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Studien zu Alpha-Liponsäure (ALA)

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7.186 Studien insgesamt·Stand: 4. Juni 2026Auf PubMed öffnen

Stoffwechsel · 616

Auf PubMed öffnen
  1. 01
    Alpha-lipoic acid preserves uterine and ovarian integrity in streptozotocin-induced diabetic rats via modulation of TGF-β and HSP70 pathways
    Aksu E, Erbas O · Gynecol Endocrinol · 2026
  2. 02
    A single-component photocurable chitosan hydrogel mitigates inflammation and promotes angiogenesis and neurogenesis for diabetic wound healing
    Liu K, Zhang D, Liu C et al. · Biomaterials · 2026
  3. 03
    A coenzyme-based "interface-welding" hydrogel coating for titanium implants promotes diabetic osseointegration by regulating mitochondrial dynamics
    Duan Q, Geng W, He T et al. · Biomaterials · 2026
  4. 04
    Engineered neuro-vascular coupling and immunomodulation accelerates diabetic wound healing with a NO/O(2)-releasing cascade nanozyme hydrogel
    He CY, Wu Y, Gan TJ et al. · J Control Release · 2026
  5. 05
    Unveiling the Demographics and Clinical Characteristics of Diabetic Neuropathy: Findings From the National Health Insurance Service, 2012-2017
    Jeong SJ, Kim SK, Kim CH · J Diabetes · 2026
  6. 06
    Effect of ALA on preventing diabetic peripheral neuropathy in rats through mitochondrial axonal transport
    Tian J, An J, Song L et al. · PLoS One · 2026
  7. 07
    Bioactive Substances Characterization in Probiotic-Fermented Guava (Psidium guajava L.) Juice and Systematic Evaluation of its Anti-Hyperglycemic Activity
    Xu Y, Xiong T, Kang X et al. · Plant Foods Hum Nutr · 2026
  8. 08
    Effects of alpha-lipoic acid supplementation on cardiometabolic risk factors: A systematic review and dose-response meta-analysis
    Mohammadi S, Ashtary-Larky D, Alaghemand N et al. · Nutr Metab Cardiovasc Dis · 2026SR
  9. 09
    Immunological mechanisms and therapeutic advances in diabetic neuropathy
    Jiang S, Zhang L, Zhao L et al. · J Neurol · 2026
  10. 10
    Impact of Alpha Lipoic Acid as an Adjuvant Therapy on Inflammation and Fibrosis in Type 2 Diabetic Patients with Ischemic Cardiomyopathy: A Randomized Controlled Trial
    Shama AM, El-Bassiouny NA, Bahnacy YE et al. · J Diet Suppl · 2026RCT
  11. 11
    Carvacrol alleviates diabetic cardiomyopathy in rats: Targeting Cuproptosis pathway
    Attia H, Alshanwani A, Alatrouzi N et al. · Toxicol Appl Pharmacol · 2026
  12. 12
    The role of oral alpha-lipoic acid as an adjuvant antioxidant therapy in diabetic nephropathy among children and adolescents with type 1 diabetes: a randomized controlled trial
    Elhenawy YI, Thabet RA, Hegazy MGA et al. · J Diabetes Complications · 2026RCT
  13. 13
    A poly(lipoic acid)-based elastomer adhesive with synergistic activity of microenvironment regulation and peripheral neuropathy repair facilitates infectious diabetic wound healing
    Song H, Fu F, Chen Y et al. · Biomaterials · 2026
  14. 14
    Mitochondria-targeting compounds for management of metabolic and hemostatic abnormalities associated with heart dysfunctions in experimental type 2 diabetes
    Kuchmerovska T, Yanitska L, Horkunenko O et al. · Endocr Regul · 2025
  15. 15
    The Association of Lipoic Acid Synthase (LIAS) Gene Methylation With Diabetic Kidney Disease
    Feng Z, Liu T, Gao P et al. · J Diabetes Res · 2025
  16. 16
    Alterations of the ocular surface during diabetes: molecular mechanisms and therapeutic strategies
    Quintana-Pérez JC, Tamay-Cach F, Guillen-Castro SA et al. · Int Ophthalmol · 2025
  17. 17
    Hirata Syndrome Clinical Presentation and Management: A Single-Centre Experience
    Mudagall G, Saikia UK, Bhuyan AK et al. · J ASEAN Fed Endocr Soc · 2025
  18. 18
    Oral lipoteichoic and lipoic acids improve insulin resistance and body composition in porphyria mice on a high-carbohydrate diet
    Longo M, Rubio T, Lamelas A et al. · J Physiol Biochem · 2025
  19. 19
    Alleviating effects of polyphenol extract from rapeseed meal on type 2 diabetes in mice via modulation of gut microbiota and AMPK/mTOR signaling pathways
    Xia X, Zhang Z, Xu Z et al. · Food Res Int · 2025
  20. 20
    Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan
    Wimer LA, Kaneshiro KR, Ramirez J et al. · Cell Rep · 2025
  21. 21
    ROS/Glucose-Dissociable EGCG-Coated Oxygen-Supplying Nanocomposite Hydrogel for Diabetic Wound Therapy
    Sun S, Zhu R, Du J et al. · Int J Nanomedicine · 2025
  22. 22
    Effects of α-Lipoic Acid, vitamin E, and Selenium Combination on Inflammation-Independent ROS-Induced Damage in Kidney Tissue of Diabetic Mice
    Karatug Kacar A, Ertik O, Dinckurt N et al. · J Food Sci · 2025
  23. 23
    Impacts of Metabolic Reprogramming on the Onset of Diabetic Nephropathy in Mice With Varying Lias Gene Expression Levels
    Li S, Zhou J, Wallace ED et al. · Diabetes · 2025
  24. 24
    New Perspectives on Nutraceutical Insulin Sensitizing Agents in the Treatment of Psoriasis and Other Dermatological Diseases
    Morrone P, Caroppo F, De Pedrini A et al. · Int J Mol Sci · 2025
  25. 25
    Advances in α-Lipoic Acid for Disease Prevention: Mechanisms and Therapeutic Insights
    Wang Y, Jiang S, He Y et al. · Molecules · 2025

Energie & Ausdauer · 907

Auf PubMed öffnen
  1. 01
    Self-assembly of glycyrrhizic acid and aconitine alleviates heart failure by inhibiting autophagy and inducing reprogramming of energy metabolism
    Liu Y, Pu Z, Chen X et al. · Phytomedicine · 2026
  2. 02
    Identification and Validation of DLD as a Cuproptosis-Associated Biomarker in Preeclampsia
    Zheng S, Chen X, Tang W et al. · FASEB J · 2026
  3. 03
    Progress in the Research of Cuproptosis and Possible Targets for Gynecological Cancers
    Tian Y, Zhang S, Liu W · J Biochem Mol Toxicol · 2026
  4. 04
    Metabolic shifts, a consequence of hyperosmolarity, are a hallmark of mental disorders
    Schwartz L, Bakkar A, Bouillaud F et al. · J Psychiatr Res · 2026
  5. 05
    Dual-functional copper nanoplatform potentiates cuproptosis through p53 reactivation and metabolic reprogramming
    Ma L, Zheng H, Xie W et al. · J Colloid Interface Sci · 2026
  6. 06
    Citric Acid Cycle Genes and Nutrigenetics
    Vesnina A, Kozlova O, Ivanova S et al. · Int J Mol Sci · 2026
  7. 07
    Poly(Citric Acid) Bidirectional Regulator: Coordinating Iron Homeostasis to Suppress Stress Responses and Boosting Mitochondrial Bioenergetics for Enhanced Nerve Repair
    Liang X, Song Y, Dong X et al. · Adv Mater · 2026
  8. 08
    α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis
    Dong K, Zhang M, Xu J et al. · Nutrients · 2026
  9. 09
    Mechanically adaptive injectable hydrogels with dual-role oxidized cyclodextrin for pH-responsive drug delivery in chronic infected wound healing
    Wang Y, Jin L, Huang C et al. · Carbohydr Polym · 2026
  10. 10
    Redox-Responsive Self-Assembled Amphiphilic Nanosheets from Polyglycerol Sulfate-Lipoic Acid Copolymers for Targeted Cancer Drug Delivery
    Page TM, Ludwig K, Haider MS et al. · Biomacromolecules · 2026
  11. 11
    Alfa-Lipoic Acid and Lipoamide Can Promote Extracellular Coenzyme Q(10) Reduction in Presence of Hep G2 Cells; Involvement of Cell-Mediating α-Lipoic Acid- or Lipoamide-Coenzyme Q(10) Reduction Cycle
    Takahashi T, Okamoto T · J Nutr Sci Vitaminol (Tokyo) · 2026
  12. 12
    Lipoic Acid Ameliorates Lipopolysaccharide-Induced Inflammation via Inhibition of Glycolysis in RAW264.7 Macrophages
    Yue L, Wang K, Wang R et al. · Immun Inflamm Dis · 2026
  13. 13
    LIAS Promotes Cuproptosis in Prostate Cancer Cells by Suppressing Glycolysis via the p53 Signaling Pathway
    Tang Z, Guo P, Liu Y · Prostate · 2026
  14. 14
    LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer
    Wu Y, Zhang W, Jiang S et al. · Int J Mol Sci · 2025
  15. 15
    Α-Lipoic acid attenuates silica-induced pulmonary fibrosis through maintenance of iron homeostasis and improving mitochondrial function in airway epithelial cells
    Xu G, Yang X, Zhan B et al. · Int Immunopharmacol · 2025
  16. 16
    Alpha-Lipoic Acid in Early-Stage Alcohol-Related Brain Damage in Rats: A Comparative Pilot Study
    Staykov H, Dragomanova S, Hodzhev Y et al. · Molecules · 2025
  17. 17
    Pyruvate dehydrogenase complex component B: A Gene Associated with Cuproptosis and Encoding the Beta Subunit of Pyruvate Dehydrogenase Is Involved in the Oxidative Decarboxylation Reaction
    Liu R, Tang F, Zhang X et al. · DNA Cell Biol · 2025
  18. 18
    Impacts of Metabolic Reprogramming on the Onset of Diabetic Nephropathy in Mice With Varying Lias Gene Expression Levels
    Li S, Zhou J, Wallace ED et al. · Diabetes · 2025
  19. 19
    Lipoic Acid Based Redox-Responsive Degradable Antimicrobial Polymers
    Giri A, Aquib M, Choudhury A et al. · Macromol Rapid Commun · 2025
  20. 20
    Oxidation-responsive PEG-poly(α-lipoic acid) nanoparticles for coenzyme Q(10) delivery attenuate hepatic ischemia-reperfusion injury via ROS scavenging and ferroptosis inhibition
    Guan Y, Liu J, Yang J et al. · J Mater Chem B · 2025
  21. 21
    Cu(OH)(2) nanopesticide induced liver dysfunction in mice by targeting lipoylated tricarboxylic acid cycle proteins via ferredoxin 1
    Ren Z, Ren M, Ling W et al. · J Hazard Mater · 2025
  22. 22
    Self-assembled Cationic Poly (Thioctic acid)/Flavin-based Catalysts for Biomimetic Baeyer-Villiger Oxidation
    Lv Y, Zhang B, Xie Y et al. · Macromol Rapid Commun · 2025
  23. 23
    l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduction in Blood Lactate Concentration
    de Rozas A, Pérez-Díaz JJ, Muros JJ et al. · Nutrients · 2025RCT
  24. 24
    Inactivation of mitochondrial pyruvate dehydrogenase by singlet oxygen involves lipoic acid oxidation, side-chain modification and structural changes
    Gao Q, Hägglund P, Gamon LF et al. · Free Radic Biol Med · 2025
  25. 25
    Tumor-targeting and redox-responsive photo-cross-linked nanogel derived from multifunctional hyaluronic acid-lipoic acid conjugates for enhanced in vivo protein delivery
    Sun W, Jang MS, Zhan S et al. · Int J Biol Macromol · 2025

Longevity & Aging · 183

Auf PubMed öffnen
  1. 01
    Senomorphic Small Extracellular Vesicles Delivered by a Tissue-Adhesive α-Lipoic-Acid Hydrogel Enable Immuno-Rejuvenation for Bone-Tendon Interface Regeneration
    Kong L, Song W, Liu W et al. · Adv Sci (Weinh) · 2026
  2. 02
    SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways
    Weiss B, Miranda DR, Arrazati D et al. · Drug Des Devel Ther · 2026
  3. 03
    Intravenous longevity therapy: a critical review of evidence, mechanisms, and clinical utility
    Godic A, Townsend J · Acta Dermatovenerol Alp Pannonica Adriat · 2026
  4. 04
    α-Lipoic acid mitigates age-related cognitive decline by modulating PPARγ/NF-κB-mediated neuroinflammation
    Zhang Z, Zhang C, Zhao Y et al. · Exp Gerontol · 2026
  5. 05
    Age and mating status modulate combined efficacy of α-lipoic acid and climbing to mitigate high-fat diet-induced oxidative stress in Drosophila melanogaster
    Bheemaiah MM, Chattopadhyay D · Exp Gerontol · 2026
  6. 06
    Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan
    Wimer LA, Kaneshiro KR, Ramirez J et al. · Cell Rep · 2025
  7. 07
    Mesaconic acid as a key metabolite with anti-inflammatory and anti-aging properties produced by Lactobacillus plantarum 124 from centenarian gut microbiota
    Wu L, He H, Liang T et al. · NPJ Biofilms Microbiomes · 2025
  8. 08
    Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging
    Zhang Z, Wan Q, Zhu Y et al. · Nat Commun · 2025
  9. 09
    α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence
    Wang Y, Zheng Y, Liang X et al. · Sci Rep · 2025
  10. 10
    Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging
    Gupta S, Afzal M, Agrawal N et al. · Biogerontology · 2025
  11. 11
    Alpha-lipoic Acid: An Antioxidant with Anti-aging Properties for Disease Therapy
    Shanaida M, Lysiuk R, Mykhailenko O et al. · Curr Med Chem · 2025
  12. 12
    Influence of α-lipoic acid on longevity and stress resistance in Drosophila melanogaster fed with a high-fat diet
    Chattopadhyay D, Philip SM, Prabhakar G et al. · Biogerontology · 2024
  13. 13
    Effect of compound treatments on mouse lens viscoelasticity
    Maceo Heilman B, Mote K, Batchelor W et al. · Exp Eye Res · 2024
  14. 14
    Outcomes of dietary alpha-lipoic acid on testicular vascularization, steroid hormones, and seminal quality in aged Baladi bucks
    Abdelnaby EA, Fathi M, Salem NY et al. · BMC Vet Res · 2024
  15. 15
    Combating Atherosclerosis with Chirality/Phase Dual-Engineered Nanozyme Featuring Microenvironment-Programmed Senolytic and Senomorphic Actions
    Ding C, Min J, Tan Y et al. · Adv Mater · 2024
  16. 16
    Enhancing healthy aging with small molecules: A mitochondrial perspective
    Qin X, Li H, Zhao H et al. · Med Res Rev · 2024
  17. 17
    Ceria Nanoparticle Systems Alleviate Degenerative Changes in Mouse Postovulatory Aging Oocytes by Reducing Oxidative Stress and Improving Mitochondrial Functions
    Zhang D, Ji L, Yang Y et al. · ACS Nano · 2024
  18. 18
    (+)-Lipoic acid reduces mitochondrial unfolded protein response and attenuates oxidative stress and aging in an in vitro model of non-alcoholic fatty liver disease
    Longhitano L, Distefano A, Musso N et al. · J Transl Med · 2024
  19. 19
    Toxicology of pharmaceutical and nutritional longevity compounds
    Kahraman C, Kaya Bilecenoglu D, Sabuncuoglu S et al. · Expert Rev Mol Med · 2023
  20. 20
    Modulation of Cellular Senescence in HEK293 and HepG2 Cells by Ultrafiltrates UPla and ULu Is Partly Mediated by Modulation of Mitochondrial Homeostasis under Oxidative Stress
    Zhou J, Liu K, Bauer C et al. · Int J Mol Sci · 2023
  21. 21
    Reflections of an Aging Free Radical Part 2: Meeting Inspirational People
    Halliwell B · Antioxid Redox Signal · 2023
  22. 22
    Pharmacological Treatments for Presbyopia
    Orman B, Benozzi G · Drugs Aging · 2023
  23. 23
    Effects of alpha-lipoic acid on ram semen cryopreservation and post-thaw life span
    Onder NT, Alcay S, Nur Z · Andrologia · 2022
  24. 24
    In Silico Analysis to Link Insulin Resistance, Obesity and Ageing with Alzheimer's Disease
    Sarkar P, Jayaraj P, Patwardhan K et al. · J Mol Neurosci · 2021
  25. 25
    Dihydrolipoic acid-coated gold nanocluster bioactivity against senescence and inflammation through the mitochondria-mediated JNK/AP-1 pathway
    Wang HH, Lin CJ, Tseng YM et al. · Nanomedicine · 2021