Evidence base

Studies on Resveratrol

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

20,831 studies total·Last updated: June 4, 2026Open on PubMed

Longevity & aging · 795

Open on PubMed
  1. 01
    Mechanistic insights into aging and longevity: Implications for ovarian function and health
    Harrath AH · Tissue Cell · 2026
  2. 02
    Environmental cadmium drives placental senescence and fetal growth restriction via activating CLPP-dependent mitochondrial stress
    Pan R, Zhang J, Wu LL et al. · J Hazard Mater · 2026
  3. 03
    Effects of resveratrol and nanodiamonds on sirtuin activity, oxidative stress and DNA damage in Acheta domesticus
    Ziętara-Krzyk P, Flasz B, Augustyniak M · Biochem Biophys Res Commun · 2026
  4. 04
    Computational exploration of squalene analog 4,4'diapophytofluene as a potential anti-aging phytotherapeutic
    Dutta M, Hazra A, Mandal Biswas S · Comput Biol Chem · 2026
  5. 05
    A covalent resveratrol-nitroxide conjugate protects against oxidative stress-induced cellular senescence
    Konopko A, Sęktas K, Targońska A et al. · Biomed Pharmacother · 2026
  6. 06
    Resveratrol induces molecular changes in cholesterol homeostasis in SAMP8 mice cerebellum
    Tejero A, Benito-Patón V, Griñán-Ferré C et al. · Biomed Pharmacother · 2026
  7. 07
    Dietary Polyphenols in Aging: A Systems-Level Perspective on Mitochondrial Quality Control and Microbiome Interactions
    Yılmaz A, Park HJ, Ahn EM et al. · Int J Mol Sci · 2026
  8. 08
    Exercise in a Pill: Emerging Therapeutics for Age-Related Orthopedic Diseases
    Luo J, Meng X, Han J et al. · Antioxid Redox Signal · 2026
  9. 09
    Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and Their Association With Cognitive Function in Aging and Neurodegenerative Diseases
    Wang L, Luo Z, Liu D · Phytother Res · 2026
  10. 10
    Vitisin B rejuvenates senescence via WBP2NL regulation
    Yoon JH, Lee YH, Oh S et al. · Mech Ageing Dev · 2026
  11. 11
    SIRT1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis
    Duan Y, Luo Y, Han X et al. · Cell Death Dis · 2026
  12. 12
    Evaluation of Molecular Responses and Longevity Markers in Acheta domesticus Following Combined Resveratrol and Nanodiamond Exposure
    Ziętara-Krzyk P, Flasz B, Augustyniak M · Int J Mol Sci · 2026
  13. 13
    Resveratrol Mitigates Age-Associated Cognitive Decline via Inhibition of cGAS-STING-Mediated Microglial Senescence
    Duan X, Cheng J, Wang J et al. · Cells · 2026
  14. 14
    Biologically Distinct, Clinically Convergent: A Comparative Study of Umbilical Cord- and Adipose-Derived Mesenchymal Stem Cell Exosomes in Human Skin Regeneration
    Ponnikorn S, Thanasarnaksorn W, Hongeng S et al. · Aesthet Surg J · 2026
  15. 15
    Resveratrol Improves Fine Motor Performance and Attenuates Oxidative Stress, GFAP Reactivity, and Purkinje Cell Loss in the Cerebellum of Male Rats After 12, 18, and 24 Months of Treatment
    Juarez D, Venegas B, Molina-Romero D et al. · Synapse · 2026
  16. 16
    Targeting senescent cells in aged adipose tissue induced by ovarian cancer with the NF-κB inhibitor quercetin and resveratrol impedes the growth and metastasis of ovarian cancer
    Lv J, Fan Q, Zhe J et al. · Sci China Life Sci · 2026
  17. 17
    Natural senotherapeutics in respiratory health: Addressing cellular senescence, inflammaging, and immunosenescence in the aging lung
    Juan ME, Verdaguer E, Prohens R et al. · Eur J Pharmacol · 2026
  18. 18
    Dietary (poly)phenols as modulators of natural killer cell function and immunosenescence: From molecular pathways to clinical evidence
    Acharya A, Mazzola G, Rondanelli M et al. · Phytomedicine · 2026SR
  19. 19
    SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditory cells
    Cho SI, Jo ER, Jang HS · Sci Rep · 2026
  20. 20
    Oxidative Stress and SIRT1-Nrf2 Anti-Ferroptotic Pathways in Granulosa Cells: A Molecular Key to Follicular Atresia and Ovarian Aging
    Voros C, Chatzinikolaou F, Papadimas G et al. · Int J Mol Sci · 2026
  21. 21
    FOXO: a key target in regulating aging and age-related diseases
    Wang W, Zhu H, Jiang Q et al. · Biogerontology · 2026
  22. 22
    TRIM37-PARP1-TET1 axis maintains stemness and prevents osteoporosis by inhibiting DNMT1 alternative splicing via 5hmC regulation
    Ho CT, Li LH, Chang WC et al. · Nat Commun · 2025
  23. 23
    Clinical Strategies for Counteracting Human Ovarian Aging: Molecular Background, Update, and Outlook
    Tesarik J, Mendoza Tesarik R · Int J Mol Sci · 2025
  24. 24
    The role of miR-217/SIRT1 Axis in modulating the NLRP3 Inflammasome in the naturally aging thoracic aorta and in endothelial cells undergoing senescence induced by H(2)O(2)
    Huang D, Shen K, Gui L et al. · Int Immunopharmacol · 2025
  25. 25
    Erythropoietin as a multifaceted antiaging agent: Mechanisms and clinical potential
    Wang T, Tang Y, Xiao Y · J Pharmacol Exp Ther · 2025

Cardiovascular · 1,554

Open on PubMed
  1. 01
    ANXA2, DBN1, ZNF385D, and IL6ST: Endothelial cell biomarkers linking atherosclerosis progression to immune microenvironment dysregulation
    Xue F, Shi Y, Zhang Y et al. · Clin Exp Hypertens · 2026
  2. 02
    Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis
    Gong D, Chen X, Dong Z et al. · Ren Fail · 2026
  3. 03
    The mechanism of Taohe Chengqi decoction in modulating inflammation and alleviating cerebral ischemia-reperfusion injury in rats through regulation of the arachidonic acid metabolism pathway and PI3K/AKT/HIF-1α signaling pathway
    Zhang Z, Wang H, Wang Y et al. · Fitoterapia · 2026
  4. 04
    Nanoplastics exacerbated renal injury amid hypertension: Rethinking health hazards in disease and implication of renal senescence and EMT associated with Sirt1 downregulation
    Liu Y, Ji D, Lin Y et al. · Environ Pollut · 2026
  5. 05
    Zn(2+)-dependent modulation of the mitochondrial Ca(2+) uniporter underlies resveratrol-mediated protection against myocardial ischemia-reperfusion injury
    Xing B, Li X, Wang B et al. · Exp Cell Res · 2026
  6. 06
    Healing the heart naturally: The role of bioactive phytocompounds in cardiovascular therapeutics
    Anand A, Srivastava S, Sharma D et al. · Phytomedicine · 2026
  7. 07
    Resveratrol modulates the sFRP4/Wnt signaling Pathway and preserves blood-brain barrier integrity in rats with ischemic stroke
    Zhang H, Xu Z, Wang Y et al. · Eur J Pharmacol · 2026
  8. 08
    The Potential Protective Effects of Resveratrol Against Cabazitaxel-Induced Oxidative Stress and Cardiotoxicity in Rats
    Khaled H, Farag A, Elfadadny A et al. · Cardiovasc Toxicol · 2026
  9. 09
    Structural Optimization of Pterostilbene, a Promising Lead Molecule, and Evaluation of Its Derivatives via ADMET Prediction and In Vitro/In Vivo Anti-Cerebral Ischemic Activity
    Zhang K, Li J, Dai Y et al. · Int J Mol Sci · 2026
  10. 10
    SIRT1 in Cardiac Diseases: Molecular Mechanisms, Therapeutic Potential, and Future Directions
    Chang Y, Li L, Yue H · Int J Mol Sci · 2026
  11. 11
    Effect of pterostilbene on cognitive function, and histone deacetylase and BDNF/CREB pathway following ischemia reperfusion injury in mice
    Tian S, Li Y, Kang J et al. · Behav Brain Res · 2026
  12. 12
    Engineered Microglial Exosome-Liposome Hybrid Nanovesicles for Synergistic Therapy of Hypoxic-Ischemic Encephalopathy by Dual-Targeting Ferroptosis and Neuroinflammation
    Wang C, Tian K, Jia C et al. · Adv Healthc Mater · 2026
  13. 13
    Targeting the Hippo pathway in pulmonary arterial hypertension: emerging pharmacological strategies
    Zheng D, Guo Y · J Hypertens · 2026
  14. 14
    Nature-Inspired Surface Modification Strategy Reverses the Autophagic Flux Impairment of Mitochondrial Transplantation for Attenuating Ischemic Strokes
    Wang N, Ding Q, Shi L et al. · Adv Sci (Weinh) · 2026
  15. 15
    Effect of compound fish oil capsules on microvascular function in hypertensive individuals: a triple-blind, randomized, placebo-controlled pilot trial
    Liu B, Wang W, Teng A et al. · Food Funct · 2026RCT
  16. 16
    Resveratrol and the neuroinflammation axis in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and cerebral ischemia
    Wang H, Li F, Wang H et al. · Front Immunol · 2026
  17. 17
    Modulation of Redox Balance by Phytochemicals: Implications for Cardiovascular Health
    Jaganjac M, Orie NN · Nutrients · 2026
  18. 18
    Peroxisome Proliferator-activated Receptors in Diabetic Retinopathy: Pathophysiologic Insights and Emerging Pharmacologic Strategies
    Mandujano-Ferrer L, Alemán-González-Duhart D · Can J Diabetes · 2026
  19. 19
    Resveratrol alleviated diabetic retinal neuronal ferroptosis induced by high glucose through inhibiting HIF-1α and HMOX1 pathway
    Ye M, Jiang Y, Gong H et al. · Exp Eye Res · 2026
  20. 20
    [Effects and mechanisms of resveratrol on vascular smooth muscle cell proliferation and neointimal hyperplasia in a carotid artery injury model]
    Li ZG, Zhou PL, Yuan HF et al. · Zhonghua Yi Xue Za Zhi · 2026
  21. 21
    SIRT1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis
    Duan Y, Luo Y, Han X et al. · Cell Death Dis · 2026
  22. 22
    Nature's Bioactives in Cardiorenal Syndrome: Polyphenols at the Crossroads-Preclinical Insights into Redox, Inflammation, and Mitochondrial Protection
    Carollo C, Ciuppa ME, Sorce A et al. · Nutrients · 2026
  23. 23
    Therapeutic Potential and Mechanistic Pathways of Plant-Based Supplements and Exercise Training in Blood Pressure Management: An Evidence-Based Review and Research Agenda
    Taati B, Badicu G, Vveinhardt J · Nutrients · 2026
  24. 24
    Diselenide-bridged dual-action nanoscavengers drive fasting-boosted BBB penetration and ROS-responsive resveratrol delivery for synergistic ischemic stroke therapy
    Chen Q, Zhang Q, Wang J et al. · J Nanobiotechnology · 2026
  25. 25
    Cardioprotective effect of resveratrol in myocardial ischemia/reperfusion injury and myocardial infarction: a pre-clinical meta-analysis in animal studies
    Wei SJ, Guo QH, Wei XY et al. · PeerJ · 2026

Metabolic health · 935

Open on PubMed
  1. 01
    Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis
    Gong D, Chen X, Dong Z et al. · Ren Fail · 2026
  2. 02
    Resveratrol and tomato pectin synergistically ameliorated metabolic disorder in high-fat-diet mice through the microbiota-gut-liver axis
    Zong X, Liu W, Wang R et al. · Food Res Int · 2026
  3. 03
    Dual-targeting strategies for cancer and diabetes: Converging pharmacological pathways and repurposed therapies
    Bhatti GK, Ahmed I, Sehrawat A et al. · Mol Aspects Med · 2026
  4. 04
    Chitosan-Based Thermosensitive Hydrogel Codelivering Berberine and Resveratrol Promotes Wound Healing of Bacterial Infection in Diabetic Mice
    Chen Z, Yan J, Wang Q et al. · ACS Appl Bio Mater · 2026
  5. 05
    Resveratrol alleviated diabetic retinal neuronal ferroptosis induced by high glucose through inhibiting HIF-1α and HMOX1 pathway
    Ye M, Jiang Y, Gong H et al. · Exp Eye Res · 2026
  6. 06
    Computational profiling of toxic mixtures associated with type 2 diabetes mellitus development: identification of key protective agents
    Baralić K, Jerotijević J, Pantelić M et al. · Food Chem Toxicol · 2026
  7. 07
    Bioactive Substances Characterization in Probiotic-Fermented Guava (Psidium guajava L.) Juice and Systematic Evaluation of its Anti-Hyperglycemic Activity
    Xu Y, Xiong T, Kang X et al. · Plant Foods Hum Nutr · 2026
  8. 08
    Beyond glycemic control: molecular mechanisms of metformin in modulating cytokine networks in polycystic ovary syndrome
    Ullah A, Chen Y, Zhang F et al. · Front Endocrinol (Lausanne) · 2026
  9. 09
    Modulation of the Gut Microbiota of Diabetes-Induced Mice Through Curcumin-Enriched Dietary Fibers Intervention
    Butorac K, Banić M, Zucko J et al. · Mol Nutr Food Res · 2026
  10. 10
    Diet and Trained Immunity in Cardiovascular Diseases
    Riksen NP, de Mast Q · Arterioscler Thromb Vasc Biol · 2026
  11. 11
    A Tetrahedral DNA Framework-Based Mitochondrial Anchoring System Promotes Diabetic Wound Healing via Mitophagy and Mitostress Regulation
    Yao Y, Zhang T, Li Y et al. · ACS Appl Mater Interfaces · 2025
  12. 12
    Influence of Certain Natural Bioactive Compounds on Glycemic Control: A Narrative Review
    Pelczyńska M, Szymon S, Konieczny M et al. · Nutrients · 2025
  13. 13
    Effects of Resveratrol on Browning and Insulin Signaling in Primary Murine Adipocytes: Modulation by Sex and Diabetic Status
    Xu X, Wu H, Chen J et al. · Nutrients · 2025
  14. 14
    Resveratrol mitigates diabetes-induced cardiac dysfunction via SIRT1/PPAR-α/PGC-1 pathway
    Fu R, Hao J · Mol Genet Genomics · 2025
  15. 15
    Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis
    Miao R, Zhang B, Zhou D et al. · Phytother Res · 2025SR
  16. 16
    Harnessing plant metabolic pathways for innovative diabetes management: unlocking the therapeutic potential of medicinal plants
    Okechukwu Paul-Chima U, Chinyere Nkemjika A, Melvin Nnaemeka U et al. · Plant Signal Behav · 2025
  17. 17
    Herbal Approaches to Diabetes Management: Pharmacological Mechanisms and Omics-Driven Discoveries
    Roy D, Ghosh M, Rangra NK · Phytother Res · 2025
  18. 18
    Bioactive Nutritional Components Within the Planetary Health Diet for Preventing Sarcopenic Obesity and Diabetic Sarcopenia: A Systematic Review
    Elvina L, Chen CM, Nguyen DHN et al. · Nutrients · 2025SR
  19. 19
    Resveratrol Analogs Ameliorate Mitochondrial Impairment and Insulin Resistance in a Streptozotocin-Induced In Vitro Model of Alzheimer's Disease
    Paszternák A, Varga K, Gyöngyössy R et al. · Int J Mol Sci · 2025
  20. 20
    Bioactive agarose-based hydrogels with granulated microstructures for accelerating diabetic wound healing
    Li S, Han J, Li B et al. · Int J Biol Macromol · 2025
  21. 21
    Dual-Targeting Nanoplatform to Regulate Metabolic Disorders: From Obesity to Obesity-Related Metabolic Dysfunction-Associated Steatotic Liver Disease
    Xiao Q, Wang C, Yang J et al. · Nano Lett · 2025
  22. 22
    A Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Impact of Resveratrol Supplementation on Anthropometric Indices in Patients With Type 2 Diabetes
    Lahouti M, Arzhang P, Azadbakht L · Phytother Res · 2025SR
  23. 23
    Resveratrol protection against cardiac remodeling and ischemia-reperfusion injury associated with hepatic lipid metabolism ameliorations and adipose tissue autotaxin pathway inhibition in a diet induced prediabetic female rat model
    Jouenne A, Sourdon J, Varlet I et al. · J Nutr Biochem · 2025
  24. 24
    Resveratrol restores insulin signaling and balances mitochondrial biogenesis and autophagy in streptozotocin-induced neurodegeneration in vitro
    Varga K, Sikur N, Paszternák A et al. · Eur J Pharm Sci · 2025
  25. 25
    Resveratrol ameliorates streptozotocin induced renal inflammation and promotes autophagy by mediating the SphK1 pathway via Sirt1 in Wistar rats
    Feng F, Li S, Shi J et al. · Food Chem Toxicol · 2025