SleepModerate evidence
Glycine
Amino acid with effects on sleep quality, core body temperature, and methylation. Inexpensive and well studied.
How it works
Glycine is an amino acid and also an inhibitory neurotransmitter that slightly lowers core body temperature, easing sleep onset. It is also a building block of collagen and of the body's antioxidant glutathione. Taken before bed, it improves subjective sleep quality in studies.
Goals
SleepLongevity (broad)
Timing
Evening
Price tier
Low
Dosage
3 g before bed, dissolved in water.
Considerations
Slightly sweet taste. Combination with NAC for glutathione synthesis is discussed.
Form
PowderCapsule
Scientific detail
NMDA modulationMethylationGlutathione synthesis
Proteostasis loss
Evidence base
