Studienlage

Studien zu Ca-AKG (Calcium-Alpha-Ketoglutarat)

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12.000 Studien insgesamt·Stand: 5. Juni 2026Auf PubMed öffnen

Longevity & Aging · 135

Auf PubMed öffnen
  1. 01
    α-KG alleviates mitochondrial dysfunction and attenuates HPDLSCs senescence in periodontitis through LKB1-AMPK activation
    Zhang X, Li L, Liu H et al. · Cell Signal · 2026
  2. 02
    Insights into the therapeutic strategies for aging and aging-associated diseases
    Dong R, Wu Q, Kan J et al. · Signal Transduct Target Ther · 2026
  3. 03
    Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals
    Pabis K, Wang W, Selvarajoo K et al. · Aging Cell · 2026
  4. 04
    Epigenetic remodeling induced by fatty acids: Chromatin modifications and cellular senescence during lipid overload
    Ávila-Galicia KE, Alarcón-Aguilar A, Soto-Reyes E et al. · Ageing Res Rev · 2026
  5. 05
    The novel synbiotic (Lacticaseibacillus rhamnosus NKU FL1-11 and galacto-oligosaccharides) alleviates HCA IQ-triggered aging by reprogramming gut microbial metabolism to coordinate the enterohepatic β-glucuronidase activity
    Li D, Gao X, Liu W et al. · Food Res Int · 2026
  6. 06
    Host immunosenescence compromises Mycobacterium tuberculosis clearance
    Pahwa F, Chaudhary S, Gupta A et al. · Aging (Albany NY) · 2026
  7. 07
    Aging-Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment
    Udumula MP, Km A, Rashid F et al. · Aging Cell · 2026
  8. 08
    Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism
    Shirazi S, Esawi E, Nassar ZD et al. · J Cell Biochem · 2026
  9. 09
    Early-life NAD(+) deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood
    Karim M, Yaku K, Kim JD et al. · Cell Rep · 2026
  10. 10
    "Metabolic memory" of aging: anchoring, transmission, and frontiers of transgenerational intervention
    Zhao Y · Biogerontology · 2026
  11. 11
    A metabolic atlas of mouse aging
    Pilley SE, Awad D, Latumalea D et al. · Cell Metab · 2026
  12. 12
    Macrophage Trem2 deficiency aggravates aging-induced vascular remodeling by acting as a non-classical receptor of interleukin-13
    Chen Y, Zeng Z, Wei Z et al. · Mol Biomed · 2025
  13. 13
    Fiber scaffolds augment aged bone regeneration by modulating energy metabolism, immunity and angiogenesis
    Liu H, Wei J, Liu J et al. · J Control Release · 2025
  14. 14
    The m6A modification-mediated upregulation of ETS2 translation drives arsenic-induced spermatogonial senescence
    Zhang XY, Zhang YH, Liang NN et al. · Free Radic Biol Med · 2025
  15. 15
    α-Ketoglutarate Ameliorates Sarcopenia in D-Galactose-Induced Aging Mice by Modulating Protein Homeostasis and Optimizing Mitochondrial Function
    Zhang Y, Wang H, Zhang Y et al. · Nutrients · 2025
  16. 16
    Recruitment evaluation of a gerotherapeutic randomized controlled trial testing alpha-ketoglutarate in biologically older, middle-aged adults (ABLE)
    Lim ZM, Chew YE, Guan L et al. · Exp Gerontol · 2025RCT
  17. 17
    Identifying the target, mechanism, and agonist of α-ketoglutaric acid in delaying mesenchymal stem cell senescence
    Cui Z, Li J, Li C et al. · Cell Rep · 2025
  18. 18
    R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity
    Couteau F, Gagné LM, Boulay K et al. · Nucleic Acids Res · 2025
  19. 19
    Hypoxia increases methylated histones to prevent histone clipping and heterochromatin redistribution during Raf-induced senescence
    Chang S, Moon R, Nam D et al. · Nucleic Acids Res · 2025
  20. 20
    Effect of Dietary Ketosis and Nicotinamide Riboside on Hippocampal Krebs Cycle Intermediates and Mitochondrial Energetics in a DNA Repair-Deficient 3xTg/POLβ(+/-) Alzheimer Disease Mouse Model
    Pawlosky R, Demarest TG, King MT et al. · J Neurochem · 2025
  21. 21
    PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1
    Yin M, Weng Y, Qi T · Mol Med Rep · 2025
  22. 22
    DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice
    Huang G, Li Z, Liu X et al. · Nat Neurosci · 2024
  23. 23
    Alpha-ketoglutarate ameliorates age-related and surgery induced temporomandibular joint osteoarthritis via regulating IKK/NF-κB signaling
    Ye X, Li X, Qiu J et al. · Aging Cell · 2024
  24. 24
    Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin
    Miller RA, Harrison DE, Cortopassi GA et al. · Geroscience · 2024
  25. 25
    Anti-aging effects of medicinal plants and their rapid screening using the nematode Caenorhabditis elegans
    Chen X, Bahramimehr F, Shahhamzehei N et al. · Phytomedicine · 2024

Stoffwechsel · 210

Auf PubMed öffnen
  1. 01
    Salecan improves diet-induced obesity and hepatic steatosis by regulating citrate cycle intermediates
    Liu K, Chen S, Cao M et al. · Int J Biol Macromol · 2026
  2. 02
    Metabolomic and lipidomic plasma profiles according to metabolic dysfunction-associated steatotic liver diseases (MASLD) stages in the absence of type 2 diabetes (T2D)
    Pradeau M, Coll JC, Berteaux A et al. · Metabolomics · 2026
  3. 03
    Integrated network pharmacology and multi-omics reveals GLUD1-mediated α-KG/Glu conversion in regulating amino acid metabolism: a mechanism of Dangua Fang against type 2 diabetes mellitus
    Han Z, Yang L, Wang Z et al. · J Ethnopharmacol · 2026
  4. 04
    Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism
    Shirazi S, Esawi E, Nassar ZD et al. · J Cell Biochem · 2026
  5. 05
    Mitochondria as Epigenetic Regulators of β-Cell Identity and Plasticity: A Metabolo-Epigenetic Perspective
    Kim Y · Cells · 2026
  6. 06
    Metabolic small molecules materialized hydrogel promotes diabetic bone regeneration through osteoimmunological remodeling
    Li Q, Xu K, Li J et al. · Biomaterials · 2026
  7. 07
    Fenitrothion exposure induces hyperglycemia in juvenile rats: Impeded glycolysis and promoted gluconeogenesis mediated by acetyl-CoA and oxaloacetate metabolism dysregulation
    Guo Y, Gu D, Okeke ES et al. · J Hazard Mater · 2026
  8. 08
    Alpha-ketoglutarate supplementation improves hyperglycemia and attenuates the decrease in GLUT4 and PGC-1α proteins in adipose tissue of streptozotocin-high-fat diet-induced diabetic mice
    Takemura A, Matsunaga Y, Hajime S et al. · J Nutr Sci · 2025
  9. 09
    Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
    Jenkins BJ, Jenkins YR, Ponce-Garcia FM et al. · Nat Commun · 2025
  10. 10
    Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia
    Sun JK, Hart RP, Herrup K et al. · Nat Commun · 2025
  11. 11
    The Relationship Between Insulin Resistance and Cancer in Humans
    Adeva-Andany MM, Adeva-Contreras L, Ameneiros-Rodriguez E et al. · Horm Metab Res · 2025
  12. 12
    Metabolomic Signatures of Transitional Breast Milk in Gestational Diabetes Mellitus: A Case-Control Study Assessing the Impact of Insulin Therapy
    Küçükoğlu Keser M, Yalçin SS, Reçber T et al. · Nutrients · 2025
  13. 13
    Tissue-specific differences impacts therapeutic outcomes of mitochondrial transplantation through regulation of bioenergetics in metabolic syndrome
    Pareek J, Mudgal P, Sindhu N et al. · Cell Tissue Res · 2025
  14. 14
    BCAT1 Activation Reprograms Branched-Chain Amino Acid Metabolism and Epigenetically Promotes Inflammation in Diabetic Retinopathy
    Wang J, Yin Z, Yang J et al. · Invest Ophthalmol Vis Sci · 2025
  15. 15
    Endogenous dysregulated energy and amino acid metabolism delay scaffold-guided large volume bone regeneration in a diabetic rat model with Leptin receptor deficiency
    Dias DB, Chan W, Ellinghaus A et al. · Acta Biomater · 2025
  16. 16
    Targeted Delivery of α-ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes
    Wang J, Cao J, Zhang S et al. · Adv Sci (Weinh) · 2025
  17. 17
    Variations in Human Milk Metabolites After Gestational Diabetes: Associations with Infant Growth
    Fradet A, Berthiaume L, Laroche LA et al. · Nutrients · 2025
  18. 18
    Therapeutic Potential of FTO Demethylase in Metabolism and Disease Pathways
    Somala CS, Sathyapriya S, Bharathkumar N et al. · Protein J · 2025
  19. 19
    Urine Tricarboxylic Acid Cycle Metabolites and Risk of End-stage Kidney Disease in Patients With Type 2 Diabetes
    Liu JJ, Liu S, Zheng H et al. · J Clin Endocrinol Metab · 2025
  20. 20
    Analysis of metabolites associated with ADIPOQ genotypes in individuals with type 2 diabetes mellitus
    Diniz TG, de Assis CS, de Sousa BRV et al. · Sci Rep · 2024
  21. 21
    Fucoidan prevents diabetic cognitive dysfunction via promoting TET2-mediated active DNA demethylation in high-fat diet induced diabetic mice
    Chen L, Li Y, Zhang X et al. · Int J Biol Macromol · 2024
  22. 22
    Excessive palmitic acid disturbs macrophage α-ketoglutarate/succinate metabolism and causes adipose tissue insulin resistance associated with gestational diabetes mellitus
    Zhao X, Zhang W, Jiang F et al. · Free Radic Biol Med · 2024
  23. 23
    Sucrose-induced metabolic syndrome differentially affects energy metabolism and fiber phenotype of EDL and soleus muscles during exercise in the rat
    Eduardo RC, Karla C · Physiol Rep · 2024
  24. 24
    Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i
    Harada M, Adam J, Covic M et al. · Cardiovasc Diabetol · 2024
  25. 25
    Deleting the ribosomal prolyl hydroxylase OGFOD1 protects mice against diet-induced obesity and insulin resistance
    Rodriguez R, Harris M, Kennedy LM · PLoS One · 2024