OtherEmerging
Spermidine (from wheat germ)
Polyamine with autophagy-inducing effects in vivo. Early-phase human data on cognition and mortality in cohorts.
How it works
Spermidine is a polyamine (e.g. in wheat germ) that triggers the cell's waste-disposal process, autophagy, i.e. the recycling of damaged cell components. It thus partly mimics the effects of fasting. Observational studies link a spermidine-rich diet to lower mortality; intervention data are still early.
Goals
Longevity (broad)Cognition
Timing
Morning
Price tier
Premium
Dosage
1–6 mg/day, morning. Wheat germ extracts are the standard.
Considerations
Also found in food (cheese, legumes, mushrooms). Supplementation only useful with low dietary intake.
Form
Capsule
Scientific detail
Autophagy inductioneIF5A hypusination
Disabled macroautophagyMitochondrial dysfunction
Evidence base
Studies on Spermidine (from wheat germ)
My pick
Currently in my stack:
Spermidin aus Bio-Weizenkeim — Ballaststoffe & Protein
Currently testing — wheat-germ spermidine to support autophagy.
