Evidence base

Studies on Pterostilbene

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

1,104 studies total·Last updated: June 4, 2026Open on PubMed

Longevity & aging · 25

Open on PubMed
  1. 01
    Natural senotherapeutics in respiratory health: Addressing cellular senescence, inflammaging, and immunosenescence in the aging lung
    Juan ME, Verdaguer E, Prohens R et al. · Eur J Pharmacol · 2026
  2. 02
    Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging
    Afzal M, Rekha MM, Sahoo S et al. · Inflammopharmacology · 2025
  3. 03
    Pterostilbene enhances reproductive outcomes and oocyte quality in aged mice without adverse effects
    Okamoto N, Sato Y, Kawagoe Y et al. · Aging (Albany NY) · 2025
  4. 04
    Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats
    Tello-Palencia MA, Yang T, Sularz O et al. · Mol Nutr Food Res · 2024
  5. 05
    Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts
    Hartinger R, Singh K, Leverett J et al. · Biomolecules · 2024
  6. 06
    Polystyrene nanoplastics exposure triggers spermatogenic cell senescence via the Sirt1/ROS axis
    Liang Y, Yang Y, Lu C et al. · Ecotoxicol Environ Saf · 2024
  7. 07
    Resveratrol and Its Analogues: Anti-ageing Effects and Underlying Mechanisms
    Zhou DD, Cheng J, Li J et al. · Subcell Biochem · 2024
  8. 08
    Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline
    Dutta BJ, Rakshe PS, Maurya N et al. · Ageing Res Rev · 2023
  9. 09
    Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions
    Freeberg KA, Udovich CC, Martens CR et al. · J Gerontol A Biol Sci Med Sci · 2023
  10. 10
    A comprehensive overview of the complex relationship between epigenetics, bioactive components, cancer, and aging
    Kocabas Ş, Sanlier N · Crit Rev Food Sci Nutr · 2023
  11. 11
    Suppressive effects of pterostilbene on human cytomegalovirus (HCMV) infection and HCMV-induced cellular senescence
    Wang S, Zhou X, He X et al. · Virol J · 2022
  12. 12
    Pterostilbene Promotes Mean Lifespan in Both Male and Female Drosophila Melanogaster Modulating Different Proteins in the Two Sexes
    Beghelli D, Zallocco L, Barbalace MC et al. · Oxid Med Cell Longev · 2022
  13. 13
    Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1
    Zhang L, Zheng J, Tie X et al. · Can J Physiol Pharmacol · 2021
  14. 14
    Stilbene Compounds Inhibit Tumor Growth by the Induction of Cellular Senescence and the Inhibition of Telomerase Activity
    Lee YH, Chen YY, Yeh YL et al. · Int J Mol Sci · 2019
  15. 15
    Selectivity of Dietary Phenolics for Inhibition of Human Monoamine Oxidases A and B
    Zhang Z, Hamada H, Gerk PM · Biomed Res Int · 2019
  16. 16
    Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study
    La Spina M, Sansevero G, Biasutto L et al. · Cell Physiol Biochem · 2019
  17. 17
    Effect of resveratrol and pterostilbene on aging and longevity
    Li YR, Li S, Lin CC · Biofactors · 2018
  18. 18
    A multimethod computational simulation approach for investigating mitochondrial dynamics and dysfunction in degenerative aging
    Hoffman TE, Barnett KJ, Wallis L et al. · Aging Cell · 2017
  19. 19
    P53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment
    Chen RJ, Wu PH, Ho CT et al. · Cell Death Dis · 2017
  20. 20
    The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans
    Fischer N, Büchter C, Koch K et al. · J Pharm Pharmacol · 2017
  21. 21
    Effects of pterostilbene and resveratrol on brain and behavior
    Poulose SM, Thangthaeng N, Miller MG et al. · Neurochem Int · 2015
  22. 22
    A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorders
    Cherniack EP · Br J Nutr · 2012
  23. 23
    Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
    Chang J, Rimando A, Pallas M et al. · Neurobiol Aging · 2012
  24. 24
    [Chemical principles and bioactivities of blueberry]
    Chen CF, Li YD, Xu Z · Yao Xue Xue Bao · 2010
  25. 25
    Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging
    Joseph JA, Fisher DR, Cheng V et al. · J Agric Food Chem · 2008

Metabolic health · 45

Open on PubMed
  1. 01
    Multifunctional fibrous membranes based on poly(ε-caprolactone)/ methacrylamide chitosan loaded with VEGF-mimetic peptide for promoting diabetic wound healing
    Li X, Yang A, Hou X et al. · Int J Biol Macromol · 2025
  2. 02
    Hypoglycemic Effect of Rambutan (Nephelium lappaceum L.) Peel Polyphenols on Type 2 Diabetes Mice by Modulating Gut Microbiota and Metabolites
    Liu Q, Ma Q, Li J et al. · Mol Nutr Food Res · 2024
  3. 03
    Pterostilbene Ameliorates Cognitive Impairment in Polycystic Ovary Syndrome Rat Model through Improving Insulin Resistance via the IRS-1/PI3K/Akt/GSK-3β Pathway: A Comparative Study with Metformin
    Foda AM, Ibrahim SS, Ibrahim SM et al. · ACS Chem Neurosci · 2024
  4. 04
    Pterostilbene Reverses Epigenetic Silencing of Nrf2 and Enhances Antioxidant Response in Endothelial Cells in Hyperglycemic Microenvironment
    Harithpriya K, Ganesan K, Ramkumar KM · Nutrients · 2024
  5. 05
    Pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male Swiss albino mice and affects insulin resistance, inflammation, HPA axis dysfunction and SIRT1 mediated leptin-ghrelin signaling
    Patil R, Aswar U, Vyas N · Horm Behav · 2024
  6. 06
    Hypoglycemic effects and associated mechanisms of resveratrol and related stilbenes in diet
    Peng J, Lu C, Luo Y et al. · Food Funct · 2024
  7. 07
    [Evaluation of chemical constituents of Draconis Sanguis and its protective effect on renal tubular injury in diabetic kidney disease]
    Zhou L, Duan YF, Wang YH et al. · Zhongguo Zhong Yao Za Zhi · 2024
  8. 08
    Pterostilbene accelerates wound healing response in diabetic mice through Nrf2 regulation
    Ganesh GV, Ramkumar KM · Mol Immunol · 2023
  9. 09
    Pterostilbene ameliorates type-2 diabetes mellitus - Induced depressive-like behavior by mitigating insulin resistance, inflammation and ameliorating HPA axis dysfunction in rat brain
    Patil R, Aswar U, Vyas N · Brain Res · 2023
  10. 10
    Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-кB pathway through microbiota-gut-brain axis
    Zhang ZT, Deng SM, Chen C et al. · Phytother Res · 2023
  11. 11
    Pterostilbene attenuates hemin-induced dysregulation of macrophage M2 polarization via Nrf2 activation in experimental hyperglycemia
    V Ganesh G, Ramkumar KM · Inflammopharmacology · 2023
  12. 12
    Therapeutic application of natural products: NAD(+) metabolism as potential target
    Guo C, Huang Q, Wang Y et al. · Phytomedicine · 2023
  13. 13
    Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes
    Damgaard MV, Jepsen SL, Ashcroft SP et al. · Nutrients · 2022
  14. 14
    Topical administration of pterostilbene accelerates burn wound healing in diabetes through activation of the HIF1α signaling pathway
    Hu W, Yu H, Zhou X et al. · Burns · 2022
  15. 15
    Pterostilbene and Its Derivative 3'-Hydroxypterostilbene Ameliorated Nonalcoholic Fatty Liver Disease Through Synergistic Modulation of the Gut Microbiota and SIRT1/AMPK Signaling Pathway
    Tsai HY, Shih YY, Yeh YT et al. · J Agric Food Chem · 2022
  16. 16
    Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet
    Gu W, Yang L, Wang X et al. · Kidney Blood Press Res · 2022
  17. 17
    Pterostilbene Ameliorates Renal Damage in Diabetic Rats by Suppressing Hyperglycemia with Inhibition of Inflammatory and Fibrotic Responses
    Ding RR, Huang GY, Zhang YJ et al. · Biomed Environ Sci · 2021
  18. 18
    Diabetes-induced auditory complications: are they preventable? a comprehensive review of interventions
    Hajiabolhassan F, Tavanai E · Eur Arch Otorhinolaryngol · 2021
  19. 19
    Dysregulation of Nrf2 redox pathway in macrophages under diabetic microenvironment
    Ganesh GV, Ramkumar KM · Exp Gerontol · 2021
  20. 20
    Pterostilbene Improves Insulin Resistance Caused by Advanced Glycation End Products (AGEs) in Hepatocytes and Mice
    Yu W, Fan L, Wang M et al. · Mol Nutr Food Res · 2021
  21. 21
    Nanoparticles prepared from pterostilbene reduce blood glucose and improve diabetes complications
    Zhao X, Shi A, Ma Q et al. · J Nanobiotechnology · 2021
  22. 22
    Fatty acid synthase inhibition ameliorates diabetes induced liver injury in rodent experimental model
    Bedi O, Srivastava N, Parsad D et al. · Eur J Pharmacol · 2021
  23. 23
    Pterostilbene influences glycemia and lipidemia and enhances antioxidant status in the liver of rats that consumed sucrose solution
    de Morais JMB, Cruz EMS, da Rosa CVD et al. · Life Sci · 2021
  24. 24
    Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids
    Gómez-Zorita S, Milton-Laskíbar I, Aguirre L et al. · Curr Med Chem · 2021
  25. 25
    Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting apoptosis
    Özdaş S, Taştekin B, Gürgen SG et al. · PLoS One · 2020