Alpha-Lipoic Acid (ALA)
A mitochondrial coenzyme and 'universal antioxidant' that works in both water- and fat-soluble environments. Best supported for blood sugar and diabetic neuropathy.
How it works
Alpha-lipoic acid is a coenzyme in mitochondrial energy metabolism and an antioxidant active in both water- and fat-soluble compartments. It scavenges free radicals and regenerates other antioxidants such as vitamin C, E and glutathione. Its best-supported clinical role is in diabetic neuropathy and improving insulin sensitivity.
Dosage
Typically 300–600 mg/day, on an empty stomach (food lowers absorption). The R-form is more bioavailable than the racemic R/S mixture.
Considerations
Strongest evidence in diabetic neuropathy (often intravenous in studies) and for improving insulin sensitivity. As a broad 'anti-aging' agent the human evidence is thinner. Caution: ALA can lower blood sugar — use under medical guidance with diabetes medication. Take on an empty stomach.
