Ca-AKG (Calcium Alpha-Ketoglutarate)
A central metabolite of the citric-acid cycle whose levels fall with age. In mice it extended healthspan and reduced frailty — in humans the evidence is still young.
How it works
Alpha-ketoglutarate is a central molecule in the citric-acid cycle (energy production) and a cofactor for enzymes that demethylate DNA and histones, i.e. epigenetic switches. AKG levels fall with age. In animal models Ca-AKG extended healthy lifespan; solid human data are still limited.
Dosage
In the longevity scene usually 1,000–2,000 mg/day (calcium salt). Patience required — effects, if any, are slow and tracked via biomarkers.
Considerations
The animal data are intriguing: in old mice Ca-AKG extended healthspan and reduced frailty (Shahmirzadi 2020). In humans there are only small, uncontrolled studies so far (e.g. on epigenetic age) — promising, but not proven. AKG is an endogenous metabolite with good tolerability; classify it as a 'longevity bet', not an established benefit. Bryan Johnson includes it in his Blueprint stack.
