Rapamycin (Sirolimus)
Perhaps the most exciting longevity compound in research — an mTOR inhibitor that reliably extends lifespan in animal models. In humans it's prescription-only, and as a longevity use it's off-label and unproven.
⚕ Only under medical supervision
This compound is a prescription drug, or a medication with relevant risks and interactions. We deliberately do not sell it and link no source of supply. Taking it belongs in a doctor's hands — this page is for neutral information only.
Discuss benefits, risks, and dosing with your physician.
How it works
Rapamycin inhibits mTOR, a central switch that drives growth under nutrient surplus and brakes the cell's waste disposal (autophagy). When mTOR is dampened, autophagy rises, which most robustly extends lifespan in animal models. In humans it's off-label and experimental; dosing and safety are decisive.
Dosage
The longevity scene discusses low, intermittent doses (off-label). Dosing strictly by a physician — rapamycin is approved as an immunosuppressant, not for life extension.
Considerations
The animal data are striking (lifespan extension across species; more in the piece on rapamycin & mTOR). In humans, long-term outcome studies are entirely lacking. It's a prescription immunosuppressant with real risks (infection susceptibility, metabolism, wound healing); intermittent low-dose use aims to mitigate this but is unproven. Conceivable only under specialized medical supervision.
