Topic cluster

NAD+ / Sirtuins

How NAD+ powers cellular energy and DNA repair — and how sirtuins ride on top of it as epigenetic guardians. NMN, resveratrol, and everything that feeds the system.

4 articles · 4 compounds in the database
Subtopics
NMN (3)NAD⁺ (2)Sirtuins (2)Age reversal (1)Sinclair (1)
Articles
Flat-lay of the Blueprint stack — creatine, omega-3, collagen, NMN/NR, Ca-AKG, curcumin, microbiome prebiotics on a dark background
Longevity Protocols

Bryan Johnson's Blueprint: What the Million-Dollar Longevity Stack Actually Delivers

Nils GregersenNils GregersenFounder & author · Longevity enthusiast
5 min
A fit man in his early 60s in a bright kitchen behind a curated row of longevity supplements (D3+K2, magnesium, omega-3, creatine, CoQ10, green tea)
Supplements

Longevity Supplements: The Honest List — What's Proven and What's Overhyped

Nils GregersenNils GregersenFounder & author · Longevity enthusiast
3 min
Visualization of the biological clock — aging as a programmable process
Epigenetics & Age Reversal

Aging as a Curable Disease: Can We Reverse the Biological Clock?

Nils GregersenNils GregersenFounder & author · Longevity enthusiast
4 min
Cellular illustration of NAD+ and DNA repair
NAD+ / Sirtuins

NMN, NAD+ and Sirtuins: What the 2026 Research Actually Says

Nils GregersenNils GregersenFounder & author · Longevity enthusiast
5 min
Compounds & substances
NAD⁺ precursorEmerging

NMN (Nicotinamide Mononucleotide)

Direct NAD+ precursor. Early-phase clinical evidence shows raised blood NAD+ levels after oral dosing.

Dose250–500 mg/day, morning.
· Morning
NAD⁺ precursorEmerging

Nicotinamide Riboside (NR)

An NAD⁺ precursor and direct competitor to NMN. Both demonstrably raise NAD⁺ levels in humans — whether that translates into measurably healthier aging is still open.

DoseStudies mostly use 250–500 mg/day. The best-known branded form of NR is 'Niagen'.
· Any time
AntioxidantPreliminary

Resveratrol

The red-wine polyphenol that made sirtuin longevity research (David Sinclair) famous. Fascinating mechanisms — but disappointing human evidence and poor bioavailability. A textbook case of hype meeting reality.

DoseStudies mostly use 150–500 mg/day, with fat due to poor absorption. Often combined with NMN (the Sinclair protocol) — but the synergy is unproven in humans.
· With food
AntioxidantPreliminary

Pterostilbene

The 'better resveratrol' — a methylated stilbenoid (e.g. from blueberries) with markedly higher bioavailability. Often paired with NMN/NR, but still little studied in humans.

DoseStudies mostly use 50–125 mg/day. Frequently combined with NAD precursors (NMN/NR).
· With food