AS, Mustafa G et al. · Angew Chem Int Ed Engl · 2025
  10. 10
    In Hyphomicrobium denitrificans Two Related Sulfane-Sulfur Responsive Transcriptional Repressors Regulate Thiosulfate Oxidation and Have a Deep Impact on Nitrate Respiration and Anaerobic Biosyntheses
    Li J, Schmitte NE, Törkel K et al. · Mol Microbiol · 2025
  11. 11
    Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin
    Ellerhorst M, Nikitushkin V, Al-Jammal WK et al. · Nat Prod Rep · 2025
  12. 12
    Creation of a highly stable direct electron transfer-type enzyme sensor by combining a hyperthermophilic dehydrogenase and natural electron mediator
    Maeno M, Sakuraba H, Ohshima T et al. · Biotechnol Lett · 2025
  13. 13
    Electrochemical immunosensors based on the solubility difference of electroactive probe and the dual signal amplification of nanocarrier plus redox cycling
    Chang Y, Wang Y, Fan X et al. · Bioelectrochemistry · 2025
  14. 14
    Characterization of Tetrathionate Hydrolase from Acidothermophilic Sulfur-Oxidizing Archaeon Metallosphaera cuprina Ar-4
    Wang P, Li LZ, Liu LJ et al. · Int J Mol Sci · 2025
  15. 15
    Pyrroloquinoline quinone exhibiting peroxidase-mimicking property for colorimetric assays
    Xia N, Gao F, Liu G et al. · Anal Chim Acta · 2025
  16. 16
    Extensive and diverse lanthanide-dependent metabolism in the ocean
    Voutsinos MY, Banfield JF, McClelland HO · ISME J · 2025
  17. 17
    Gold Nanoparticles-Based Colorimetric Immunoassay of Carcinoembryonic Antigen with Metal-Organic Framework to Load Quinones for Catalytic Oxidation of Cysteine
    Yu ZJ, Yang TT, Liu G et al. · Sensors (Basel) · 2024
  18. 18
    All lactose-oxidizing enzymes of Pseudomonas taetrolens, a highly efficient lactobionic acid-producing microorganism, are pyrroloquinoline quinone-dependent enzymes
    Lee SS, Oh YR, Jang YA et al. · Int Microbiol · 2024
  19. 19
    Development of an electrochemical impedance spectroscopy immunosensor for insulin monitoring employing pyrroloquinoline quinone as an ingestible redox probe
    Khanwalker M, Hatada M, LaBelle JT et al. · Biosens Bioelectron · 2024
  20. 20
    Nanobody-guided redox and enzymatic functionalization of icosahedral virus particles for enhanced bioelectrocatalysis
    Kassem R, Cousin A, Clesse D et al. · Bioelectrochemistry · 2024
  21. 21
    Improving the alcohol respiratory chain and energy metabolism by enhancing PQQ synthesis in Acetobacter pasteurianus
    Zhang W, Feng C, Zhang C et al. · J Ind Microbiol Biotechnol · 2024
  22. 22
    Comment on "Humic acid-dependent respiratory growth of Methanosarcina acetivorans involves pyrroloquinoline quinone" by Yuanxu Song et al
    Lovley DR, Holmes DE · ISME J · 2024
  23. 23
    Response to comment on "Humic acid-dependent respiratory growth of Methanosarcina acetivorans involves pyrroloquinoline quinone" by Yuanxu Song et al
    Song Y, Huang R, Li L et al. · ISME J · 2024
  24. 24
    Microbial synthesis of pyrroloquinoline quinone
    Gao H, Wang Y, Yang J et al. · World J Microbiol Biotechnol · 2023
  25. 25
    Identification and characterization of a novel pathway for aldopentose degradation in Acinetobacter baumannii
    Alberti L, König P, Zeidler S et al. · Environ Microbiol · 2023

Longevity & aging · 25

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  1. 01
    An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT
    Sun Y, Han JC, Tran K et al. · Redox Biol · 2026
  2. 02
    Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction
    Yu K, Wang N, Huang X et al. · Aging Cell · 2026
  3. 03
    Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation
    Xue Q, Gu Y, Qin R et al. · Phytomedicine · 2026
  4. 04
    PQQ Modulates Cell Cycle and DNA Replication Programs to Alleviate Replicative Senescence in Human Umbilical Cord Mesenchymal Stromal Cells
    Wang S, Lu F, Tan C et al. · Stem Cell Rev Rep · 2026
  5. 05
    Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) - possible combination use
    Ulpathakumbura S, Lu SK, Gunarathne R et al. · Ageing Res Rev · 2026
  6. 06
    Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells
    Jiang B, Zhang H, Xu Q et al. · Aging Cell · 2025
  7. 07
    Assessment of the Capability of Mesenchymal Stem Cells and/or Pyrroloquinoline Quinone in Compensating the Age-Related Dysfunctions of AMP-Activated Protein Kinase Pathway in Wistar Rats
    Al Nishilli KM, El Zayat EM, Abdelgayed SS et al. · Cell Biochem Biophys · 2025
  8. 08
    Pyrroloquinoline Quinone Reprograms the Single-Cell Landscape of Immune Aging in Hematopoietic Immune System
    Liu X, Zhang C, Lv J et al. · Aging Cell · 2025
  9. 09
    Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice
    Xue Q, Li J, Qin R et al. · Aging Cell · 2024
  10. 10
    Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation
    Li J, Zhang J, Xue Q et al. · Aging Cell · 2023
  11. 11
    Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice
    Gao Y, Kamogashira T, Fujimoto C et al. · Sci Rep · 2022
  12. 12
    Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD
    Mandala A, Dobrinskikh E, Janssen RC et al. · Int J Mol Sci · 2022
  13. 13
    Research Note: Dietary supplementation with pyrroloquinoline quinone disodium (PQQ.Na(2)) improves oxidative status and semen quality in aging layer breeder roosters
    Long C, Wang Z, Guo Y et al. · Poult Sci · 2022SR
  14. 14
    Repression of the Antioxidant Pyrroloquinoline Quinone in Skin Aging Induced by Bmi-1 Deficiency
    Li J, Liu M, Liang S et al. · Biomed Res Int · 2022
  15. 15
    Pyrroloquinoline quinone extends Caenorhabditis elegans' longevity through the insulin/IGF1 signaling pathway-mediated activation of autophagy
    Yang L, Ye Q, Zhang X et al. · Food Funct · 2021
  16. 16
    1,25-Dihydroxyvitamin D deficiency accelerates male reproductive senescence in aging mice and 1,25(OH)(2)D(3) alleviates oxidative stress via NF-κB/SOD
    He J, Wang H, Shi J et al. · Am J Physiol Endocrinol Metab · 2021
  17. 17
    Pyrroloquinoline quinone delays inflammaging induced by TNF-α through the p16/p21 and Jagged1 signalling pathways
    Hao J, Ni X, Giunta S et al. · Clin Exp Pharmacol Physiol · 2020
  18. 18
    Protective effects of pyrroloquinoline quinine against oxidative stress-induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1/Nrf2 signaling pathway
    Wang Z, Han N, Zhao K et al. · Int Immunopharmacol · 2019
  19. 19
    Pyrroloquinoline Quinone Prevents Estrogen Deficiency-Induced Osteoporosis by Inhibiting Oxidative Stress and Osteocyte Senescence
    Geng Q, Gao H, Yang R et al. · Int J Biol Sci · 2019
  20. 20
    Prolonging healthy aging: Longevity vitamins and proteins
    Ames BN · Proc Natl Acad Sci U S A · 2018
  21. 21
    Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans
    Sasakura H, Moribe H, Nakano M et al. · J Cell Sci · 2017
  22. 22
    Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans
    Wu JZ, Huang JH, Khanabdali R et al. · Exp Gerontol · 2016
  23. 23
    Protective effect of pyrroloquinoline quinine on ultraviolet A irradiation-induced human dermal fibroblast senescence in vitro proceeds via the anti-apoptotic sirtuin 1/nuclear factor-derived erythroid 2-related factor 2/heme oxygenase 1 pathway
    Zhang C, Wen C, Lin J et al. · Mol Med Rep · 2015
  24. 24
    Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats
    Singh AK, Pandey SK, Saha G et al. · Exp Gerontol · 2015
  25. 25
    Effect of vitamin E on learning and memory deficit in aged rats
    Takatsu H, Owada K, Abe K et al. · J Nutr Sci Vitaminol (Tokyo) · 2009

Cognition · 11

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  1. 01
    The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial
    Baltic S, Nedeljkovic D, Todorovic N et al. · J Nutr Health Aging · 2024RCT
  2. 02
    The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes
    Ikemoto K, Mohamad Ishak NS, Akagawa M · J Med Invest · 2024
  3. 03
    Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
    Shiojima Y, Takahashi M, Takahashi R et al. · J Am Nutr Assoc · 2022RCT
  4. 04
    Modulating NMDA receptors to treat MK-801-induced schizophrenic cognition deficit: effects of clozapine combining with PQQ treatment and possible mechanisms of action
    Zhou X, Cai G, Mao S et al. · BMC Psychiatry · 2020
  5. 05
    PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3β/Akt signaling pathway in mouse
    Zhou XQ, Yao ZW, Peng Y et al. · Sci Rep · 2018
  6. 06
    Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease
    Martino Adami PV, Quijano C, Magnani N et al. · J Cereb Blood Flow Metab · 2017
  7. 07
    Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions
    Itoh Y, Hine K, Miura H et al. · Adv Exp Med Biol · 2016RCT
  8. 08
    Pyrroloquinoline quinone prevents MK-801-induced stereotypical behavior and cognitive deficits in mice
    Zhou X, Chen Q, Hu X et al. · Behav Brain Res · 2014
  9. 09
    Symptom-specific self-referential cognitive processes in bipolar disorder: a longitudinal analysis
    Pavlickova H, Varese F, Turnbull O et al. · Psychol Med · 2013
  10. 10
    Potential physiological importance of pyrroloquinoline quinone
    Rucker R, Chowanadisai W, Nakano M · Altern Med Rev · 2009
  11. 11
    Effect of vitamin E on learning and memory deficit in aged rats
    Takatsu H, Owada K, Abe K et al. · J Nutr Sci Vitaminol (Tokyo) · 2009