Evidence base

Studies on Rapamycin (Sirolimus)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

51,487 studies total·Last updated: June 4, 2026Open on PubMed

Longevity & aging · 1,558

Open on PubMed
  1. 01
    The metabolic-inflammatory axis in aging: A multi-organ framework anchored in Sarcopenia - A review
    Liang T · Arch Gerontol Geriatr · 2026
  2. 02
    Concept and connotation of the geroprotective and anti-aging effects of metformin: From AMPK activation to SASP suppression
    Aedh AI, Al-Kuraishy HM, Shokr MM et al. · Mol Cell Endocrinol · 2026
  3. 03
    Mechanistic insights into aging and longevity: Implications for ovarian function and health
    Harrath AH · Tissue Cell · 2026
  4. 04
    Limonin mitigates hepatic senescence and fibrosis in MASH mice by targeting STAT3 to inhibit Galectin-3/mTORC1 signaling
    Lan T, Wang W, Zeng XX et al. · Phytomedicine · 2026
  5. 05
    Insights into the therapeutic strategies for aging and aging-associated diseases
    Dong R, Wu Q, Kan J et al. · Signal Transduct Target Ther · 2026
  6. 06
    Why dietary interventions fail or succeed in ageing: Metabolic resilience as the missing integrative framework
    Murillo-Cancho AF, Lozano-Paniagua D, Martín-Latorre MDM et al. · Clin Nutr ESPEN · 2026
  7. 07
    IPMK-1 governs C. elegans physiology through ceTOR but lifespan via a distinct IP3-dependent pathway
    He XX, Huang Q, Yu XT et al. · Mech Ageing Dev · 2026
  8. 08
    Transcriptional network analysis of PTEN-protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
    Rondon-Lorefice I, Lopez JI, Ugalde-Olano A et al. · Mol Oncol · 2026
  9. 09
    Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging
    Torrent C, Gagliardi C, Fülle N et al. · PLoS One · 2026
  10. 10
    T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives
    Zhou S, Jian L, Chen H et al. · Clin Rev Allergy Immunol · 2026
  11. 11
    β-Ecdysterone Attenuates Ang II-Induced Senescence in Human Aortic Smooth Muscle Cells via Autophagy Activation and ROS Suppression Through AKT/mTOR Pathway Inhibition
    Wu D, Dong T, Li Y et al. · Front Biosci (Landmark Ed) · 2026
  12. 12
    Antagonistic pleiotropy governing reproductive aging: evolutionary regulation of endometrial receptivity
    Kobayashi H, Nishio M, Umetani M et al. · Reproduction · 2026
  13. 13
    Chronic rapamycin treatment attenuates age-related motor deficits in sex-dependent manner in UM-HET3 mice
    Singh R, Calderon VE, Holstein D et al. · J Gerontol A Biol Sci Med Sci · 2026
  14. 14
    Metformin beyond Glycemic Control: New Mechanistic Insights and Expanding Therapeutic Horizons
    Han E, Nam JH, Lee I et al. · Diabetes Metab J · 2026
  15. 15
    Transcriptomics analyses reveal microgravity triggers estrogen synthesis amidst degeneration and aging in human ovarian granulosa cells
    Yin C, Zhang J, Cheng Z et al. · Life Sci Space Res (Amst) · 2026
  16. 16
    5-Hydroxytryptamine 2B receptor antagonism restores ATP and reduces tubulointerstitial fibrosis in the renal cortices of aged mice
    McAlister KW, Scholpa NE, Thompson AD et al. · J Pharmacol Exp Ther · 2026
  17. 17
    Esketamine and postoperative cognitive dysfunction in aged mice: Role of the SIRT3/AMPK/mTOR pathway
    Wang Y, Cui T, Wang J et al. · Pak J Pharm Sci · 2026
  18. 18
    Pulmonary Vascular Signaling in Pulmonary Hypertension: Potential Role of Endothelial Ca(2+) Signaling in Cellular Senescence and Inflammasome Activation
    Wang WT, Li X, Wang T et al. · Arterioscler Thromb Vasc Biol · 2026
  19. 19
    Dietary Polyphenols in Aging: A Systems-Level Perspective on Mitochondrial Quality Control and Microbiome Interactions
    Yılmaz A, Park HJ, Ahn EM et al. · Int J Mol Sci · 2026
  20. 20
    Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans
    Lin YH, Liao YH, Liao SB et al. · J Biomed Sci · 2026
  21. 21
    SASP-driven vascular aging: unraveling the transcriptional nexus in endothelial senescence and cardiovascular disease
    Mao S, Cui J · Histochem Cell Biol · 2026
  22. 22
    Smoke Condensate-Induced Vascular Senescence and SASP Are Attenuated by Dual mTORC1/2 Inhibition with Rapalink-1
    You J, Liu H, Khan D et al. · Int J Mol Sci · 2026
  23. 23
    SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways
    Weiss B, Miranda DR, Arrazati D et al. · Drug Des Devel Ther · 2026
  24. 24
    Targeting the senescence-autophagy axis for idiopathic pulmonary fibrosis therapy
    Min JY, Choi E, Yoo YJ et al. · Trends Pharmacol Sci · 2026
  25. 25
    Amino acid metabolism modulates chronic kidney disease progression by mediating the aging process: Mechanistic insights and therapeutic interventions
    Song Y, Zhou H, Ye L et al. · Diabetes Obes Metab · 2026